Novel PDE4 Inhibitors Derived from Chinese Medicine Forsythia

Discovery of novel PDE10 inhibitors by a robust homogeneous screening assay

(2013) Qun-yi Li et al.   ACTA PHARMACOLOGICA SINICA

Phosphodiesterase-4 Inhibitor Therapy for Lung Diseases

(2013) Bianca Beghè et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation

(2013) R. K. Mallampalli et al.   JOURNAL OF IMMUNOLOGY

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation

(2013) Bill B Chen et al.   NATURE IMMUNOLOGY

Phosphodiesterase 4B Mediates Extracellular Signal-regulated Kinase-dependent Up-regulation of Mucin MUC5AC Protein byStreptococcus pneumoniaeby Inhibiting cAMP-protein Kinase A-dependent MKP-1 Phosphatase Pathway

(2012) Jiyun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZINCPharmer: pharmacophore search of the ZINC database

(2012) D. R. Koes et al.   NUCLEIC ACIDS RESEARCH

Innate Immune Response of Human Alveolar Macrophages during Influenza A Infection

(2012) Jieru Wang et al.   PLoS One

Improvement of exercise capacity in monocrotaline-induced pulmonary hypertension by the phosphodiesterase-5 inhibitor Vardenafil

(2012) Stephan Schroll et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Viral pneumonia

(2011) Olli Ruuskanen et al.   LANCET

The influence of infection sites on development and mortality of ARDS

(2010) Chau-Chyun Sheu et al.   INTENSIVE CARE MEDICINE

Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

(2009) A. L. Hertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative Relaxing Effects of Sildenafil, Vardenafil, and Tadalafil in Human Corpus Cavernosum: Contribution of Endogenous Nitric Oxide Release

(2009) Haroldo A. Toque et al.   UROLOGY

Cyclic AMP

(2008) Carlos H. Serezani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lignans from the fruits of Forsythia suspensa

(2008) Xiang-Lan Piao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lignans from the Fruits ofForsythia suspensa(Thunb.) Vahl Protect High-Density Lipoprotein during Oxidative Stress

(2008) Min-Jung CHANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Insights into the regulation of TNF-a production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition

(2008) Jessica Deree et al.   Clinics

Phosphodiesterase 5 inhibition in essential hypertension

(2008) Lorenzo Ghiadoni et al.   CURRENT HYPERTENSION REPORTS

Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated fromForsythia suspensa

(2008) Huanhuan Qu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats

(2008) Neuza Mariko Aymoto Hassimotto et al.   NUTRITION RESEARCH