Metabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide Synthesis Pathways in INS-1 Cells

Increased Glucose Metabolism and Glycerolipid Formation by Fatty Acids and GPR40 Receptor Signaling Underlies the Fatty Acid Potentiation of Insulin Secretion

(2014) Mahmoud El-Azzouny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression effects of AICAR on insulin secretion involved in peroxisome proliferator-activated receptor gamma changes in INS-1 cells

(2014) H. Guo et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Dehydroepiandrosterone-sulfate (DHEAS) promotes MIN6 cells insulin secretion via inhibition of AMP-activated protein kinase

(2013) Jiang Yue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

Metabolome Response to Glucose in the β-Cell Line INS-1 832/13

(2013) Matthew A. Lorenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of AMPK Catabolic Action by GSK3

(2013) Tsukasa Suzuki et al.   MOLECULAR CELL

XCMS Online: A Web-Based Platform to Process Untargeted Metabolomic Data

(2012) Ralf Tautenhahn et al.   ANALYTICAL CHEMISTRY

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

(2012) D. Grahame Hardie et al.   CHEMISTRY & BIOLOGY

AMPK Enhances Insulin-Stimulated GLUT4 Regulation via Lowering Membrane Cholesterol

(2012) Kirk M. Habegger et al.   ENDOCRINOLOGY

Chromatographic behaviour of peptides following dimethylation with H2/D2-formaldehyde: Implications for comparative proteomics

(2012) Joseph M. Boutilier et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Charles F Burant et al.   LANCET

Role of AMPK in pancreatic beta cell function

(2012) Accalia Fu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation

(2012) Johanna T Lanner et al.   NATURE MEDICINE

AICAR inhibits ceramide biosynthesis in skeletal muscle

(2012) Katherine A Erickson et al.   Diabetology & Metabolic Syndrome

Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction

(2012) Ebru Boslem et al.   Islets

Monitoring metabolites consumption and secretion in cultured cells using ultra-performance liquid chromatography quadrupole–time of flight mass spectrometry (UPLC–Q–ToF-MS)

(2011) Giuseppe Paglia et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

(2011) D. Grahame Hardie   BIOCHEMICAL SOCIETY TRANSACTIONS

KEGG for integration and interpretation of large-scale molecular data sets

(2011) M. Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Quantitative and Wide-Ranging Profiling of Phospholipids in Human Plasma by Two-dimensional Liquid Chromatography/Mass Spectrometry

(2010) Yoshiaki Sato et al.   ANALYTICAL CHEMISTRY

AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells

(2010) A. F. Santidrian et al.   BLOOD

Protein Farnesylation-Dependent Raf/Extracellular Signal-Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic  -Cells

(2010) A. Kowluru et al.   DIABETES

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Adenosine Monophosphate-activated Protein Kinase Induces Cholesterol Efflux from Macrophage-derived Foam Cells and Alleviates Atherosclerosis in Apolipoprotein E-deficient Mice

(2010) Dan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intravenous AICAR During Hyperinsulinemia Induces Systemic Hemodynamic Changes but Has No Local Metabolic Effect

(2010) Marlies Bosselaar et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

(2009) Sarah A Scott et al.   Nature Chemical Biology

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

(2008) H. Boon et al.   DIABETOLOGIA