Article
Oncology
Rebekka Bitsch, Annina Kurzay, Feyza Oezbay Kurt, Carolina De la Torre, Samantha Lasser, Alisa Lepper, Alina Siebenmorgen, Verena Mueller, Peter Altevogt, Jochen Utikal, Viktor Umansky
Summary: STAT3 inhibitor Napabucasin can block the accumulation and activity of MDSC and improve the prognosis of patients with malignant melanoma. Patients with high expression of activated STAT3 in M-MDSC have shorter progression-free survival, indicating that STAT3 may be a promising therapeutic target in the treatment of malignant melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Ihor Arkhypov, Feyza Gul Ozbay Kurt, Rebekka Bitsch, Daniel Novak, Vera Petrova, Samantha Lasser, Thomas Hielscher, Christopher Groth, Alisa Lepper, Xiaoying Hu, Wei Li, Jochen Utikal, Peter Altevogt, Viktor Umansky
Summary: Soluble HSP90 alpha can convert monocytes into MDSC, which inhibits the antitumor function of T and NK cells. Higher levels of HSP90 alpha in plasma of patients with melanoma are associated with increased PD-L1 expression on MDSC and shorter PFS after ICI therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Nanoscience & Nanotechnology
Wenzhe Yang, Xue Pan, Peng Zhang, Xue Yang, Huashi Guan, Huan Dou, Qian Lu
Summary: A dual-administration paradigm involving transdermal and intravenous delivery was developed to reverse the hypoxic and immunosuppressive tumor microenvironment in the treatment of malignant melanoma. The Ato/cabo@PEG-TK-PLGA nanoparticles successfully penetrated the tumor and released atovaquone and cabozantinib, which reversed the hypoxic and immunosuppressive microenvironment, respectively.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Oncology
Guiqing Ding, Qianyi Gong, Jinyun Ma, Xiaojun Liu, Yuanhua Wang, Xiaodong Cheng
Summary: The study demonstrates that Astragalus polysaccharides can modulate the immune function in tumor-bearing mice by remodeling the gut microbiota, particularly by reducing the number of myeloid-derived suppressor cells. Results from 16S rRNA analysis show that APS significantly regulates various microorganisms, with changes in abundance related to the increase of metabolites that promote tumor growth.
Article
Engineering, Environmental
Jingxue Wang, Weixi Jiang, Mingxiao Fang, Chier Du, Xun Guo, Xiaoling Qiu, Xiaoting Wang, Yuanli Luo, Peng Tu, Chen Cheng, Pan Li, Haitao Ran, Jianli Ren
Summary: This study discovered a strategy for MCT blockage using a manganese-based metal organic framework to enhance chemodynamic immunotherapy. By lowering intracellular pH and increasing intracellular H2O2 levels, this strategy can promote the activation and proliferation of T cells. It also reduces lactate levels in the tumor microenvironment, restoring immune activity and effectively inhibiting tumor invasion and metastasis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Juliano T. Freitas, Jesus Lopez, Claudia Llorian, Mariana Boroni, Lidia Kos
Summary: Endothelin receptor B signaling plays a crucial role in the melanoma microenvironment, mediating immunosuppression that leads to tumor immune evasion. The presence of regulatory T cells and dendritic cells is significantly higher in K5-Edn3 tumors compared to control tumors. In vitro, Edn3 not only promotes Treg proliferation but also upregulates FOXP3 expression.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Toshiaki Nakano, Chao-Long Chen, I-Hsuan Chen, Hui-Peng Tseng, Kuei-Chen Chiang, Chia-Yun Lai, Li-Wen Hsu, Shigeru Goto, Chih-Che Lin, Yu-Fan Cheng
Summary: Accumulating evidence suggests the involvement of tumor-derived exosomes in HCC development and recurrence. The study explores the impact of miR-4669 overexpression on HCC and its clinical value in predicting treatment response and HCC recurrence. Overexpression of miR-4669 enhances migration ability, leads to sorafenib resistance, and generates an immunosuppressive tumor microenvironment. Exosomal miR-4669 has clinical value in predicting treatment response and assessing the risk of HCC recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Debonil Maity, Kaustav Bera, Yizeng Li, Zhuoxu Ge, Qin Ni, Konstantinos Konstantopoulos, Sean X. Sun
Summary: Cells migrating in vivo encounter microenvironments with varying physical properties, including fluid viscosity. Contrary to expectations, cells migrate faster in high viscosity media on 2-dimensional substrates. Water flux and actin dynamics play important roles in driving cell migration in high viscosity environments.
Article
Cell Biology
Justyna Mazurkiewicz, Aleksandra Simiczyjew, Ewelina Dratkiewicz, Magdalena Kot, Katarzyna Pietraszek-Gremplewicz, Dominika Wilk, Marcin Zietek, Rafal Matkowski, Dorota Nowak
Summary: This study provides a more in-depth understanding of the role of keratinocytes in the melanoma microenvironment, highlighting their unique secretome and mediators of invasive abilities, which could be utilized by cancer cells to support their invasion of surrounding tissues.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Jinglong Zhang, Fan Zhang, Kenneth I. Porter, Panshak P. Dakup, Shuwen Wang, Gavin P. Robertson, Shobhan Gaddameedhi, Jiyue Zhu
Summary: Telomerase activation is crucial for melanomagenesis, but is hindered by telomere dysfunction in mice. The study found that telomere dysfunction delays melanoma development and leads to DNA damage and genomic instability.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Satu Salmi, Kaisla Halinen, Anton Lin, Sanna Suikkanen, Otto Jokelainen, Eija Rahunen, Hanna Siiskonen, Sanna Pasonen-Seppanen
Summary: In melanoma, CD8+ and GrB+ lymphocytes were found to be more abundant in pT4 melanomas and lymph node metastases compared to primaries. A low GrB/CD8 ratio was associated with better recurrence-free survival in primary melanomas, suggesting that GrB+ lymphocytes may represent activated immunosuppressive lymphocytes.
Article
Oncology
Maulasri Bhatta, Gautam N. Shenoy, Jenni L. Loyall, Brian D. Gray, Meghana Bapardekar, Alexis Conway, Hans Minderman, Raymond J. Kelleher Jr, Beatriz M. Carreno, Gerald Linette, Leonard D. Shultz, Kunle Odunsi, Sathy Balu-Iyer, Koon Yan Pak, Richard B. Bankert
Summary: The study demonstrated that ExoBlock has high avidity for binding to PS, significantly blocking the immunosuppressive activity of human ovarian tumor and melanoma-associated exosomes in vitro. Additionally, ExoBlock enhanced T cell-mediated tumor suppression in both the X-mouse and OTX models, leading to reduction in tumor burden, metastasis, and circulating PS+ exosomes in tumor-bearing mice. These results suggest that targeting exosomal PS in TMEs using ExoBlock is a promising strategy to enhance antitumor T-cell responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Pharmacology & Pharmacy
Qi Zhang, Linbo Jin, Quanxin Jin, Qiang Wei, Mingyuan Sun, Qi Yue, Huan Liu, Fangfang Li, Honghua Li, Xiangshan Ren, Guihua Jin
Summary: The study found that DHA has inhibitory effects on the proliferation, migration, and metastasis of melanoma, and can also impact immune cells in the tumor microenvironment. This suggests that DHA may serve as a potential treatment for melanoma.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohd Farhan Siddiqui, Moon-Moo Kim
Summary: Melanin is a key pigment in skin and hair, with deficiency leading to various disorders. Enhancing melanin production at a genetic level could offer an effective and permanent solution for these disorders, with the gene SIRT7 potentially playing a crucial role in this process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Nanoscience & Nanotechnology
Yasmeen Ezzeldeen, Shady Swidan, Aliaa ElMeshad, Aya Sebak
Summary: This study aimed to fabricate HK transfersomes for topical treatment of melanoma, which showed potential to alleviate the immunosuppressive characteristics of the tumor and reduce the expression of stem-like cell markers. The optimized formula exhibited a mean size of 190 nm and highly negative surface charge, with promising results both in vitro and in combination with other drugs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)