EIF4EBP1 Overexpression Is Associated with Poor Survival and Disease Progression in Patients with Hepatocellular Carcinoma

Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail

(2015) Weijia Cai et al.   Oncotarget

MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas

(2014) Michal Grzmil et al.   JOURNAL OF CLINICAL INVESTIGATION

eRF3b, a Biomarker for Hepatocellular Carcinoma, Influences Cell Cycle and Phosphoralation Status of 4E-BP1

(2014) Man Li et al.   PLoS One

eIF3a is over-expressed in urinary bladder cancer and influences its phenotype independent of translation initiation

(2014) Rita Spilka et al.   CELLULAR ONCOLOGY

Many roads from mTOR to eIF4F

(2013) Carson C. Thoreen   BIOCHEMICAL SOCIETY TRANSACTIONS

Eukaryotic translation initiation factor 4E (eIF4E) expression is associated with breast cancer tumor phenotype and predicts survival after anthracycline chemotherapy treatment

(2013) Tuomas Heikkinen et al.   BREAST CANCER RESEARCH AND TREATMENT

Eukaryotic translation initiation factors in cancer development and progression

(2013) Rita Spilka et al.   CANCER LETTERS

Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: Implications for the treatment of human liver cancer

(2013) Chunmei Wang et al.   CELL CYCLE

Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells

(2013) X Li et al.   Cell Death & Disease

Anti-oncogenic potential of the eIF4E-binding proteins

(2012) Y Martineau et al.   ONCOGENE

Overexpression of eIF3a in Squamous Cell Carcinoma of the Oral Cavity and Its Putative Relation to Chemotherapy Response

(2012) Rita Spilka et al.   Journal of Oncology

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1

(2011) Elin Karlsson et al.   GENES CHROMOSOMES & CANCER

Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer

(2011) Jae Hong No et al.   GYNECOLOGIC ONCOLOGY

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells

(2010) Qinjie Weng et al.   INVESTIGATIONAL NEW DRUGS

Cancer gene discovery in hepatocellular carcinoma

(2010) Lars Zender et al.   JOURNAL OF HEPATOLOGY

Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1

(2010) M. Aoyagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

(2008) Augusto Villanueva et al.   GASTROENTEROLOGY

Silibinin inhibits hypoxia-inducible factor-1α and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy

(2008) P García-Maceira et al.   ONCOGENE