Dysregulated Serum IL-23 and SIRT1 Activity in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis

Sirt1 activity in peripheral blood mononuclear cells from patients with rheumatoid arthritis

(2014) Daniel Wendling et al.   JOINT BONE SPINE

IL-23 Induces Receptor Activator of NF- B Ligand Expression on CD4+ T Cells and Promotes Osteoclastogenesis in an Autoimmune Arthritis Model

(2014) J. H. Ju et al.   JOURNAL OF IMMUNOLOGY

SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1

(2013) Weirong Wang et al.   APOPTOSIS

Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease

(2013) Céline Molle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetics and epigenetics of rheumatoid arthritis

(2013) Sebastien Viatte et al.   Nature Reviews Rheumatology

Emerging cell and cytokine targets in rheumatoid arthritis

(2013) Gerd R. Burmester et al.   Nature Reviews Rheumatology

Imbalance between HAT and HDAC Activities in the PBMCs of Patients with Ankylosing Spondylitis or Rheumatoid Arthritis and Influence of HDAC Inhibitors on TNF Alpha Production

(2013) Eric Toussirot et al.   PLoS One

Deficient spontaneous in vitro apoptosis and increased tmTNF reverse signaling-induced apoptosis of monocytes predict suboptimal therapeutic response of rheumatoid arthritis to TNF inhibition

(2013) Undine Meusch et al.   ARTHRITIS RESEARCH & THERAPY

CD56+ monocytes have a dysregulated cytokine response to lipopolysaccharide and accumulate in rheumatoid arthritis and immunosenescence

(2013) Marco Krasselt et al.   ARTHRITIS RESEARCH & THERAPY

Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis

(2013) Daniel Wendling et al.   Clinical Epigenetics

Sirtuin-1 is a nutrient-dependent modulator of inflammation

(2013) Maya E. Kotas et al.   Adipocyte

Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence

(2012) Jun Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

(2012) Odile Gabay et al.   ARTHRITIS AND RHEUMATISM

Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages

(2012) Cláudia A. Fernandes et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirtuin activators and inhibitors

(2012) José M. Villalba et al.   BIOFACTORS

Sirt1: Def-eating senescence?

(2012) Salvatore Fusco et al.   CELL CYCLE

Sirtuin 1 Is a Key Regulator of the Interleukin-12 p70/Interleukin-23 Balance in Human Dendritic Cells

(2012) Yolanda Alvarez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-23: A key cytokine in inflammatory diseases

(2011) Emilie Duvallet et al.   ANNALS OF MEDICINE

SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance

(2011) F. Niederer et al.   ANNALS OF THE RHEUMATIC DISEASES

Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

(2011) Mona Dvir-Ginzberg et al.   ARTHRITIS AND RHEUMATISM

Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis

(2011) Jelena Vojinovic et al.   ARTHRITIS AND RHEUMATISM

Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients

(2011) Justin Gillespie et al.   ARTHRITIS AND RHEUMATISM

Histone Deacetylase Inhibitors Impair Antibacterial Defenses of Macrophages

(2011) Matteo Mombelli et al.   JOURNAL OF INFECTIOUS DISEASES

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts

(2011) Xiaoxia Zhu et al.   PLoS One

SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway

(2010) Viktoria Gagarina et al.   ARTHRITIS AND RHEUMATISM

Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection

(2010) T. Roger et al.   BLOOD

Histone Deacetylase Inhibitors Suppress Inflammatory Activation of Rheumatoid Arthritis Patient Synovial Macrophages and Tissue

(2010) Aleksander M. Grabiec et al.   JOURNAL OF IMMUNOLOGY

Increased Interleukin 21 (IL-21) and IL-23 Are Associated with Increased Disease Activity and with Radiographic Status in Patients with Early Rheumatoid Arthritis

(2010) T. K. RASMUSSEN et al.   JOURNAL OF RHEUMATOLOGY

Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2A

(2010) J. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase inhibitors: a new and promising drug class for the treatment of arthritis?

(2010) Éric Toussirot et al.   Clinical Epigenetics

Histone deacetylases in viral infections

(2010) Georges Herbein et al.   Clinical Epigenetics

Aging-dependent upregulation of IL-23p19 gene expression in dendritic cells is associated with differential transcription factor binding and histone modifications

(2009) Rabab El Mezayen et al.   AGING CELL

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis

(2009) L. Melis et al.   ANNALS OF THE RHEUMATIC DISEASES

SIRT1 regulation of apoptosis of human chondrocytes

(2009) Koji Takayama et al.   ARTHRITIS AND RHEUMATISM

SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

(2009) Tong Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Silent information regulator, Sirtuin 1, and age-related diseases

(2009) Li Zeng et al.   Geriatrics & Gerontology International

Bcl-3-Regulated Transcription from Major Immediate-Early Promoter of Human Cytomegalovirus in Monocyte-Derived Macrophages

(2009) K. A. Khan et al.   JOURNAL OF IMMUNOLOGY

Monocyte Derived Interleukin (IL)-23 Is an Important Determinant of Synovial IL-17A Expression in Rheumatoid Arthritis

(2009) L. K. STAMP et al.   JOURNAL OF RHEUMATOLOGY

Anti-inflammatory mechanisms of resveratrol in activated HMC-1 cells: Pivotal roles of NF-κB and MAPK

(2009) Ok-Hwa Kang et al.   PHARMACOLOGICAL RESEARCH

Abundant expression of the interleukin (IL)23 subunit p19, but low levels of bioactive IL23 in the rheumatoid synovium: differential expression and Toll-like receptor-(TLR) dependent regulation of the IL23 subunits, p19 and p40, in rheumatoid arthritis

(2008) F Brentano et al.   ANNALS OF THE RHEUMATIC DISEASES

Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

(2008) D. M. Taylor et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Blocking TH 17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo

(2008) Daniela Bosisio et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epigenetic modifications in rheumatoid arthritis

(2008) Simon Strietholt et al.   ARTHRITIS RESEARCH & THERAPY

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

(2007) Antero Salminen et al.   AGEING RESEARCH REVIEWS