Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response

The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson’s disease

(2015) J. Schapansky et al.   NEUROSCIENCE

Both Th1 and Th17 Are Immunopathogenic but Differ in Other Key Biological Activities

(2014) C. A. Cox et al.   JOURNAL OF IMMUNOLOGY

LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

(2014) Isabella Russo et al.   Journal of Neuroinflammation

Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?

(2014) Georgina L Hold   WORLD JOURNAL OF GASTROENTEROLOGY

Innate and adaptive immunity in inflammatory bowel disease

(2013) Alessandra Geremia et al.   AUTOIMMUNITY REVIEWS

Uveitis in Mouse and Man

(2013) John V Forrester et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Differential Involvement of Th1 and Th17 in Pathogenic Autoimmune Processes Triggered by Different TLR Ligands

(2013) G. Shi et al.   JOURNAL OF IMMUNOLOGY

Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis

(2013) Daniel Ness et al.   PLoS One

An emerging role for LRRK2 in the immune system

(2012) Nicolas Dzamko et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

IL-17-producing γδ T cells and innate lymphoid cells

(2012) Caroline E. Sutton et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia

(2012) Beomsue Kim et al.   PLoS One

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

(2012) Nicolas Dzamko et al.   PLoS One

Meta-analysis of published studies identified eight additional common susceptibility loci for Crohnʼs disease and ulcerative colitis

(2011) Junji Umeno et al.   INFLAMMATORY BOWEL DISEASES

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

(2011) Mansoureh Hakimi et al.   JOURNAL OF NEURAL TRANSMISSION

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation

(2011) Jonathan Thévenet et al.   PLoS One

LRRK2 and Parkinson Disease

(2010) Justus C. Dächsel et al.   ARCHIVES OF NEUROLOGY

Interleukin-18 in Intestinal Inflammation: Friend and Foe?

(2010) Britta Siegmund   IMMUNITY

A look at autoimmunity and inflammation in the eye

(2010) Rachel R. Caspi   JOURNAL OF CLINICAL INVESTIGATION

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease

(2009) Arthur Kaser et al.   SEMINARS IN IMMUNOLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

(2008) Dror Luger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS