Article
Medicine, General & Internal
Rebecka Papaioannu Borjesson, Laura Galli, Camilla Muccini, Andrea Poli, Tommaso Clemente, Martina Bottanelli, Nicola Gianotti, Silvia Nozza, Antonella Castagna, Vincenzo Spagnuolo
Summary: This study analyzed the impact of the COVID-19 pandemic on the prevalence and incidence of metabolic syndrome in people living with HIV. The results showed an increase in both the prevalence and incidence of metabolic syndrome during the pandemic period.
FRONTIERS IN MEDICINE
(2023)
Article
Nutrition & Dietetics
Joanna Popiolek-Kalisz
Summary: Metabolic syndrome (MetS) is caused by central obesity and leads to chronic inflammation, hypertension, diabetes, and dyslipidemia. This study analyzed the differences in flavonol intake between MetS patients and healthy participants, finding that MetS patients consumed significantly less flavonols, particularly from tomatoes. There was a moderate inverse correlation between flavonol consumption and MetS stage, suggesting a potential protective effect against MetS.
Review
Chemistry, Medicinal
Azar Hosseini, Bibi Marjan Razavi, Maciej Banach, Hossein Hosseinzadeh
Summary: Quercetin, as an important flavonoid, has potential effects in improving symptoms of metabolic syndrome, but further research and clinical trials are needed to determine its true clinical value.
PHYTOTHERAPY RESEARCH
(2021)
Review
Food Science & Technology
Ana Maria Garcia-Munoz, Ana I. Garcia-Guillen, Desiree Victoria-Montesinos, Maria Salud Abellan-Ruiz, Begona Alburquerque-Gonzalez, Fernando Canovas
Summary: Metabolic syndrome is linked to increased risks of cardiovascular disease and type 2 diabetes, further exacerbated by a sedentary lifestyle and situations like the COVID-19 pandemic. Recent studies suggest that consumption of polyphenol-rich fruits and vegetables has a protective effect in reducing cardiovascular risk. Hibiscus sabdariffa (HS) in combination with other plant extracts has been gaining attention for its potential in treating metabolic syndrome. A systematic review and meta-analysis of randomized clinical trials were conducted to examine the effects of HS with other plant extracts on metabolic syndrome prevention, revealing improvements in anthropometric parameters, blood pressure, and lipid profile.
Review
Medicine, General & Internal
Michal Wicinski, Anna Fajkiel-Madajczyk, Zuzanna Kurant, Karol Gryczka, Dominik Kurant, Monika Szambelan, Bartosz Malinowski, Michal Falkowski, Jan Zabrzynski, Maciej Slupski
Summary: Cannabis-derived therapies, particularly cannabidiol (CBD), have shown potential in the treatment of metabolic syndrome components such as obesity, impaired glucose and lipid metabolism, high blood pressure, and NAFLD. CBD has been found to have positive effects on glucose homeostasis, lipid disorders, and hypertension, but more research is needed. Limited data on CBD and NAFLD in human studies make it unclear whether CBD is beneficial for this condition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Chaojun Yang, Xiaocan Jia, Yuping Wang, Jingwen Fan, Chenyu Zhao, Yongli Yang, Xuezhong Shi
Summary: This study examines the prevalence, intervention, and control of metabolic syndrome (MetS) among US adults from 1999 to 2018, finding a significant increase in MetS prevalence during this time period. Factors such as smoking and vigorous activity were found to influence MetS prevalence. Elevated blood glucose and obesity were identified as the main causes of MetS burden. The study suggests that targeting specific populations for treatment and lifestyle modification could improve the control of blood glucose and obesity.
Review
Nutrition & Dietetics
Marta Pelczynska, Malgorzata Moszak, Pawel Bogdanski
Summary: Magnesium is an essential nutrient for maintaining vital physiological functions, and its deficiency may lead to metabolic disorders associated with obesity. High magnesium intake through diet and/or supplementation can prevent chronic metabolic complications by limiting adipose tissue accumulation and improving glucose and insulin metabolism. However, more randomized controlled trials are needed to evaluate magnesium supplementation strategies.
Review
Biochemistry & Molecular Biology
Roxana Nartea, Brindusa Ilinca Mitoiu, Ioana Ghiorghiu
Summary: Many investigations have found a link between statins and magnesium supplements. Hypomagnesemia may be a key factor in the development of metabolic illnesses such as obesity, diabetes, hypertension, and inflammation, while statins lower the frequency of cardiovascular events and mortality through mevalonate reduction and improving endothelial function. A comprehensive analysis comparing the effects of Mg-2 and statins on lipoproteins and cholesterol metabolism was conducted.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Medicine, General & Internal
Amedeo Tirandi, Federico Carbone, Fabrizio Montecucco, Luca Liberale
Summary: Metabolic syndrome is a common condition with harmful effects on the cardiovascular system, particularly associated with sudden cardiac death. The disease is influenced by genetic predisposition, unhealthy lifestyle, and aging, leading to chronic low-grade inflammation and other cardiovascular problems.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Multidisciplinary Sciences
Basma H. Sobieh, Hala O. El-Mesallamy, Dina H. Kassem
Summary: Osteoarthritis (OA) is a prevalent progressive disease frequently associated with obesity. Recent findings have revealed the important role of adipose tissue in OA pathogenesis, shifting the perspective from aging and mechanical stress to metabolic effects of obesity on cartilage tissue. Adipokines such as metrnl and retinol-binding protein 4 (RBP4) have emerged as significant mediators in the development of OA. This review summarizes the latest research on the metabolic contribution of obesity in OA pathogenesis, with a focus on dyslipidemia, insulin resistance, and adipokines.
Article
Pharmacology & Pharmacy
Blanca Gavilan-Carrera, Alberto Soriano-Maldonado, Juan Diego Mediavilla-Garcia, Carl J. Lavie, Jose Antonio Vargas-Hitos
Summary: Statin-associated muscle symptoms (SAMS) are common in patients using statin drugs, but not all symptoms are caused by the drugs, negative expectations could also play a role. Physical activity is important for managing cardiovascular disease risk, but the evidence of increased creatine-kinase levels in statin-treated athletes has been wrongly generalized. The potential of reducing sedentary behavior and resistance training has been overlooked in current guidelines.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mia J. Coleman, Luis M. Espino, Hernan Lebensohn, Marija Zimkute, Negar Yaghooti, Christina L. Ling, Jessica M. Gross, Natalia Listwan, Sandra Cano, Vanessa Garcia, Debbie M. Lovato, Susan L. Tigert, Drew R. Jones, Rama R. Gullapalli, Neal E. Rakov, Euriko G. Torrazza Perez, Eliseo F. Castillo
Summary: This study evaluated intestinal health in human subjects with metabolic syndrome (MetS) and found significant alterations in fecal lipid profiles in MetS patients, potentially occurring before the onset of gut inflammation or increased intestinal permeability. Additionally, fecal metabolomics was identified as a non-invasive, accurate screening method for both MetS and non-alcoholic fatty liver disease (NAFLD).
Article
Nutrition & Dietetics
Jonas Ellerbrock, Esmee Hubers, Chahinda Ghossein-Doha, Veronique Schiffer, Robert-Jan Alers, Laura Jorissen, Jolijn van Neer, Maartje Zelis, Emma Janssen, Sabine Landewe-Cleuren, Annemie van Haarlem, Boris Kramer, Marc Spaanderman
Summary: This study evaluated the association between gestational diabetes mellitus (GDM), metabolic syndrome (MetS) constituents, and pregnancy outcomes. The study found that factors such as hypertension, dyslipidemia, and proteinuria were associated with an increased risk of preeclampsia and preterm birth, while obesity was not related to adverse outcomes.
Article
Multidisciplinary Sciences
Malihe Aghasizadeh, Saeede Khosravi Bizhaem, Mahin Baniasadi, Mohammad Reza Khazdair, Toba Kazemi
Summary: The study revealed that over half of the population were in the very-high CVD risk group, with 57.6% falling into this category. The proportion of patients meeting total LDL-C goal values according to the guidelines was 43.4%, with the highest achievement seen in patients using moderate-intensity statin therapy.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Reyna Rodriguez-Mortera, Russell Caccavello, Ricardo Hermo, Maria Eugenia Garay-Sevilla, Alejandro Gugliucci
Summary: In a study comparing obese adolescents to lean controls, it was found that obese participants exhibited higher levels of hepcidin, ferritin, and IL-6. Differences in iron metabolism markers were not significant between the two groups except for ferritin. Hepcidin levels in obese adolescents were more correlated with inflammation and metabolic alterations than with iron metabolism.
