A Novel System for Simultaneous or Sequential Integration of Multiple Gene-Loading Vectors into a Defined Site of a Human Artificial Chromosome

Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors

(2014) Jonah Riddell et al.   CELL

Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming

(2014) Yuanyuan Du et al.   Cell Stem Cell

Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology

(2014) Natalay Kouprina et al.   Expert Opinion on Drug Delivery

Novel Method to Load Multiple Genes onto a Mammalian Artificial Chromosome

(2014) Anna Tóth et al.   PLoS One

Bi-HAC Vector System toward Gene and Cell Therapy

(2014) Yuichi Iida et al.   ACS Synthetic Biology

A novel mouse model for Down syndrome that harbor a single copy of human artificial chromosome (HAC) carrying a limited number of genes from human chromosome 21

(2013) Kenichi Miyamoto et al.   TRANSGENIC RESEARCH

Organization of Synthetic Alphoid DNA Array in Human Artificial Chromosome (HAC) with a Conditional Centromere

(2012) Natalay Kouprina et al.   ACS Synthetic Biology

A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells

(2011) Minoru Kakeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx2

(2011) K. Kitajima et al.   BLOOD

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

(2011) Esther Y. Son et al.   Cell Stem Cell

Integration-free and stable expression of FVIII using a human artificial chromosome

(2011) Hajime Kurosaki et al.   JOURNAL OF HUMAN GENETICS

A Method for Producing Transgenic Cells Using a Multi-Integrase System on a Human Artificial Chromosome Vector

(2011) Shigeyuki Yamaguchi et al.   PLoS One

Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors

(2011) Masaharu Hiratsuka et al.   PLoS One

Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells

(2011) J.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression

(2010) Y. Iida et al.   DNA RESEARCH

Refined human artificial chromosome vectors for gene therapy and animal transgenesis

(2010) Y Kazuki et al.   GENE THERAPY

Serine recombinases as tools for genome engineering

(2010) William R.A. Brown et al.   METHODS

Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy

(2009) Yasuhiro Kazuki et al.   MOLECULAR THERAPY

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

(2008) Megumi Nakano et al.   DEVELOPMENTAL CELL

A highly Stable and Nonintegrated Human Artificial Chromosome (HAC) Containing the 2.4 Mb Entire Human Dystrophin Gene

(2008) Hidetoshi Hoshiya et al.   MOLECULAR THERAPY