Luteolin Suppresses Cancer Cell Proliferation by Targeting Vaccinia-Related Kinase 1

Comparative Studies to Evaluate Relative in vitro Potency of Luteolin in Inducing Cell Cycle Arrest and Apoptosis in HaCaT and A375 Cells

(2013) Vazhapilly Cijo George et al.   Asian Pacific Journal of Cancer Prevention

Vaccinia-Related Kinase 2 Mediates Accumulation of Polyglutamine Aggregates via Negative Regulation of the Chaperonin TRiC

(2013) S. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Chemopreventive and Therapeutic Potential of Tea Polyphenols in Hepatocellular Cancer

(2013) Altaf S. Darvesh et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas

(2013) Il-Jin Kim et al.   Nature Communications

Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo

(2013) T P Molitor et al.   Oncogenesis

Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities

(2012) Chia-Jui Weng et al.   CANCER AND METASTASIS REVIEWS

Killing cells by targeting mitosis

(2012) E Manchado et al.   CELL DEATH AND DIFFERENTIATION

The dietary flavonoid luteolin inhibits Aurora B kinase activity and blocks proliferation of cancer cells

(2012) Fang Xie et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Vaccinia-related Kinase 1 (VRK1) Is an Upstream Nucleosomal Kinase Required for the Assembly of 53BP1 Foci in Response to Ionizing Radiation-induced DNA Damage

(2012) Marta Sanz-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitogen-activated protein kinase phosphatase 2 regulates histone H3 phosphorylation via interaction with vaccinia-related kinase 1

(2012) Min-Woo Jeong et al.   MOLECULAR BIOLOGY OF THE CELL

HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence

(2012) Yoon Ha Choi et al.   NUCLEIC ACIDS RESEARCH

Mitosis-targeted anti-cancer therapies: where they stand

(2012) K-S Chan et al.   Cell Death & Disease

Effects of dietary flavonoids, luteolin, and quercetin on the reversal of epithelial-mesenchymal transition in A431 epidermal cancer cells

(2011) Yung-Sheng Lin et al.   CANCER SCIENCE

Roles of VRK1 as a new player in the control of biological processes required for cell division

(2011) Alberto Valbuena et al.   CELLULAR SIGNALLING

NMR Solution Structure of Human Vaccinia-related Kinase 1 (VRK1) Reveals the C-terminal Tail Essential for Its Structural Stability and Autocatalytic Activity

(2011) Joon Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macro Histone H2A1.2 (MacroH2A1) Protein Suppresses Mitotic Kinase VRK1 during Interphase

(2011) Wanil Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cell cycle and cancer

(2011) Gareth H Williams et al.   JOURNAL OF PATHOLOGY

Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage–induced apoptosis

(2011) Choon-Ho Park et al.   MOLECULAR BIOLOGY OF THE CELL

Anti-carcinogenic Effects of the Flavonoid Luteolin

(2011) Günter Seelinger et al.   MOLECULES

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2

(2011) Marta Vázquez-Cedeira et al.   PLoS One

Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells

(2011) Xueting Cai et al.   TOXICOLOGY IN VITRO

Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt–GSK-3β–Cyclin D1 pathway

(2010) Chye-Sun Ong et al.   CANCER LETTERS

Luteolin Inhibits Protein Kinase C  and c-Src Activities and UVB-Induced Skin Cancer

(2010) S. Byun et al.   CANCER RESEARCH

Vaccinia-Related Kinase 1 Is Required for the Maintenance of Undifferentiated Spermatogonia in Mouse Male Germ Cells

(2010) Yoon Ha Choi et al.   PLoS One

Distribution and Biological Activities of the Flavonoid Luteolin

(2009) Miguel Lopez-Lazaro   MINI-REVIEWS IN MEDICINAL CHEMISTRY

DNA Damage Detection and Repair Pathways--Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy

(2008) S. Ashwell et al.   CLINICAL CANCER RESEARCH

Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy

(2008) Yong Lin et al.   CURRENT CANCER DRUG TARGETS

Emerging cancer therapeutic opportunities by inhibiting mitotic kinases

(2008) Ignacio Pérez de Castro et al.   CURRENT OPINION IN PHARMACOLOGY

VRK1 phosphorylates CREB and mediates CCND1 expression

(2008) T.-H. Kang et al.   JOURNAL OF CELL SCIENCE

Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly

(2008) T. Haraguchi et al.   JOURNAL OF CELL SCIENCE

Plk3 Interacts with and Specifically Phosphorylates VRK1 in Ser342, a Downstream Target in a Pathway That Induces Golgi Fragmentation

(2008) I. Lopez-Sanchez et al.   MOLECULAR AND CELLULAR BIOLOGY

Anti-Oxidant, Anti-Inflammatory and Anti-Allergic Activities of Luteolin

(2008) Günter Seelinger et al.   PLANTA MEDICA

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression

(2008) Alberto Valbuena et al.   PLoS One

Prognostic Breast Cancer Signature Identified from 3D Culture Model Accurately Predicts Clinical Outcome across Independent Datasets

(2008) Katherine J. Martin et al.   PLoS One