Amino Alcohol- (NPS-2143) and Quinazolinone-Derived Calcilytics (ATF936 and AXT914) Differentially Mitigate Excessive Signalling of Calcium-Sensing Receptor Mutants Causing Bartter Syndrome Type 5 and Autosomal Dominant Hypocalcemia

AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women

(2014) Markus R. John et al.   BONE

CaSR function in the intestine: Hormone secretion, electrolyte absorption and secretion, paracrine non-canonical Wnt signaling and colonic crypt cell proliferation

(2013) R. John MacLeod   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Calcium Sensing Receptor Absence Delays Postnatal Brain Development via Direct and Indirect Mechanisms

(2013) Xiu-Ling Liu et al.   MOLECULAR NEUROBIOLOGY

Mutations Affecting G-Protein Subunit α11 in Hypercalcemia and Hypocalcemia

(2013) M. Andrew Nesbit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and characterization of D410E, a novel mutation in the loop 3 domain of CASR, in autosomal dominant hypocalcemia and a therapeutic approach using a novel calcilytic, AXT914

(2012) So Young Park et al.   CLINICAL ENDOCRINOLOGY

Recombinant Human Parathyroid Hormone Therapy (1-34) in an Adult Patient with a Gain-of-Function Mutation in the Calcium-Sensing Receptor—A Case Report

(2012) Michael Gonzales et al.   Endocrine Practice

Identification of Molecular Phenotypes and Biased Signaling Induced by Naturally Occurring Mutations of the Human Calcium-Sensing Receptor

(2012) Katie Leach et al.   ENDOCRINOLOGY

Two novel mutations of the calcium-sensing receptor gene affecting the same amino acid position lead to opposite phenotypes and reveal the importance of p.N802 on receptor activity

(2012) Anne-Sophie Lia-Baldini et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Activating mutations in the calcium-sensing receptor: genetic and clinical spectrum in 25 patients with autosomal dominant hypocalcaemia - a German survey

(2011) Friedhelm Raue et al.   CLINICAL ENDOCRINOLOGY

The Calcium-Sensing Receptor: A Molecular Perspective

(2011) Aaron L. Magno et al.   ENDOCRINE REVIEWS

Calcilytics: antagonists of the calcium-sensing receptor for the treatment of osteoporosis

(2011) Leo Widler   Future Medicinal Chemistry

Novel Activating Mutations of the Calcium-Sensing Receptor: The Calcilytic NPS-2143 Mitigates Excessive Signal Transduction of Mutant Receptors

(2010) Saskia Letz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations

(2008) Ogo I. Egbuna et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

PTH(1-34) Replacement Therapy in a Child With Hypoparathyroidism Caused by a Sporadic Calcium Receptor Mutation

(2008) Todd A Theman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Novel Inactivating Mutations of the Calcium-Sensing Receptor: The Calcimimetic NPS R-568 Improves Signal Transduction of Mutant Receptors

(2008) Ramona Rus et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM