Review
Gastroenterology & Hepatology
James Richards, Alex Gimson, Yexin Joh, Christopher J. E. Watson, James Neuberger
Summary: Liver transplantation has evolved from a pioneering stage to routine medical care over the past 5 decades. However, there are still significant challenges in addressing unmet needs and questions in clinical trials to improve patient outcomes. Solutions such as validated surrogate endpoints, collaborative studies, recognition of larger research projects, individual research areas, and fair funding structures are suggested to overcome these challenges.
LIVER TRANSPLANTATION
(2021)
Review
Biochemistry & Molecular Biology
Daniel-Clement Osei-Bordom, Sivesh Kamarajah, Niki Christou
Summary: In the clinical management of liver metastasis of colorectal cancer, surgeons and oncologists categorize the metastasis into resectable and non-resectable groups to initiate tailored therapeutics. The combination of targeted therapies and biotherapies around these two entities is being actively explored to determine the ideal conditions for their application to improve patient survival and quality of life.
Review
Oncology
Alexandra Nassar, Stylianos Tzedakis, Alix Dhote, Marie Strigalev, Romain Coriat, Mehdi Karoui, Anthony Dohan, Martin Gaillard, Ugo Marchese, David Fuks
Summary: This literature review aimed to assess the feasibility of laparoscopic liver resection for multiple colorectal liver metastases. The minimally invasive approach for liver cancer has become a new standard of oncological care, and laparoscopic liver resection is a significant indication for multiple colorectal liver metastases. The purpose of this paper was to highlight the novelty and updates in the field of multiple minimally invasive liver resections and discuss the feasibility and outcomes of laparoscopic concomitant multiple liver resections for colorectal liver metastases.
Review
Cell Biology
Diamantis I. Tsilimigras, Ioannis Ntanasis-Stathopoulos, Timothy M. Pawlik
Summary: The liver is a common site for metastasis in colorectal cancer patients due to the direct connection between the colon and rectum and the liver through the portal vein circulation. The liver tumor microenvironment consists of different cell types that modulate antigen recognition and immune system activation. Primary tumors from other sites create a pre-metastatic niche in the liver before the seeding of cancer cells. There are four key phases in the development of liver metastases: microvascular infiltration, extravascular pre-angiogenesis, angiogenesis, and tumor growth.
Article
Surgery
Jenna N. Whitrock, Stephen J. Hartman, Shimul A. Shah
Summary: In patients with unresectable liver metastases from colorectal cancer, chemotherapy alone is associated with significant mortality. Liver transplant is emerging as a promising treatment alternative for appropriately selected patients. Several key clinical trials, including SECA-I and SECA-II, have demonstrated promising survival outcomes, and further trials are ongoing to evaluate the safety of this approach.
Review
Biochemistry & Molecular Biology
Carolin Czauderna, Kim Luley, Nikolas von Bubnoff, Jens U. Marquardt
Summary: Liver metastases are the most common site of metastasis in colorectal cancer. Current treatment approaches involve systemic therapies and surgical/interventional strategies, with the use of predictive and prognostic biomarkers leading to improved survival rates. Treatment selection based on patient status, tumor characteristics, and molecular/genetic status is recommended for better outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Drew Maclean, Maria Tsakok, Fergus Gleeson, David J. Breen, Robert Goldin, John Primrose, Adrian Harris, James Franklin
Summary: Colorectal liver metastases exhibit heterogenous histopathological and immunohistochemical phenotypes, impacting treatment responses and outcomes. Advanced imaging techniques like multiparametric MRI and functional imaging have the potential to provide clinically-actionable phenotypic characterisation. Advanced analysis techniques such as radiomics and machine learning play a growing role in linking imaging features to clinically relevant tumour phenotypes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Dongchan Kim, Bhavya Gupta, Geoffrey Yuet Mun Wong
Summary: The liver is the most common site of metastasis in colorectal cancer. Multimodal treatment, including liver resection, is potentially curative and prolongs survival for selected patients with colorectal liver metastases (CRLM). However, the treatment of CRLM remains challenging because recurrence is common, and prognosis varies widely between patients despite curative-intent treatment. Clinicopathological features and tissue-based molecular biomarkers, either alone or in combination, are insufficient for accurate prognostication. As most of the functional information in cells resides in the proteome, circulating proteomic biomarkers may be useful for rationalising the molecular complexities of CRLM and identifying potentially prognostic molecular subtypes. High-throughput proteomics has accelerated a range of applications including protein profiling of liquid biopsies for biomarker discovery. Moreover, these proteomic biomarkers may provide non-invasive prognostic information even before CRLM resection. This review evaluates recently discovered circulating proteomic biomarkers in CRLM. We also highlight some of the challenges and opportunities with translating these discoveries into clinical applications. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Serban Puia-Negulescu, Fanny Lebosse, Jean-Yves Mabrut, Xavier Muller, Guillaume Rossignol, Teresa Antonini, Domitille Erard, Sylvie Radenne, Marielle Guillet, Jean-Christophe Souquet, Kayvan Mohkam, Mickael Lesurtel
Summary: Liver transplantation for patients with nonresectable liver metastases from colorectal cancer, although historically perceived poorly, is being revisited due to recent advances in chemotherapy and immunosuppression. Promising results have been shown in new data, which are currently undergoing validation in ongoing clinical trials. Given the scarcity of liver grafts, new tools are being explored to expand the donor pool for this indication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Computer Science, Information Systems
Joanna Harton, Nandita Mitra, Rebecca A. Hubbard
Summary: The study found that using biomarker values collected at informative and noninformative visits can reduce bias when the biomarker is stable over time, but may lead to substantial bias when it is volatile. Adjusting for the number of prior visits within a fixed look-back window can help mitigate bias to some extent, but not eliminate it completely. Bias may frequently occur in common scenarios and adjusting for prior visit intensity may not always be effective in eliminating it.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Chemistry, Multidisciplinary
Hang Sun, Lejia Sun, Xindi Ke, Lijuan Liu, Changcan Li, Bao Jin, Peipei Wang, Zhuoran Jiang, Hong Zhao, Zhiying Yang, Yongliang Sun, Jianmei Liu, Yan Wang, Minghao Sun, Mingchang Pang, Yinhan Wang, Bin Wu, Haitao Zhao, Xinting Sang, Baocai Xing, Huayu Yang, Pengyu Huang, Yilei Mao
Summary: This study introduces an innovative patient-derived tumor model for colorectal cancer and its liver metastases using 3D bioprinting technology. The tumor models effectively retain parental tumor biomarkers and mutation profiles and demonstrate substantial tumor heterogeneity. In vitro tests reveal a strong correlation between drug testing and clinical response, highlighting the potential of 3D bioprinting tumor models for personalized cancer therapy.
Article
Chemistry, Multidisciplinary
Zhaozhong Wang, Chen Chen, Chongdeng Shi, Xiaotian Zhao, Lin Gao, Feiyue Guo, Maosen Han, Zhenmei Yang, Jing Zhang, Chunwei Tang, Cai Zhang, Ying Liu, Peng Sun, Xinyi Jiang
Summary: Neutrophil extracellular traps (NETs) are web-like chromatin structures coated with granule proteins that can trap microorganisms. However, they can also cause damage to host tissue and contribute to the development of various diseases. Researchers developed biomimetic CCDC25-overexpressing cell membrane hybrid liposomes that specifically target NETs and efficiently eliminate them, providing a promising therapeutic approach for NET-associated diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Vincenza Granata, Roberta Fusco, Antonio Avallone, Alfonso De Stefano, Alessandro Ottaiano, Carolina Sbordone, Luca Brunese, Francesco Izzo, Antonella Petrillo
Summary: This study evaluated the association of RAS mutation status and radiomics-derived data using CE-MRI in liver metastases. Texture parameters derived by CE-MRI showed better results compared to morphological metrics in individualized evaluation of CRLM. Multivariate analysis and pattern recognition approaches allowed stratifying the patients according to RAS mutation status.
Review
Biochemistry & Molecular Biology
Geoffrey Yuet Mun Wong, Connie Diakos, Thomas J. Hugh, Mark P. Molloy
Summary: Colorectal liver metastases (CRLM) are a major cause of death in patients with metastatic colorectal cancer (CRC). Liver resection is the main treatment for select patients with CRLM, but effective treatment remains challenging due to high rates of recurrence. Genomic profiling has improved our understanding of CRC, but the functional context at the protein level is not well-established. Proteomic biomarkers are being explored for predicting CRLM and recurrence. This review aims to rationalize the proteomic complexity of CRC and explore the potential applications of proteomic biomarkers in CRLM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Rohin Gawdi, Cristian D. Valenzuela, Omeed Moaven, John A. Stauffer, Nico R. Del Piccolo, Tanto Cheung, Carlos U. Corvera, Andrew D. Wisneski, Charles Cha, Perry Shen, Greg Russell, Nima Zarandi, Justin Dourado
Summary: This study examined the impact of neoadjuvant, adjuvant, and perioperative chemotherapy on the outcomes of patients with resectable colorectal-liver metastases (CLM). The results showed that adjuvant and perioperative chemotherapy were independently associated with improved overall survival (OS) compared to surgery alone.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemical Research Methods
Jagdish Mahale, Lynne M. Howells, Rajinder Singh, Robert G. Britton, Hong Cai, Karen Brown
BIOMEDICAL CHROMATOGRAPHY
(2018)
Article
Food Science & Technology
Michael T. Empl, Hong Cai, Shan Wang, Johannes Junginger, Tina Kostka, Marion Hewicker-Trautwein, Karen Brown, Andreas J. Gescher, Pablo Steinberg
MOLECULAR NUTRITION & FOOD RESEARCH
(2018)
Article
Food Science & Technology
Jagdish Mahale, Rajinder Singh, Lynne M. Howells, Robert G. Britton, Sameena M. Khan, Karen Brown
MOLECULAR NUTRITION & FOOD RESEARCH
(2018)
Article
Cell Biology
Ni Ni Moe Myint, Ajay M. Verma, Daniel Fernandez-Garcia, Panchali Sarmah, Patrick S. Tarpey, Saif Sattar Al-Aqbi, Hong Cai, Ricky Trigg, Kevin West, Lynne M. Howells, Anne Thomas, Karen Brown, David S. Guttery, Baljit Singh, Howard J. Pringle, Ultan McDermott, Jacqui A. Shaw, Alessandro Rufini
CELL DEATH & DISEASE
(2018)
Article
Multidisciplinary Sciences
Constantinos Alexandrou, Saif Sattar Al-Aqbi, Jennifer A. Higgins, William Boyle, Ankur Karmokar, Catherine Andreadi, Jin-Li Luo, David A. Moore, Maria Viskaduraki, Matthew Blades, Graeme I. Murray, Lynne M. Howells, Anne Thomas, Karen Brown, Paul N. Cheng, Alessandro Rufini
SCIENTIFIC REPORTS
(2018)
Review
Environmental Sciences
L. H. Pottenger, G. Boysen, K. Brown, J. Cadet, R. P. Fuchs, G. E. Johnson, J. A. Swenberg
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2019)
Review
Oncology
Christopher P. Wild, Carolina Espina, Linda Bauld, Bernardo Bonanni, Hermann Brenner, Karen Brown, Joakim Dillner, David Forman, Ellen Kampman, Mef Nilbert, Karen Steindorf, Hans Storm, Paolo Vineis, Michael Baumann, Joachim Schuez
MOLECULAR ONCOLOGY
(2019)
Review
Oncology
Davide Serrano, Bernardo Bonanni, Karen Brown
MOLECULAR ONCOLOGY
(2019)
Article
Nutrition & Dietetics
Lynne M. Howells, Chinenye O. O. Iwuji, Glen R. B. Irving, Shaun Barber, Harriet Walter, Zahirah Sidat, Nicola Griffin-Teall, Rajinder Singh, Nalini Foreman, Samita R. Patel, Bruno Morgan, William P. Steward, Andreas Geseher, Anne L. Thomas, Karen Brown
JOURNAL OF NUTRITION
(2019)
Article
Biochemistry & Molecular Biology
Gintare Smagurauskaite, Jagdish Mahale, Karen Brown, Anne L. Thomas, Lynne M. Howells
Article
Endocrinology & Metabolism
Suping Ling, Karen Brown, Joanne K. Miksza, Lynne Howells, Amy Morrison, Eyad Issa, Thomas Yates, Kamlesh Khunti, Melanie J. Davies, Francesco Zaccardi
Review
Cardiac & Cardiovascular Systems
Suping Ling, Karen Brown, Joanne K. Miksza, Lynne M. Howells, Amy Morrison, Eyad Issa, Thomas Yates, Kamlesh Khunti, Melanie J. Davies, Francesco Zaccardi
Summary: This study found that the relative risk of cancer incidence and mortality associated with diabetes changed over time; the relative risk of cancer incidence increased between 1980 and 2000 and then stabilized, while the relative risk of cancer mortality remained constant at around 1.2. Different cancer sites showed varied trends in relative risk changes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Nutrition & Dietetics
Hong Cai, Edwina N. Scott, Robert G. Britton, Emma Parrott, Ted J. Ognibene, Michael Malfatti, Masood Khan, William P. Steward, Karen Brown
Summary: The study found that concentrations of resveratrol in prostate tissue were low after dietary-achievable or pharmacological doses, with mainly metabolites detected rather than resveratrol itself. Although resveratrol reduced prostate cell numbers in vitro, the concentrations required were higher than plasma maximum concentration.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Suping Ling, Francesco Zaccardi, Eyad Issa, Melanie J. Davies, Kamlesh Khunti, Karen Brown
Summary: The aim of this study was to examine long-term trends in cancer mortality rates among individuals with type 2 diabetes, based on various demographic and risk factor subgroups. The results showed that while overall mortality rates decreased, cancer mortality rates increased in older individuals with type 2 diabetes, especially for colorectal, pancreatic, liver, and endometrial cancer. This highlights the need for tailored cancer prevention and early detection strategies to address disparities in the older population, individuals of lower socioeconomic status, and smokers.
Review
Health Policy & Services
David Forman, Linda Bauld, Bernardo Bonanni, Hermann Brenner, Karen Brown, Joakim Dillner, Ellen Kampman, Marta Manczuk, Elio Riboli, Karen Steindorf, Hans Storm, Carolina Espina, Christopher P. Wild
JOURNAL OF CANCER POLICY
(2018)