Evodiamine Induces G2/M Arrest and Apoptosis via Mitochondrial and Endoplasmic Reticulum Pathways in H446 and H1688 Human Small-Cell Lung Cancer Cells

The Clonal Evolution and Therapeutic Approaches of Lung Cancer

(2014) Haixiang Yu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Evodiamine Induces Apoptosis and Enhances TRAIL-Induced Apoptosis in Human Bladder Cancer Cells through mTOR/S6K1-Mediated Downregulation of Mcl-1

(2014) Tao Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A MicroRNA Signature Predicts Survival in Early Stage Small-Cell Lung Cancer Treated with Surgery and Adjuvant Chemotherapy

(2014) Nan Bi et al.   PLoS One

LL-202, a newly synthesized flavonoid, inhibits tumor growth via inducing G2/M phase arrest and cell apoptosis in MCF-7 human breast cancer cells in vitro and in vivo

(2014) Lei Tao et al.   TOXICOLOGY LETTERS

Propofol induces endoplasmic reticulum (ER) stress and apoptosis in lung cancer cell H460

(2014) Wen-Yao Cui et al.   TUMOR BIOLOGY

20(S)-Protopanaxadiol Triggers Mitochondrial-Mediated Apoptosis in Human Lung Adenocarcinoma A549 Cells via Inhibiting the PI3K/Akt Signaling Pathway

(2013) Yun-Long Zhang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca2+-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells

(2013) A-Young Choi et al.   APOPTOSIS

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

(2013) Michael S. Christodoulou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Evaluation of a curcumin analog as an anti-cancer agent inducing ER stress-mediated apoptosis in non-small cell lung cancer cells

(2013) Zhiguo Liu et al.   BMC CANCER

Induction of the Endoplasmic Reticulum Stress and Autophagy in Human Lung Carcinoma A549 Cells by Anacardic Acid

(2013) Yeong-Ae Seong et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells

(2013) Ann-Jeng Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway

(2013) Yongli Wei et al.   FOOD AND CHEMICAL TOXICOLOGY

The chalcone 2′-hydroxy-4′,5′-dimethoxychalcone activates death receptor 5 pathway and leads to apoptosis in human nonsmall cell lung cancer cells

(2013) Lina Yang et al.   IUBMB LIFE

An Oxygen-Chelate Complex, Palladium Bis-acetylacetonate, Induces Apoptosis in H460 Cells via Endoplasmic Reticulum Stress Pathway Rather than Interacting with DNA

(2013) Yi Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane Localized Iridium(III) Complex Induces Endoplasmic Reticulum Stress and Mitochondria-Mediated Apoptosis in Human Cancer Cells

(2013) Rui Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Evaluation of N13-Substituted Evodiamine Derivatives against Human Cancer Cell Lines

(2013) Senchuan Song et al.   MOLECULES

Furanodiene Presents Synergistic Anti-proliferative Activity With Paclitaxel Via Altering Cell Cycle and Integrin Signaling in 95-D Lung Cancer Cells

(2013) Wen-Shan Xu et al.   PHYTOTHERAPY RESEARCH

A Synthetic Podophyllotoxin Derivative Exerts Anti-Cancer Effects by Inducing Mitotic Arrest and Pro-Apoptotic ER Stress in Lung Cancer Preclinical Models

(2013) Jia-Yang Chen et al.   PLoS One

Piperine induces apoptosis of lung cancer A549 cells via p53-dependent mitochondrial signaling pathway

(2013) Yi Lin et al.   TUMOR BIOLOGY

Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway

(2013) C Lv et al.   Cell Death & Disease

Design and Evaluation of a Novel Evodiamine-Phospholipid Complex for Improved Oral Bioavailability

(2012) Qunyou Tan et al.   AAPS PHARMSCITECH

Pharmacological targeting of endoplasmic reticulum stress signaling in cancer

(2012) Axel H. Schönthal   BIOCHEMICAL PHARMACOLOGY

Alkylphenols from the Roots of Ardisia brevicaulis Induce G1 Arrest and Apoptosis through Endoplasmic Reticulum Stress Pathway in Human Non-small-cell Lung Cancer Cells

(2012) Guo-Yuan Zhu et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits growth of human lung cancer A549 cells by arresting cell cycle and triggering apoptosis

(2012) Li Li et al.   Chinese Journal of Cancer Research

Enhanced Antitumor Efficacy of Gemcitabine by Evodiamine on Pancreatic Cancer via Regulating PI3K/Akt Pathway

(2012) Wei-Tian Wei et al.   International Journal of Biological Sciences

New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations

(2012) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes

(2012) Fang Xiao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Curcumin Induces Small Cell Lung Cancer NCI-H446 Cell Apoptosis via the Reactive Oxygen Species-Mediated Mitochondrial Pathway and Not the Cell Death Receptor Pathway

(2011) Cheng-Liang Yang et al.   DNA AND CELL BIOLOGY

Targeting apoptosis pathways in cancer by Chinese medicine

(2010) Min Li-Weber   CANCER LETTERS

Evodiamine: A Novel Anti-Cancer Alkaloid from Evodia rutaecarpa

(2009) Junlin Jiang et al.   MOLECULES

Cytotoxicity and Proteomics Analyses of OSU03013 in Lung Cancer

(2008) Y.-H. Tan et al.   CLINICAL CANCER RESEARCH

Erlotinib Induces Mitochondrial-Mediated Apoptosis in Human H3255 Non-Small-Cell Lung Cancer Cells with Epidermal Growth Factor ReceptorL858R Mutation through Mitochondrial Oxidative Phosphorylation-Dependent Activation of BAX and BAK

(2008) Y.-H. Ling et al.   MOLECULAR PHARMACOLOGY