Potential Role of Notch Signalling in CD34+ Chronic Myeloid Leukaemia Cells: Cross-Talk between Notch and BCR-ABL

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells

(2014) F. Nakahara et al.   BLOOD

Notch signaling: switching an oncogene to a tumor suppressor

(2014) C. Lobry et al.   BLOOD

Targeting survival pathways in chronic myeloid leukaemia stem cells

(2013) A Sinclair et al.   BRITISH JOURNAL OF PHARMACOLOGY

The matricellular protein CCN3 regulates NOTCH1 signalling in chronic myeloid leukaemia

(2013) Sukanya Suresh et al.   JOURNAL OF PATHOLOGY

Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors

(2012) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

Preclinical Analysis of the  -Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia

(2012) J. B. Samon et al.   MOLECULAR CANCER THERAPEUTICS

Targeting Chronic Myeloid Leukemia Stem Cells

(2012) Ross Kinstrie et al.   Current Hematologic Malignancy Reports

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

(2011) Teresa Palomero et al.   CELL CYCLE

The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells

(2011) F Pellicano et al.   LEUKEMIA

Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling

(2011) E. Anders Kolb et al.   PEDIATRIC BLOOD & CANCER

Split ends in CML: divergent roles of Hes1

(2010) C. Jamieson   BLOOD

Notch protection against apoptosis in T-ALL cells mediated by GIMAP5

(2010) Nicholas Chadwick et al.   BLOOD CELLS MOLECULES AND DISEASES

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

(2010) Miguel Aste-Amézaga et al.   PLoS One

BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase C 

(2009) F. Pellicano et al.   BLOOD

Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia

(2009) F. Nakahara et al.   BLOOD

Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein  -Secretase for the Treatment of Alzheimer's Disease

(2009) R. L. Martone et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification of novel Notch target genes in T cell leukaemia

(2009) Nicholas Chadwick et al.   Molecular Cancer

Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells

(2009) Liyun Sang et al.   TRENDS IN MOLECULAR MEDICINE

In vitro validation of  -secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia

(2008) K. De Keersmaecker et al.   HAEMATOLOGICA

Early in vivo changes of the transcriptome in Philadelphia chromosome-positive CD34+ cells from patients with chronic myelogenous leukaemia following imatinib therapy

(2008) D Bruennert et al.   LEUKEMIA

Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia

(2008) C Graux et al.   LEUKEMIA

Notch signaling inhibits the growth of the human chronic myeloid leukemia cell line K562

(2008) Dan-Dan Yin et al.   LEUKEMIA RESEARCH

Notch and BCR signaling synergistically promote the proliferation of Raji B-lymphoma cells

(2008) Fei He et al.   LEUKEMIA RESEARCH

Rational targeting of Notch signaling in cancer

(2008) P Rizzo et al.   ONCOGENE

Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice

(2008) T Mizuno et al.   ONCOGENE