Review
Oncology
Jean A. Klastersky
Summary: This review discusses the main approaches for lung control and highlights the differences between Central Europe and other countries. The three main approaches include smoking ban, early CT screening, and access to novel therapies. Central Europe countries need to make significant efforts in all three approaches, requiring strong involvement from political authorities.
CURRENT OPINION IN ONCOLOGY
(2022)
Article
Substance Abuse
Mirte A. G. Kuipers, Paulien A. W. Nuyts, Marc C. Willemsen, Anton E. Kunst
Summary: Tobacco retailer licencing is recommended as an effective tobacco control strategy in Europe, with the potential to reduce smoking through better enforcement of existing policies, reducing the number of tobacco outlets, and denormalising tobacco. Licencing systems can vary in form, with some countries implementing expensive licences and strict criteria. Adoption of licencing may depend on public health or economic reasons, with cases showing success in countries like Finland and Hungary, while facing challenges in countries like Norway and Scotland.
Editorial Material
Oncology
Eric Solary, Patricia Blanc, Michael Boutros, Charis Girvalaki, Franco Locatelli, Rene H. Medema, Peter Nagy, Josep Tabernero
Summary: UNCAN.eu is a European initiative aimed at advancing cancer research through the creation of a research data hub, leading to new developments in cancer care.
Review
Dermatology
V Del Marmol
Summary: Euromelanoma is an organization dedicated to raising awareness of prevention, diagnosis, and treatment of skin cancer. They promote public awareness through screening campaigns and provide resources for education. They also facilitate collaborations and collect data for scientific research. Since 1999, they have expanded their efforts globally and gathered a substantial amount of skin cancer data.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Engineering, Chemical
Petr Travnicek, Petr Junga, Lubos Kotek, Tomas Vitez
Summary: The article addresses the issue of process safety in municipal wastewater treatment plants, creating a database of 232 accidents and analyzing their causes, consequences, and prevention methods. The most common cause of accidents is device or structural failure, with environmental damage being the most frequent consequence. Extreme weather conditions account for 13% of all accidents at WWTPs, indicating a need for operators to prepare for an increase in such incidents.
JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
(2022)
Article
Oncology
Nadine Zielonke, Lindy M. Kregting, Eveline A. M. Heijnsdijk, Piret Veerus, Sirpa Heinavaara, Martin McKee, Inge M. C. M. de Kok, Harry J. de Koning, Nicolien T. van Ravesteyn
Summary: The study found that if all European countries biennially screen all women aged 50 to 69 for breast cancer, despite the existing impact of breast cancer screening in Europe, there are still a significant number of breast cancer deaths that could be prevented. By increasing screening coverage, the breast cancer mortality rate in Europe can be substantially reduced.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Public, Environmental & Occupational Health
Petra Schoenweger, Michaela Kirschneck, Katharina Biersack, Anna-Francesca Di Meo, Philipp Reindl-Spanner, Barbara Prommegger, Claudia Ditzen-Janotta, Peter Henningsen, Helmut Krcmar, Jochen Gensichen, Caroline Jung-Sievers, P. O. K. A. L. Grp POKAL Grp
Summary: This scoping review provides an evidence base of existing and novel community-level indicators that are associated with mental health. Community factors related to the physical and social environment should be routinely recorded and considered as influencing factors or potentially underestimated confounders and should be analyzed and included in clinical outcomes, data, monitoring, and surveillance as they may reveal new trends and targets for public mental health interventions.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Pediatrics
Joan K. Morris, Marie-Claude Addor, Elisa Ballardini, Ingeborg Barisic, Laia Barrachina-Bonet, Paula Braz, Clara Cavero-Carbonell, Elly Den Hond, Ester Garne, Miriam Gatt, Martin Haeusler, Babak Khoshnood, Nathalie Lelong, Agnieszka Kinsner-Ovaskainen, Sonja Kiuru-Kuhlefelt, Kari Klungsoyr, Anna Latos-Bielenska, Elizabeth Limb, Mary T. O'Mahony, Isabelle Perthus, Anna Pierini, Judith Rankin, Anke Rissmann, Florence Rouget, Gerardine Sayers, Antonin Sipek, Sarah Stevens, David Tucker, Christine Verellen-Dumoulin, Hermien E. K. de Walle, Diana Wellesley, Wladimir Wertelecki, Eva Bermejo-Sanchez
Summary: The study suggests that the failure to implement mandatory folic acid fortification in the 28 European countries has led to neural tube defects occurring in nearly 1,000 pregnancies every year.
FRONTIERS IN PEDIATRICS
(2021)
Article
Parasitology
Marta Baxarias, Josep Homedes, Cristina Mateu, Charalampos Attipa, Laia Solano-Gallego
Summary: This study investigated the preventive measures and serological screening tools used in dogs for L. infantum infection in various European countries from 2012 to 2018. The results showed that repellents were the most commonly used preventive measure, followed by vaccines and Leisguard (R). In the clinical setting, there seems to be a preference for rapid tests to detect specific L. infantum antibodies, while ELISA or IFI are less often employed.
PARASITES & VECTORS
(2022)
Article
Medicine, General & Internal
Ki-Jin Ryu, Min Sun Kim, Ji Yoon Lee, Seunghyun Nam, Hye Gyeong Jeong, Tak Kim, Hyuntae Park
Summary: This study conducted a nationwide retrospective longitudinal cohort study in Korea to investigate the association of tamoxifen use with the risk of endometrial cancer and other uterine diseases in premenopausal women with breast cancer. The study found that tamoxifen use was significantly associated with an increased risk of endometrial hyperplasia, polyps, carcinoma, and other uterine cancers.
Article
Biochemistry & Molecular Biology
F. C. Malcomson, J. C. Mathers
Summary: Personalised and precision nutrition uses individual characteristics and responses to nutrients, foods, and dietary patterns to develop targeted nutritional advice for improving health. This approach is moving away from the 'one size fits all' model and may have potential for better population health and disease prevention. While most efforts have focused on obesity and cardiovascular diseases, there is a need to apply personalised and precision nutrition approaches in cancer prevention and for cancer survivors, taking advantage of the understanding of dietary factors, genetics, and the microbiome.
Article
Oncology
Claudia Santucci, Linia Patel, Matteo Malvezzi, Cezary Wojtyla, Carlo La Vecchia, Eva Negri, Paola Bertuccio
Summary: In Europe, there has been a favorable trend in cancer mortality over the past three decades, but this trend has been less favorable for most eastern European countries. While cancer mortality rates have been declining in western Europe since 1990, rates in eastern Europe only started to decline in the 2000s for men and remained stable for women. The mortality rates for lung cancer and other cancers are higher in eastern Europe compared to western Europe. Differences in lifestyle patterns and the implementation of improvements in cancer diagnosis and management contribute to the persisting disparity in cancer mortality between western and eastern Europe.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Cardiac & Cardiovascular Systems
Steven Hageman, Lisa Pennells, Francisco Ojeda, Stephen Kaptoge, Kari Kuulasmaa, Tamar de Vries, Zhe Xu, Frank Kee, Ryan Chung, Angela Wood, John William McEvoy, Giovanni Veronesi, Thomas Bolton, Paul Dendale, Brian A. Ference, Martin Halle, Adam Timmis, Panos Vardas, John Danesh, Ian Graham, Veikko Salomaa, Frank Visseren, Dirk De Bacquer, Stefan Blankenberg, Jannick Dorresteijn, Emanuele Di Angelantonio, Stephan Achenbach, Krasimira Aleksandrova, Pilar Amiano, Philippe Amouyel, Jonas Andersson, Stephan J. L. Bakker, Rui Bebiano Da Providencia Costa, Joline W. J. Beulens, Michael Blaha, Martin Bobak, Jolanda M. A. Boer, Catalina Bonet, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Tonje Braaten, Hermann Brenner, Fabian Brunner, Eric J. Brunner, Mattias Brunstrom, Julie Buring, Adam S. Butterworth, Nadezda Capkova, Giancarlo Cesana, Christina Chrysohoou, Sandra Colorado-Yohar, Nancy R. Cook, Cyrus Cooper, Christina C. Dahm, Karina Davidson, Elaine Dennison, Augusto Di Castelnuovo, Chiara Donfrancesco, Marcus Doerr, Agnieszka Dorynska, Mats Eliasson, Gunnar Engstrom, Pietro Ferrari, Marco Ferrario, Ian Ford, Michael Fu, Ron T. Gansevoort, Simona Giampaoli, Richard F. Gillum, Agustin Gomez de la Camara, Guido Grassi, Per-Olof Hansson, Radu Huculeci, Kristian Hveem, Licia Iacoviello, M. Kamran Ikram, Torben Jorgensen, Bijoy Joseph, Pekka Jousilahti, J. Wouter Jukema, Rudolf Kaaks, Verena Katzke, Maryam Kavousi, Stefan Kiechl, Jens Klotsche, Wolfgang Koenig, Richard A. Kronmal, Ruzena Kubinova, Anna Kucharska-Newton, Kristi Lall, Nils Lehmann, David Leistner, Allan Linneberg, David Lora Pablos, Thiess Lorenz, Wentian Lu, Dalia Luksiene, Magnus Lyngbakken, Christina Magnussen, Sofia Malyutina, Alejandro Marin Ibanez, Giovanna Masala, Ellisiv B. Mathiesen, Kuni Matsushita, Tom W. Meade, Olle Melander, Haakon E. Meyer, Karel G. M. Moons, Conchi Moreno-Iribas, David Muller, Thomas Muenzel, Yury Nikitin, Borge G. Nordestgaard, Torbjorn Omland, Charlotte Onland, Kim Overvad, Chris Packard, Andrzej Pajak, Luigi Palmieri, Demosthenes Panagiotakos, Salvatore Panico, Aurora Perez-Cornago, Annette Peters, Arto Pietila, Hynek Pikhart, Bruce M. Psaty, Fosca Quarti-Trevano, J. Ramon Quiros Garcia, Elio Riboli, Paul M. Ridker, Beatriz Rodriguez, Miguel Rodriguez-Barranco, Annika Rosengren, Ronan Roussel, Carlotta Sacerdote, Susana Sans, Naveed Sattar, Catarina Schiborn, Boerge Schmidt, Ben Schoettker, Matthias Schulze, Joseph E. Schwartz, Randi Marie Selmer, Steven Shea, Martin J. Shipley, Sabina Sieri, Stefan Soderberg, Reecha Sofat, Abdonas Tamosiunas, Barbara Thorand, Taavi Tillmann, Anne Tjonneland, Tammy Y. N. Tong, Antonia Trichopoulou, Rosario Tumino, Hugh Tunstall-Pedoe, Anne Tybjaerg-Hansen, Joanna Tzoulaki, Amber van der Heijden, Yvonne T. van der Schouw, W. M. Monique Verschuren, Henry Voelzke, Christoph Waldeyer, Nicholas J. Wareham, Elisabete Weiderpass, Franz Weidinger, Philipp Wild, Johann Willeit, Peter Willeit, Tom Wilsgaard, Mark Woodward, Tanja Zeller, Dudan Zhang, Bin Zhou
Summary: The study aimed to develop, validate, and demonstrate an updated prediction model (SCORE2) to estimate 10-year cardiovascular disease risk in individuals without previous history of CVD or diabetes in Europe. The new algorithm, SCORE2, enhances the identification of individuals at higher risk of developing CVD across Europe by predicting first-onset CVD risk in European populations.
EUROPEAN HEART JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Catherine Lee, Lawrence H. Kushi, Mary E. Reed, Elizabeth H. Eldridge, Jeffrey K. Lee, Jie Zhang, Donna Spiegelman
Summary: The elimination of cost sharing for colorectal cancer screening due to the Affordable Care Act was associated with a decrease in colorectal cancer incidence and mortality. Removing the financial burden from cost sharing can lead to improved colorectal cancer outcomes.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Oncology
Maximilian Marhold, Gero Kramer, Michael Krainer, Clementine Le Magnen
Summary: This short review provides an insight into the treatment landscape of prostate cancer in Europe, with a focus on improvements in care.
Article
Gastroenterology & Hepatology
Feng Guo, Dominic Edelmann, Rafael Cardoso, Xuechen Chen, Prudence R. Carr, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner
Summary: This study aimed to evaluate whether a polygenic risk score (PRS) could help define personalized and risk-adapted colorectal cancer (CRC) screening strategies. The study found significant variations in CRC risk based on the PRS, including among individuals with detection and removal of adenomas at colonoscopy. Considering genetic susceptibility, using the PRS to determine risk-adapted surveillance intervals may be helpful.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Neerav Goyal, Max Hennessy, Erik Lehman, Wenxue Lin, Antonio Agudo, Wolfgang Ahrens, Stefania Boccia, Paul Brennan, Hermann Brenner, Gabriella Cadoni, Cristina Canova, Chu Chen, David Conway, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Valeria Edefonti, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Werner Garavello, Maura Gillison, Richard B. Hayes, Claire Healy, Rolando Herrero, Ivana Holcatova, Jossy L. Kanda, Karl Kelsey, Bo T. Hansen, Rosalina Koifman, Pagona Lagiou, Carlo La Vecchia, Fabio Levi, Guojun Li, Jolanta Lissowska, Rossana Mendoza Lopez, Daniele Luce, Gary Macfarlane, Dana Mates, Keitaro Matsuo, Michael McClean, Ana Menezes, Gwenn Menvielle, Hal Morgenstern, Kirsten Moysich, Eva Negri, Andrew F. Olshan, Tamas Pandics, Jerry Polesel, Mark Purdue, Loredana Radoi, Heribert Ramroth, Lorenzo Richiardi, Stimson Schantz, Stephen M. Schwartz, Diego Serraino, Oxana Shangina, Elaine Smith, Erich M. Sturgis, Beata Swiatkowska, Peter Thomson, Thomas L. Vaughan, Marta Vilensky, Deborah M. Winn, Victor Wunsch-Filho, Guo-Pei Yu, Jose P. Zevallos, Zuo-Feng Zhang, Tongzhang Zheng, Ariana Znaor, Paolo Boffetta, Mia Hashibe, Yuan-Chin A. Lee, Joshua E. Muscat
Summary: This study analyzed the relationship between cigarette smoking, alcohol consumption, and head and neck cancer risk factors in less developed and more developed countries. The results showed that the duration of smoking and alcohol consumption had different effects on the risk of specific cancer sites depending on the country's level of development. These findings suggest that the degree of industrialization and economic development affects the relationship between smoking, alcohol, and head and neck cancer.
Article
Clinical Neurology
Leon Beyer, Hannah Stocker, Dan Rujescu, Bernd Holleczek, Julia Stockmann, Andreas Nabers, Hermann Brenner, Klaus Gerwert
Summary: This study found that certain blood-based biomarkers are associated with clinical risk of Alzheimer's disease in a long-term community cohort. A beta misfolding and GFAP concentration were particularly important and accurate predictors of AD risk.
ALZHEIMERS & DEMENTIA
(2023)
Article
Gastroenterology & Hepatology
Hongda Chen, Jufang Shi, Ming Lu, Yanjie Li, Lingbin Du, Xianzhen Liao, Donghua Wei, Dong Dong, Yi Gao, Chen Zhu, Rongbiao Ying, Weifang Zheng, Shipeng Yan, Haifan Xiao, Juan Zhang, Yunxin Kong, Furong Li, Shuangmei Zou, Chengcheng Liu, Hong Wang, Yuhan Zhang, Bin Lu, Chenyu Luo, Jie Cai, Jianbo Tian, Xiaoping Miao, Kefeng Ding, Hermann Brenner, Min Dai
Summary: This study compared the screening yield and cost of a risk-adapted screening approach with established screening strategies for population-based colorectal cancer screening. It found that the risk-adapted approach is a feasible and cost-effective strategy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Volker Arndt, Daniela Doege, Stefan Froehling, Peter Albers, Hana Alguel, Ralf Bargou, Carsten Bokemeyer, Martin Bornhaeuser, Christian H. Brandts, Peter Brossart, Sara Yvonne Brucker, Tim H. Bruemmendorf, Hartmut Doehner, Norbert Gattermann, Michael Hallek, Volker Heinemann, Ulrich Keilholz, Thomas Kindler, Cornelia von Levetzow, Florian Lordick, Ulf Peter Neumann, Christoph Peters, Dirk Schadendorf, Stephan Stilgenbauer, Thomas Zander, Daniel Zips, Delia Braun, Thomas Seufferlein, Gerd Nettekoven, Michael Baumann
Summary: The capacities of German Comprehensive Cancer Centers (CCCs) in various aspects of oncology care were significantly affected during the first 2 years of the COVID-19 pandemic. Follow-up, psycho-oncologic care, and tumor surgery were particularly impacted, along with other areas of multidisciplinary oncological care. This study highlights the importance of developing strategies to prevent similar limitations in the future.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tomotaka Ugai, Koichiro Haruki, Tabitha A. Harrison, Yin Cao, Conghui Qu, Andrew T. Chan, Peter T. Campbell, Naohiko Akimoto, Sonja Berndt, Hermann Brenner, Daniel D. Buchanan, Jenny Chang-Claude, Kenji Fujiyoshi, Steven J. Gallinger, Marc J. Gunter, Akihisa Hidaka, Michael Hoffmeister, Li Hsu, Mark A. Jenkins, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Reiko Nishihara, Rish K. Pai, Lori C. Sakoda, Martha L. Slattery, Wei Sun, Efrat L. Amitay, Elizabeth Alwers, Stephen N. Thibodeau, Amanda E. Toland, Bethany Van Guelpen, Michael O. Woods, Syed H. Zaidi, John D. Potter, Marios Giannakis, Mingyang Song, Jonathan A. Nowak, Amanda I. Phipps, Ulrike Peters, Shuji Ogino
Summary: Early-onset colorectal cancer is on the rise, and the prevalence of certain tumor molecular characteristics varies along different subsites of the colon. Understanding these differences by age and tumor location is crucial for personalized patient management.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Yu-Ru Su, Lori C. Sakoda, Jihyoun Jeon, Minta Thomas, Yi Lin, Jennifer L. Schneider, Natalia Udaltsova, Jeffrey K. Lee, Iris Lansdorp-Vogelaar, Elisabeth F. P. Peterse, Ann G. Zauber, Jiayin Zheng, Yingye Zheng, Elizabeth Hauser, John A. Baron, Elizabeth L. Barry, D. Timothy Bishop, Hermann Brenner, Daniel D. Buchanan, Andrea Burnett-Hartman, Peter T. Campbell, Graham Casey, Sergi Castellvi-Bel, Andrew T. Chan, Jenny Chang-Claude, Jane C. Figueiredo, Steven J. Gallinger, Graham G. Giles, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Jochen Hampe, Heather Hampel, Tabitha A. Harrison, Michael Hoffmeister, Xinwei Hua, Jeroen R. Huyghe, Mark A. Jenkins, Temitope O. Keku, Loic Le Marchand, Li Li, Annika Lindblom, Victor Moreno, Polly A. Newcomb, Paul D. P. Pharoah, Elizabeth A. Platz, John D. Potter, Conghui Qu, Gad Rennert, Robert E. Schoen, Martha L. Slattery, Mingyang Song, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Alicja Wolk, Michael O. Woods, Anna H. Wu, Richard B. Hayes, Ulrike Peters, Douglas A. Corley, Li Hsu
Summary: This study externally validated a polygenic risk score (PRS)-enhanced colorectal cancer risk model comprising 140 known colorectal cancer loci. The results showed that the PRS improved the prediction and discrimination of colorectal cancer risk, suggesting its potential utility in risk-stratified colorectal cancer prevention.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Genetics & Heredity
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Bien, Virginia Diez-Obrero, Li Li, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Harris, Victoria Svinti, Kevin McDonnell, Susan Farrington, James Studd, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Scacheri, James Studd, Jeroen Huyghe, Tabitha Harrison, David Shibata, Christopher Haiman, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obon-Santacana, Vicente Martin-Sanchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Potter, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Shibata, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Boehm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hanninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Mannisto, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Shibata, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Gruber, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stephane Bezieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters
Summary: This study identified 205 independent risk associations for colorectal cancer through a genome-wide association study meta-analysis. Transcriptome and methylome analysis further revealed 53 risk associations. These findings provide insights into the genetic and molecular mechanisms of colorectal oncogenesis and suggest potential targets for new treatment and prevention strategies.
Article
Computer Science, Artificial Intelligence
Zhe Liu
Summary: Multi-sensor data fusion is important for integrating information efficiently, but the collected information may be uncertain and conflicting. This paper proposes a novel belief Sorensen coefficient (BSC) to quantify the conflict of evidence based on belief functions theory (BFT). The BSC is further used to design a new multi-sensor data fusion method, which is demonstrated to be effective and practical through numerical examples and application cases.
ARTIFICIAL INTELLIGENCE REVIEW
(2023)
Article
Oncology
Ben Schoettker, Li-Ju Chen, Reiner Caspari, Hermann Brenner
Summary: The aim of this study is to improve the quality of life in older cancer patients through a medication review using the FORTA list. A total of 514 cancer patients aged 65 and above will be recruited in German rehabilitation clinics. The primary outcome will be assessed with self-administered questionnaires 8 months after baseline.
Article
Oncology
Elom K. Aglago, Andre Kim, Yi Lin, Conghui Qu, Marina Evangelou, Yu Ren, John Morrison, Demetrius Albanes, Volker Arndt, Elizabeth L. Barry, James W. Baurley, Sonja Berndt, Stephanie A. Bien, D. Timothy Bishop, Emmanouil Bouras, Hermann Brenner, Daniel D. Buchanan, Ari Budiarto, Robert Carreras-Torres, Graham Casey, Tjeng Wawan Cenggoro, Andrew T. Chen, Jenny Chang-Claude, Xuechen Chen, David Conti, Matthew Devall, Virginia Diez-Obrero, Niki Dimou, David Drew, Jane C. Figueiredo, Steven Gallinger, Graham G. Giles, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Heather Hampel, Sophia Harlid, Akihisa Hidaka, Tabitha A. Harrison, Michael Hoffmeister, Jeroen R. Huyghe, Mark A. Jenkins, Kristina Jordahl, Amit D. Joshi, Eric S. Kawaguchi, Temitope O. Keku, Anshul Kundaje, Susanna C. Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Brigid M. Lynch, Bharuno Mahesworo, Marko Mandic, Mireia Obon-Santacana, Victor Morento, Neil Murphy, Hongmei Men, Rami Nassir, Polly A. Newcomb, Shuji Ogino, Jennifer Ose, Rish K. Pai, Julie R. Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R. Peoples, Elizabeth A. Platz, John D. Potter, Ross L. Prentice, Gad Rennert, Edward Ruiz-Narvaez, Lori C. Sakoda, Peter C. Scacheri, Stephanie L. Schmit, Robert E. Schoen, Anna Shcherbina, Martha L. Slattery, Mariana C. Stern, Yu-Ru Su, Catherine M. Tangen, Stephen N. Thibodeau, Duncan C. Thomas, Yu Tian, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Kala Visvanathan, Pavel Vodicka, Jun Wang, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Natalia Zemlianskaia, Li Hsu, W. James Gauderman, Ulrike Peters, Konstantinos K. Tsilidis, Peter T. Campbell
Summary: Colorectal cancer risk is influenced by genetic, environmental, and lifestyle factors. This study identified a gene-environment interaction between body mass index (BMI) and a specific gene that increases the risk of colorectal cancer.
Article
Oncology
Bouchra Tawk, Katrin Rein, Christian Schwager, Maximilian Knoll, Ute Wirkner, Juliane Hoerner-Rieber, Jakob Liermann, Ina Kurth, Panagiotis Balermpas, Claus Roedel, Annett Linge, Steffen Loeck, Fabian Lohaus, Ingeborg Tinhofer, Mechtild Krause, Martin Stuschke, Anca Ligia Grosu, Daniel Zips, Stephanie E. Combs, Claus Belka, Albrecht Stenzinger, Christel Herold-Mende, Michael Baumann, Peter Schirmacher, Jurgen Debus, Amir Abdollahi
Summary: This study suggests that the DNA methylation landscape of tumor cells may indicate epigenetic changes caused by chronic tumor hypoxia. The researchers developed a tumor hypoxia classifier (Hypoxia-M) based on DNA methylation profiles, which showed independent prognostic effects in patients with head and neck squamous cell carcinoma (HNSCC). These findings underscore the importance of DNA methylation-based classifiers as biomarkers of tumor hypoxia.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Ekaterina Nikitina, Amelie Burk-Koerner, Manuel Wiesenfarth, Elizabeth Alwers, Danijela Heide, Claudia Tessmer, Claudia Ernst, Damir Krunic, Petra Schrotz-King, Jenny Chang-Claude, Moritz von Winterfeld, Esther Herpel, Alexander Brobeil, Hermann Brenner, Mathias Heikenwalder, Michael Hoffmeister, Annette Kopp-Schneider, Timo Bund
Summary: This study assessed the expression of bovine milk and meat factors (BMMFs) in large clinical cohorts and found that BMMFs were associated with tumor-adjacent mucosa and tumor tissues of colorectal cancer (CRC) patients, with increased expression in CRC patients compared to healthy controls. The expression of BMMFs might be a marker and early risk factor for CRC, and could be involved in specific inflammatory regulations.
MOLECULAR ONCOLOGY
(2023)
Article
Clinical Neurology
Hannah Stocker, Kira Trares, Leon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Klaus Gerwert, Ben Schoettker, Hermann Brenner
Summary: This study examines the association between the APOE4 gene and polygenic risk scores (PRS) for Alzheimer's disease (AD). It found that PRSs are more accurate in assessing the risk of cognitive impairment in APOE4 carriers. Additionally, the study finds a significant association between APOE4 and GFAP levels.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Geriatrics & Gerontology
Friederike Hildegard Boehlen, Dirk Heider, Dieter Schellberg, Johanna Katharina Hohls, Ben Schoettker, Hermann Brenner, Hans-Christoph Friederich, Hans-Helmut Koenig, Beate Wild
Summary: This article investigates the gender differences in the association between loneliness and health care use in a large sample of community-dwelling older adults. The study found that lonely older women had significantly more visits to general practitioners and mental health care providers, while older men had more contact with inpatient care.
