A Computational Strategy to Select Optimized Protein Targets for Drug Development toward the Control of Cancer Diseases

The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells

(2014) Michaël Boyer-Guittaut et al.   Autophagy

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics

(2014) Carlos L. Arteaga et al.   CANCER CELL

The HER2 peptide nelipepimut-S (E75) vaccine (NeuVax™) in breast cancer patients at risk for recurrence: correlation of immunologic data with clinical response

(2014) Erika J Schneble et al.   Immunotherapy

The Adaptor Proteins p66Shc and Grb2 Regulate the Activation of the GTPases ARF1 and ARF6 in Invasive Breast Cancer Cells

(2014) Eric Haines et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt

(2014) Pingping Wang et al.   MOLECULAR CELL

Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A

(2013) Daisuke Miwa et al.   ANGIOGENESIS

New network topology approaches reveal differential correlation patterns in breast cancer

(2013) Michael Bockmayr et al.   BMC Systems Biology

Epidermal Growth Factor Receptor Potentiates MCM7-Mediated DNA Replication through Tyrosine Phosphorylation of Lyn Kinase in Human Cancers

(2013) Tzu-Hsuan Huang et al.   CANCER CELL

Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer

(2013) B. Li et al.   CLINICAL CANCER RESEARCH

Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells

(2013) Yasuhito Ishigaki et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Potential role of Anxa1 in cancer

(2013) Chunmei Guo et al.   Future Oncology

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

Molecular Profiling of Multiple Human Cancers Defines an Inflammatory Cancer-Associated Molecular Pattern and Uncovers KPNA2 as a Uniform Poor Prognostic Cancer Marker

(2013) Saleh M. Rachidi et al.   PLoS One

Up-Regulation of Hepatoma-Derived Growth Factor Facilities Tumor Progression in Malignant Melanoma

(2013) Han-En Tsai et al.   PLoS One

Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity

(2013) F. Usuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a

(2013) L Huang et al.   Cell Death & Disease

Signaling Network Assessment of Mutations and Copy Number Variations Predict Breast Cancer Subtype-Specific Drug Targets

(2013) Naif Zaman et al.   Cell Reports

SRPK1 inhibitionin vivo: modulation of VEGF splicing and potential treatment for multiple diseases: Figure 1

(2012) Sebastian Oltean et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Loss of c-Met accelerates development of liver fibrosis in response to CCl4 exposure through deregulation of multiple molecular pathways

(2012) Jens U. Marquardt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Plakophilin-2: a cell-cell adhesion plaque molecule of selective and fundamental importance in cardiac functions and tumor cell growth

(2012) Steffen Rickelt   CELL AND TISSUE RESEARCH

A novel interaction of nucleophosmin with BCL2-associated X protein regulating death evasion and drug sensitivity in human hepatoma cells

(2012) Shao-Jung Lo et al.   HEPATOLOGY

IL-13–induced airway mucus production is attenuated by MAPK13 inhibition

(2012) Yael G. Alevy et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular signaling network complexity is correlated with cancer patient survivability

(2012) D. Breitkreutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eukaryotic elongation factor 1 complex subunits are critical HIV-1 reverse transcription cofactors

(2012) K. Warren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Regulation of epithelial to mesenchymal transition: CK2β on stage

(2011) Alexandre Deshiere et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Next-generation sequencing to generate interactome datasets

(2011) Haiyuan Yu et al.   NATURE METHODS

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

(2011) Aaron A Goodarzi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pathway discovery in metabolic networks by subgraph extraction

(2010) Karoline Faust et al.   BIOINFORMATICS

HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells

(2010) Han-Cheon Kim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Solution Structure of the Catalytic Domain of the Mitochondrial Protein ICT1 That Is Essential for Cell Vitality

(2010) Yoshihiro Handa et al.   JOURNAL OF MOLECULAR BIOLOGY

NFKBIADeletion in Glioblastomas

(2010) Markus Bredel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vimentin Is a Novel Anti-Cancer Therapeutic Target; Insights from In Vitro and In Vivo Mice Xenograft Studies

(2010) Guy Lahat et al.   PLoS One

Complex Networks and Symmetry I: A Review

(2010) Diego Garlaschelli et al.   Symmetry-Basel

Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice

(2009) Weidong Cao et al.   APOPTOSIS

Structural aspects of RNA helicases in eukaryotic mRNA decay

(2009) Sharon H. M. Ling et al.   BIOSCIENCE REPORTS

Regulatory Mimicry in Listeria monocytogenes Actin-Based Motility

(2009) Ryan Chong et al.   Cell Host & Microbe

Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response

(2009) Jiao Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Antibodies targeting hepatoma-derived growth factor as a novel strategy in treating lung cancer

(2009) H. Ren et al.   MOLECULAR CANCER THERAPEUTICS

Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage

(2009) N. F. Krynetskaia et al.   MOLECULAR CANCER THERAPEUTICS

CK2β Is Expressed in Endometrial Carcinoma and Has a Role in Apoptosis Resistance and Cell Proliferation

(2008) Judit Pallares et al.   AMERICAN JOURNAL OF PATHOLOGY

Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate

(2008) Howard Kendrick et al.   BMC GENOMICS

Inhibition of heregulin mediated MCF-7 breast cancer cell growth by the ErbB3 binding protein EBP1

(2008) Yuexing Zhang et al.   CANCER LETTERS

Interaction of heat-shock protein 90β isoform (HSP90β) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation

(2008) C Didelot et al.   CELL DEATH AND DIFFERENTIATION

Symmetry in complex networks

(2008) Ben D. MacArthur et al.   DISCRETE APPLIED MATHEMATICS

Using fluorodeoxythymidine to monitor anti-EGFR inhibitor therapy in squamous cell carcinoma xenografts

(2008) David M. Atkinson et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS

NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells

(2008) W Qi et al.   ONCOGENE