WIP1 Phosphatase as a Potential Therapeutic Target in Neuroblastoma

Mdm2 Deficiency Suppresses MYCN-Driven Neuroblastoma Tumorigenesis In Vivo

(2015) Zaowen Chen et al.   NEOPLASIA

MDM2-p53 Interaction in Paediatric Solid Tumours: Preclinical Rationale, Biomarkers and Resistance

(2014) Giuseppe Barone et al.   CURRENT DRUG TARGETS

Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging

(2014) Yunhua Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

(2014) Aidan G Gilmartin et al.   Nature Chemical Biology

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas

(2014) Liwei Zhang et al.   NATURE GENETICS

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

(2013) Petra Kleiblova et al.   JOURNAL OF CELL BIOLOGY

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

(2012) Elise Ruark et al.   NATURE

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

A Genome-Wide Search for Promoters That Respond to Increased MYCN Reveals Both New Oncogenic and Tumor Suppressor MicroRNAs Associated with Aggressive Neuroblastoma

(2011) J. M. Shohet et al.   CANCER RESEARCH

Functional Analysis of the p53 Pathway in Neuroblastoma Cells Using the Small-Molecule MDM2 Antagonist Nutlin-3

(2011) T. Van Maerken et al.   MOLECULAR CANCER THERAPEUTICS

The Wip1 phosphatase and Mdm2: Cracking the "Wip" on p53 stability

(2010) Xiongbin Lu et al.   CELL CYCLE

Dephosphorylation of γ-H2AX by WIP1: An important homeostatic regulatory event in DNA repair and cell cycle control

(2010) Sung-Hwan Moon et al.   CELL CYCLE

High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma

(2010) J. Carr-Wilkinson et al.   CLINICAL CANCER RESEARCH

Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair

(2010) Sung-Hwan Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14ARF-MDM2-p53 axis

(2009) T Van Maerken et al.   CELL DEATH AND DIFFERENTIATION

PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas

(2009) D. S.P. Tan et al.   CLINICAL CANCER RESEARCH

Antitumor Activity of the Selective MDM2 Antagonist Nutlin-3 Against Chemoresistant Neuroblastoma With Wild-Type p53

(2009) Tom Van Maerken et al.   JNCI-Journal of the National Cancer Institute

Targeted Molecular Therapy for Neuroblastoma: The ARF/MDM2/p53 Axis

(2009) Eugene Kim et al.   JNCI-Journal of the National Cancer Institute

Wip1 Regulates the Generation of New Neural Cells in the Adult Olfactory Bulb through p53-Dependent Cell Cycle Control

(2009) Yun-Hua Zhu et al.   STEM CELLS

Senescent Growth Arrest in Mesenchymal Stem Cells Is Bypassed by Wip1-Mediated Downregulation of Intrinsic Stress Signaling Pathways

(2009) Ji-Seon Lee et al.   STEM CELLS

WIP1 phosphatase at the crossroads of cancer and aging

(2009) Xavier Le Guezennec et al.   TRENDS IN BIOCHEMICAL SCIENCES

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53

(2007) Silvia Medrano et al.   NEUROBIOLOGY OF AGING