A Membrane-Type-1 Matrix Metalloproteinase (MT1-MMP) – Discoidin Domain Receptor 1 Axis Regulates Collagen-Induced Apoptosis in Breast Cancer Cells

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

(2013) Hyung-Gu Kim et al.   ACS Chemical Biology

The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1

(2013) F. Z. Cader et al.   BLOOD

Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors

(2013) J. Sun et al.   CARCINOGENESIS

Rho-associated coiled-coil kinase (ROCK) signaling and disease

(2013) Alice V. Schofield et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases

(2013) Hsueh-Liang Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Inducible Factor 1 Regulation through Cross Talk between mTOR and MT1-MMP

(2013) T. Sakamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

HIF-1α up-regulates NDRG1 expression through binding to NDRG1 promoter, leading to proliferation of lung cancer A549 cells

(2013) Qiang Wang et al.   MOLECULAR BIOLOGY REPORTS

Development of a Highly Selective c-Src Kinase Inhibitor

(2012) Kristoffer R. Brandvold et al.   ACS Chemical Biology

Discoidin domain receptor tyrosine kinases: new players in cancer progression

(2012) Rajeshwari R. Valiathan et al.   CANCER AND METASTASIS REVIEWS

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Differentially expressed, variant U1 snRNAs regulate gene expression in human cells

(2012) D. O'Reilly et al.   GENOME RESEARCH

N-myc Downstream Regulated Gene 1 (NDRG1) Promotes Metastasis of Human Scirrhous Gastric Cancer Cells through Epithelial Mesenchymal Transition

(2012) Hiroki Ureshino et al.   PLoS One

Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

(2012) Stephanie C. Huelga et al.   Cell Reports

New and Paradoxical Roles of Matrix Metalloproteinases in the Tumor Microenvironment

(2012) Agnès Noël et al.   Frontiers in Pharmacology

Chipster: user-friendly analysis software for microarray and other high-throughput data

(2011) M Aleksi Kallio et al.   BMC GENOMICS

Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2−:H2O2 Ratio and Confers Anoikis Resistance to Tumors

(2011) Pengcheng Zhu et al.   CANCER CELL

NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma

(2011) Jun Cheng et al.   CANCER LETTERS

Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer

(2011) Zhi-Yu Chen et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Inhibition of Src Family Kinases and Receptor Tyrosine Kinases by Dasatinib: Possible Combinations in Solid Tumors

(2011) J. C. Montero et al.   CLINICAL CANCER RESEARCH

DDR1 Receptor Tyrosine Kinase Promotes Prosurvival Pathway through Notch1 Activation

(2011) Hyung-Gu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Warburg Effect That Arises in Tumor Cells Expressing Membrane Type-1 Matrix Metalloproteinase

(2011) Takeharu Sakamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-matrix adhesions in 3D

(2011) Jill S. Harunaga et al.   MATRIX BIOLOGY

MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis

(2011) E Maquoi et al.   ONCOGENE

Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate

(2011) M. J. Emanuele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional diversity of the hnRNPs: past, present and perspectives

(2010) Siew Ping Han et al.   BIOCHEMICAL JOURNAL

3D collagen type I matrix inhibits the antimigratory effect of doxorubicin

(2010) Emilie Millerot-Serrurot et al.   Cancer Cell International

Heterogeneous Nuclear Ribonucleoprotein H Blocks MST2-Mediated Apoptosis in Cancer Cells by Regulating a-raf Transcription

(2010) J. Rauch et al.   CANCER RESEARCH

Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment

(2010) D. Barkan et al.   CANCER RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patients

(2010) L-C Chen et al.   CELL DEATH AND DIFFERENTIATION

Epithelial-to-Mesenchymal Transitions and Circulating Tumor Cells

(2010) Arnaud Bonnomet et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Nuclear Organization and Dynamics of 7SK RNA in Regulating Gene Expression

(2010) Kannanganattu V. Prasanth et al.   MOLECULAR BIOLOGY OF THE CELL

Reducing background fluorescence reveals adhesions in 3D matrices

(2010) Kristopher E. Kubow et al.   NATURE CELL BIOLOGY

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics

(2009) David Rodríguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Correlation between MMPs and their inhibitors in breast cancer tumor tissue specimens and in cell lines with different metastatic potential

(2009) Rita CS Figueira et al.   BMC CANCER

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

hnRNP M interacts with PSF and p54nrb and co-localizes within defined nuclear structures

(2009) Marija Marko et al.   EXPERIMENTAL CELL RESEARCH

SecretedVersusMembrane-anchored Collagenases

(2009) Farideh Sabeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

(2009) Farideh Sabeh et al.   JOURNAL OF CELL BIOLOGY

Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures

(2009) H. Mizushima et al.   JOURNAL OF CELL SCIENCE

Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia

(2009) R. Poincloux et al.   JOURNAL OF CELL SCIENCE

A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data

(2009) Nuno L. Barbosa-Morais et al.   NUCLEIC ACIDS RESEARCH

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   PHYSIOLOGY

 -Actin is required for cytoskeletal maintenance but not development

(2009) I. A. Belyantseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells

(2009) Shi-Hua Liao et al.   PROTEOMICS

Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database

(2008) P. M. McGowan et al.   ANNALS OF ONCOLOGY

Transcriptional regulation of human small nuclear RNA genes

(2008) G JAWDEKAR et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Collagen I but not Matrigel matrices provide an MMP-dependent barrier to ovarian cancer cell penetration

(2008) Katharine L Sodek et al.   BMC CANCER

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib

(2008) Elizabeth Day et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Model-based variance-stabilizing transformation for Illumina microarray data

(2008) Simon M. Lin et al.   NUCLEIC ACIDS RESEARCH

Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis

(2008) S. Perumal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaching the basement membrane: who, when and how?

(2008) R. Grant Rowe et al.   TRENDS IN CELL BIOLOGY

Matrix metalloproteinases at cancer tumor–host interface

(2007) A NOEL et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Membrane type 1-matrix metalloproteinase: Substrate diversity in pericellular proteolysis☆

(2007) M BARBOLINA et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY