Structure-Based Virtual Screening and Discovery of New PPARδ/γ Dual Agonist and PPARδ and γ Agonists

Consensus Docking: Improving the Reliability of Docking in a Virtual Screening Context

(2013) Douglas R. Houston et al.   Journal of Chemical Information and Modeling

Ligand- and Structure-Based Drug Design Strategies and PPARδ/α Selectivity

(2012) Vinícius G. Maltarollo et al.   Chemical Biology & Drug Design

PPAR agonists for the treatment of cardiovascular disease in patients with diabetes

(2012) J. P. H. Wilding   DIABETES OBESITY & METABOLISM

ZINC: A Free Tool to Discover Chemistry for Biology

(2012) John J. Irwin et al.   Journal of Chemical Information and Modeling

Advanced QSAR studies on PPARδ ligands related to metabolic diseases

(2012) Vinícius G. Maltarollo et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Managing the Dyslipidemia of Metabolic Syndrome: Beyond Statin Therapy

(2012) Ishwarlal Jialal et al.   Metabolic Syndrome and Related Disorders

Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders

(2012) Yu-Chang Chen et al.   MOLECULAR NEUROBIOLOGY

The intestinal bioavailability of vaccenic acid and activation of peroxisome proliferator-activated receptor-α and -γ in a rodent model of dyslipidemia and the metabolic syndrome

(2012) Ye Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Phenoxyacetic acids as PPARδ partial agonists: Synthesis, optimization, and in vivo efficacy

(2011) Karen A. Evans et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) γ/δ Agonists with High Potency and in vivo Efficacy

(2011) Stefanie Keil et al.   ChemMedChem

Rational Targeting of Peroxisome Proliferating Activated Receptor Subtypes

(2011) D. K. Nevin et al.   CURRENT MEDICINAL CHEMISTRY

PPAR gamma, bioactive lipids, and cancer progression

(2011) Gregory et al.   Frontiers in Bioscience-Landmark

Peroxisome Proliferator-Activated Receptor-γ Regulates Inflammation and Renin-Angiotensin System Activity in the Hypothalamic Paraventricular Nucleus and Ameliorates Peripheral Manifestations of Heart Failure

(2011) Yang Yu et al.   HYPERTENSION

PPAR-Gamma Agonist Rosiglitazone Attenuates the Inflammation Caused by Carrageenan in the Mouse Model of Pleurisy

(2011) Ziliani da Silva Buss et al.   INFLAMMATION

Structural Basis for Iloprost as a Dual Peroxisome Proliferator-activated Receptor α/δ Agonist

(2011) Lihua Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Role of physicochemical properties in the activation of peroxisome proliferator-activated receptor δ

(2011) Vinícius G. Maltarollo et al.   JOURNAL OF MOLECULAR MODELING

Two-dimensional quantitative structure-activity relationship studies on bioactive ligands of peroxisome proliferator-activated receptor δ

(2011) Tábata S. Garcia et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Docking and Molecular Dynamics Simulations of Peroxisome Proliferator Activated Receptors Interacting with Pan Agonist Sodelglitazar

(2011) Xu-Yuan Liu et al.   PROTEIN AND PEPTIDE LETTERS

Structural requirement for PPARγ binding revealed by a meta analysis of holo-crystal structures

(2010) Alessandro S. Nascimento   BIOCHIMIE

Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists

(2010) Christopher A. Luckhurst et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures

(2009) Takuji Oyama et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Identification of a PPARδ agonist with partial agonistic activity on PPARγ

(2009) Richard V. Connors et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease

(2009) Emma Robinson et al.   PHARMACOLOGY & THERAPEUTICS

A QSAR Study on Indole-Based PPAR-γ Agonists in Respect to Receptor Binding and Gene Transactivation Data

(2009) Costas Giaginis et al.   Quantitative structure-activity relationships & combinatorial science

QSAR Models for Prediction of PPARδ Agonistic Activity of Indanylacetic Acid Derivatives

(2009) Viney Lather et al.   Quantitative structure-activity relationships & combinatorial science

Discovery of a novel class of PPARδ partial agonists

(2008) Barry G. Shearer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

(2008) D. R. Artis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Pro-inflammatory Adhesion Molecules by PPAR-δ in Human Vascular Endothelial Cells

(2007) Yanbo Fan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY