Quantification of Heterogeneity as a Biomarker in Tumor Imaging: A Systematic Review
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Title
Quantification of Heterogeneity as a Biomarker in Tumor Imaging: A Systematic Review
Authors
Keywords
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Journal
PLoS One
Volume 9, Issue 10, Pages e110300
Publisher
Public Library of Science (PLoS)
Online
2014-10-21
DOI
10.1371/journal.pone.0110300
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Note: Only part of the references are listed.- Digital Image Analysis Is a Useful Adjunct to Endoscopic Ultrasonographic Diagnosis of Subepithelial Lesions of the Gastrointestinal Tract
- (2017) Vien X. Nguyen et al. JOURNAL OF ULTRASOUND IN MEDICINE
- Quantitative Measurement for Thyroid Cancer Characterization Based on Elastography
- (2017) Jianrui Ding et al. JOURNAL OF ULTRASOUND IN MEDICINE
- Conventional Frequency Ultrasonic Biomarkers of Cancer Treatment Response In Vivo
- (2014) Ali Sadeghi-Naini et al. Translational Oncology
- Relationship Between Imaging Biomarkers of Stage I Cervical Cancer and Poor-Prognosis Histologic Features: Quantitative Histogram Analysis of Diffusion-Weighted MR Images
- (2013) Kate Downey et al. AMERICAN JOURNAL OF ROENTGENOLOGY
- Shearlet-based texture feature extraction for classification of breast tumor in ultrasound image
- (2013) Shichong Zhou et al. Biomedical Signal Processing and Control
- Cancer heterogeneity: implications for targeted therapeutics
- (2013) R Fisher et al. BRITISH JOURNAL OF CANCER
- Tumor Heterogeneity and Permeability as Measured on the CT Component of PET/CT Predict Survival in Patients with Non-Small Cell Lung Cancer
- (2013) T. Win et al. CLINICAL CANCER RESEARCH
- Comparative evaluation of support vector machines for computer aided diagnosis of lung cancer in CT based on a multi-dimensional data set
- (2013) Tao Sun et al. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
- Robustness of intratumour 18F-FDG PET uptake heterogeneity quantification for therapy response prediction in oesophageal carcinoma
- (2013) Mathieu Hatt et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Texture analysis of advanced non-small cell lung cancer (NSCLC) on contrast-enhanced computed tomography: prediction of the response to the first-line chemotherapy
- (2013) Marco Ravanelli et al. EUROPEAN RADIOLOGY
- Combination of Radiological and Gray Level Co-occurrence Matrix Textural Features Used to Distinguish Solitary Pulmonary Nodules by Computed Tomography
- (2013) Haifeng Wu et al. JOURNAL OF DIGITAL IMAGING
- Quantitative assessment Ki-67 score for prediction of response to neoadjuvant chemotherapy in breast cancer
- (2013) Jason R Brown et al. LABORATORY INVESTIGATION
- Texture-based and diffusion-weighted discrimination of parotid gland lesions on MR images at 3.0 Tesla
- (2013) Julia Fruehwald-Pallamar et al. NMR IN BIOMEDICINE
- Automatic texture-based analysis in ultrasound imaging of ovarian masses
- (2013) F Faschingbauer et al. ULTRASCHALL IN DER MEDIZIN
- Computer-Aided Diagnosis for 3-D Power Doppler Breast Ultrasound
- (2013) Yi-Chen Lai et al. ULTRASOUND IN MEDICINE AND BIOLOGY
- Does volume perfusion computed tomography enable differentiation of metastatic and non-metastatic mediastinal lymph nodes in lung cancer patients? A feasibility study
- (2013) Daniel Spira et al. CANCER IMAGING
- Multimodality GPU-based computer-assisted diagnosis of breast cancer using ultrasound and digital mammography images
- (2013) Konstantinos P. Sidiropoulos et al. International Journal of Computer Assisted Radiology and Surgery
- Evaluation of Hepatic Tumor Response to Yttrium-90 Radioembolization Therapy Using Texture Signatures Generated from Contrast-enhanced CT Images
- (2012) Rebekah H. Gensure et al. ACADEMIC RADIOLOGY
- Distinguishing radiation fibrosis from tumour recurrence after stereotactic ablative radiotherapy (SABR) for lung cancer: A quantitative analysis of CT density changes
- (2012) Sarah A. Mattonen et al. ACTA ONCOLOGICA
- Diffusion-Weighted Imaging of Breast Masses: Comparison of Diagnostic Performance Using Various Apparent Diffusion Coefficient Parameters
- (2012) Maki Hirano et al. AMERICAN JOURNAL OF ROENTGENOLOGY
- Nasopharyngeal Carcinoma: Investigation of Intratumoral Heterogeneity With FDG PET/CT
- (2012) Bingsheng Huang et al. AMERICAN JOURNAL OF ROENTGENOLOGY
- A computer-aided algorithm to quantitatively predict lymph node status on MRI in rectal cancer
- (2012) D M L Tse et al. BRITISH JOURNAL OF RADIOLOGY
- Characterizing the major sonographic textural difference between metastatic and common benign lymph nodes using support vector machine with histopathologic correlation
- (2012) Shao-Jer Chen et al. CLINICAL IMAGING
- Computerized Segmentation and Characterization of Breast Lesions in Dynamic Contrast-Enhanced MR Images Using Fuzzy c-Means Clustering and Snake Algorithm
- (2012) Yachun Pang et al. Computational and Mathematical Methods in Medicine
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- (2012) Delia Mitrea et al. Computational and Mathematical Methods in Medicine
- Combining support vector machine with genetic algorithm to classify ultrasound breast tumor images
- (2012) Wen-Jie Wu et al. COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
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- (2012) JV Raja et al. DENTOMAXILLOFACIAL RADIOLOGY
- Quantifying heterogeneity in human tumours using MRI and PET
- (2012) Marie-Claude Asselin et al. EUROPEAN JOURNAL OF CANCER
- Assessment of tumor heterogeneity by CT texture analysis: Can the largest cross-sectional area be used as an alternative to whole tumor analysis?
- (2012) Francesca Ng et al. EUROPEAN JOURNAL OF RADIOLOGY
- Breast cancer intratumor genetic heterogeneity: causes and implications
- (2012) Charlotte KY Ng et al. Expert Review of Anticancer Therapy
- Analysis of Co-Occurrence Texture Statistics as a Function of Gray-Level Quantization for Classifying Breast Ultrasound
- (2012) W. Gomez et al. IEEE TRANSACTIONS ON MEDICAL IMAGING
- A dual neural network ensemble approach for multiclass brain tumor classification
- (2012) Jainy Sachdeva et al. International Journal for Numerical Methods in Biomedical Engineering
- Spatial-Temporal [18F]FDG-PET Features for Predicting Pathologic Response of Esophageal Cancer to Neoadjuvant Chemoradiation Therapy
- (2012) Shan Tan et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- SVM-Based Characterization of Liver Ultrasound Images Using Wavelet Packet Texture Descriptors
- (2012) Jitendra Virmani et al. JOURNAL OF DIGITAL IMAGING
- Feature Selection in Computer-Aided Breast Cancer Diagnosis via Dynamic Contrast-Enhanced Magnetic Resonance Images
- (2012) Megan Rakoczy et al. JOURNAL OF DIGITAL IMAGING
- Unknown
- (2012) Mahesh B. Nagarajan Journal of Medical and Biological Engineering
- Computer Aided Diagnosis System for Breast Cancer Based on Color Doppler Flow Imaging
- (2012) Yan Liu et al. JOURNAL OF MEDICAL SYSTEMS
- Measurements of heterogeneity in gliomas on computed tomography relationship to tumour grade
- (2012) Karoline Skogen et al. JOURNAL OF NEURO-ONCOLOGY
- Are Pretreatment 18F-FDG PET Tumor Textural Features in Non-Small Cell Lung Cancer Associated with Response and Survival After Chemoradiotherapy?
- (2012) G. J. R. Cook et al. JOURNAL OF NUCLEAR MEDICINE
- Microcirculatory fraction (MCFI) as a potential imaging marker for tumor heterogeneity in breast cancer
- (2012) Xiangyu Yang et al. MAGNETIC RESONANCE IMAGING
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- (2012) Marco Dominietto et al. MAGNETIC RESONANCE IN MEDICINE
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- (2012) K. Yan et al. MEDICAL PHYSICS
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- (2012) Shin-Lei Peng et al. NMR IN BIOMEDICINE
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- (2012) Xinzhe Dong et al. NUCLEAR MEDICINE COMMUNICATIONS
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- (2012) J M Y Willaime et al. PHYSICS IN MEDICINE AND BIOLOGY
- Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
- (2012) N. J. Szerlip et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2011) N. Dumrongpisutikul et al. AMERICAN JOURNAL OF NEURORADIOLOGY
- Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment
- (2011) Peter A Fasching et al. BMC CANCER
- DCE-MRI biomarkers of tumour heterogeneity predict CRC liver metastasis shrinkage following bevacizumab and FOLFOX-6
- (2011) J P B O'Connor et al. BRITISH JOURNAL OF CANCER
- Optical Differentiation Between Malignant and Benign Lymphadenopathy by Grey Scale Texture Analysis of Endobronchial Ultrasound Convex Probe Images
- (2011) Phan Nguyen et al. CHEST
- Tumour heterogeneity in oesophageal cancer assessed by CT texture analysis: Preliminary evidence of an association with tumour metabolism, stage, and survival
- (2011) B. Ganeshan et al. CLINICAL RADIOLOGY
- ThyroScreen system: High resolution ultrasound thyroid image characterization into benign and malignant classes using novel combination of texture and discrete wavelet transform
- (2011) U. Rajendra Acharya et al. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
- Neural network based focal liver lesion diagnosis using ultrasound images
- (2011) Deepti Mittal et al. COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
- Computer-aided diagnosis in breast DCE-MRI—Quantification of the heterogeneity of breast lesions
- (2011) Uta Preim et al. EUROPEAN JOURNAL OF RADIOLOGY
- Quantitative analysis and prediction of regional lymph node status in rectal cancer based on computed tomography imaging
- (2011) Chunyan Cui et al. EUROPEAN RADIOLOGY
- Tumour heterogeneity in non-small cell lung carcinoma assessed by CT texture analysis: a potential marker of survival
- (2011) Balaji Ganeshan et al. EUROPEAN RADIOLOGY
- A Statistical Modeling Approach to the Analysis of Spatial Patterns of FDG-PET Uptake in Human Sarcoma
- (2011) F. O'Sullivan et al. IEEE TRANSACTIONS ON MEDICAL IMAGING
- Tumor Metabolism and Perfusion in Head and Neck Squamous Cell Carcinoma: Pretreatment Multimodality Imaging With 1H Magnetic Resonance Spectroscopy, Dynamic Contrast-Enhanced MRI, and [18F]FDG-PET
- (2011) Jacobus F.A. Jansen et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Quantifying Tumor Vascular Heterogeneity with Dynamic Contrast-Enhanced Magnetic Resonance Imaging: A Review
- (2011) Xiangyu Yang et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Early (72-Hour) detection of radiotherapy-induced changes in an experimental tumor model using diffusion-weighted imaging, diffusion tensor imaging, and Q-space imaging parameters: A comparative study
- (2011) Frank Peeters et al. JOURNAL OF MAGNETIC RESONANCE IMAGING
- Unknown
- (2011) Yi-hui Liu Journal of Medical and Biological Engineering
- Multiparametric magnetic resonance imaging to differentiate high-grade gliomas and brain metastases
- (2011) Nathalie Mouthuy et al. JOURNAL OF NEURORADIOLOGY
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- (2011) F. Tixier et al. JOURNAL OF NUCLEAR MEDICINE
- Identification of residual metabolic-active areas within NSCLC tumours using a pre-radiotherapy FDG-PET-CT scan: A prospective validation
- (2011) Hugo J.W.L. Aerts et al. LUNG CANCER
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- (2011) Pantelis Georgiadis et al. MAGNETIC RESONANCE IMAGING
- Classification of scattering media within benign and malignant breast tumors based on ultrasound texture-feature-based and Nakagami-parameter images
- (2011) Yin-Yin Liao et al. MEDICAL PHYSICS
- Assessment of Response to Tyrosine Kinase Inhibitors in Metastatic Renal Cell Cancer: CT Texture as a Predictive Biomarker
- (2011) Vicky Goh et al. RADIOLOGY
- Combined PET/CT image characteristics for radiotherapy tumor response in lung cancer
- (2011) Manushka Vaidya et al. RADIOTHERAPY AND ONCOLOGY
- Computer-Aided Diagnosis for the Classification of Breast Masses in Automated Whole Breast Ultrasound Images
- (2011) Woo Kyung Moon et al. ULTRASOUND IN MEDICINE AND BIOLOGY
- Texture analysis of non-small cell lung cancer on unenhanced computed tomography: initial evidence for a relationship with tumour glucose metabolism and stage
- (2011) Balaji Ganeshan et al. CANCER IMAGING
- Volume and attenuation computed tomography measurements for interim evaluation of Hodgkin and follicular lymphoma as an additional surrogate parameter for more confident response monitoring: a pilot study
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- (2010) J.H. Ma et al. AMERICAN JOURNAL OF NEURORADIOLOGY
- Fusion of fuzzy statistical distributions for classification of thyroid ultrasound patterns
- (2010) Dimitris K. Iakovidis et al. ARTIFICIAL INTELLIGENCE IN MEDICINE
- LEARNING PATTERNS OF LIVER MASSES USING IMPROVED RBF NETWORKS
- (2010) Chien-Cheng Lee et al. Biomedical Engineering - Applications, Basis and Communications
- Assessing heterogeneity of lesion enhancement kinetics in dynamic contrast-enhanced MRI for breast cancer diagnosis
- (2010) A Karahaliou et al. BRITISH JOURNAL OF RADIOLOGY
- Computer-aided diagnosis with textural features for breast lesions in sonograms
- (2010) Dar-Ren Chen et al. COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
- Machine learning study of several classifiers trained with texture analysis features to differentiate benign from malignant soft-tissue tumors in T1-MRI images
- (2010) Jaber Juntu et al. JOURNAL OF MAGNETIC RESONANCE IMAGING
- Texture-based classification of focal liver lesions on MRI at 3.0 Tesla: A feasibility study in cysts and hemangiomas
- (2010) Marius E. Mayerhoefer et al. JOURNAL OF MAGNETIC RESONANCE IMAGING
- Monitoring Response to Antiangiogenic Therapy in Non-Small Cell Lung Cancer Using Imaging Markers Derived from PET and Dynamic Contrast-Enhanced MRI
- (2010) A. J. de Langen et al. JOURNAL OF NUCLEAR MEDICINE
- Monitoring the Longitudinal Intra-tumor Physiological Impulse Response to VEGFR2 Blockade in Breast Tumors Using DCE-CT
- (2010) Keith M. Stantz et al. MOLECULAR IMAGING AND BIOLOGY
- The ESTRO Breur Lecture 2009. From population to voxel-based radiotherapy: Exploiting intra-tumour and intra-organ heterogeneity for advanced treatment of non-small cell lung cancer
- (2010) Philippe Lambin et al. RADIOTHERAPY AND ONCOLOGY
- Computer Aided Diagnosis of Parotid Gland Lesions Using Ultrasonic Multi-Feature Tissue Characterization
- (2010) Stefan Siebers et al. ULTRASOUND IN MEDICINE AND BIOLOGY
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- (2010) Shao-Jer Chen et al. ULTRASOUND IN MEDICINE AND BIOLOGY
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- (2009) Christine E. McLaren et al. ACADEMIC RADIOLOGY
- Characterization of Breast Cancer Types by Texture Analysis of Magnetic Resonance Images
- (2009) Kirsi Holli et al. ACADEMIC RADIOLOGY
- Inhibition of tyrosine kinase receptors by SU6668 promotes abnormal stromal development at the periphery of carcinomas
- (2009) P Farace et al. BRITISH JOURNAL OF CANCER
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- (2009) Huan Wang et al. EUROPEAN JOURNAL OF RADIOLOGY
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