Review
Pharmacology & Pharmacy
Chenggui Zhang, Chunli Song
Summary: Combination therapy for osteoporosis can have different outcomes, with the combination of teriparatide and denosumab showing the most significant benefits. Further research is needed to determine optimal treatment strategies and methods.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Tadatoshi Sato, Christian D. Castro Andrade, Sung-Hee Yoon, Yingshe Zhao, William J. Greenlee, Patricia C. Weber, Usha Viswanathan, John Kulp, Daniel J. Brooks, Marie B. Demay, Mary L. Bouxsein, Bruce Mitlak, Beate Lanske, Marc N. Wein
Summary: This study identifies SIK2/SIK3 as potential drug targets for treating osteoporosis and successfully develops an orally available SIK2/SIK3 inhibitor. The inhibitor stimulates bone formation and increases bone density without apparent toxicity. These findings provide a new approach for the pharmacological treatment of osteoporosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Emily G. Atkinson, Michele Adaway, Daniel J. Horan, Crystal Korff, Angela Klunk, Ashley L. Orr, Katherine Ratz, Teresita Bellido, Lilian I. Plotkin, Alexander G. Robling, Joseph P. Bidwell
Summary: Activation of bone anabolic pathways is a promising strategy for treating severe osteoporosis. The inactivation of the Nmp4 gene enhances the bone anabolic effects of parathyroid hormone (PTH). The Prx1-expressing mesenchymal stem/progenitor cells (MSPCs) play a crucial role in the efficacy of PTH therapy.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
K. Eastman, M. Gerlach, I. Piec, J. Greeves, W. Fraser
Summary: This meta-analysis evaluated the evidence for the use of parathyroid hormone (PTH) analogues to improve fracture healing. PTH improved functional outcomes but did not affect fracture healing rate or reduce pain. The evidence for PTH analogue use in fracture healing is less clear in younger, non-osteoporotic patient populations, warranting further research.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Nitchanant Kitcharanant, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This review compiled and discussed the mechanisms underlying the effects of parathyroid hormone (PTH) on bone healing following distraction osteogenesis. The findings showed that PTH accelerates bone regeneration through its involvement in cell proliferation and differentiation, bone formation, and callus remodeling.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yuan Li, Yuran Qian, Hui Qiao, Weiyi Pan, Liang Xie, Yu Li
Summary: This study compared the effects of two osteoanabolic drugs, ABL and TPTD, on protecting alveolar bone in experimental periodontitis. The results showed that both ABL and TPTD reduced alveolar bone loss, with ABL having better osteoanabolic effects. In vitro experiments also demonstrated that ABL had higher alkaline phosphatase activity and osteoblastic gene expression compared to TPTD.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Clinical Neurology
Nida Fatima, Elie Massaad, Muhamed Hadzipasic, Ganesh M. Shankar, John H. Shin
Summary: This study confirms the efficacy of teriparatide in improving fusion rates in osteoporotic patients undergoing spinal fusion surgery. Patients treated with teriparatide had significantly higher rates of lumbar spinal fusion compared to those not receiving the treatment, with a greater likelihood of fusion compared to bisphosphonate and placebo cohorts. The treatment also showed benefits in reducing subsequent vertebral fractures, sagittal malalignment, limb VAS, and spinal VAS. Further research is needed to determine the optimal duration of treatment and timing of surgery.
NEUROSURGICAL REVIEW
(2021)
Review
Clinical Neurology
Tao-Yin Pan, Chien-Chun Chang, Hsien-Te Chen, Hsi-Kai Tsou, Ying-Chao Lin, Chin-Hsien Hsu
Summary: This study aims to evaluate the effectiveness of teriparatide in improving radiographic and functional outcomes after spinal fusion surgery for osteoporosis. Through systematic review and network meta-analysis, the results showed significant differences in radiological outcomes, with TP group exhibiting better outcomes compared to the control group.
WORLD NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Jang-Woon Kim, Narae Park, Jaewoo Kang, Yena Kim, Hyerin Jung, Yeri Alice Rim, Ji Hyeon Ju
Summary: The study developed a novel delivery system for PTHrP protein regions to improve the treatment efficacy of osteoporosis. Experimental results demonstrated that the new system can enhance bone formation, reduce bone resorption, and improve bone structure quality in treated subjects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Bin Sun, Hufei Wang, Bing Xiao, Huichun Yan, Huiqiao Wu, Rongcheng Zhang, Ying Zhang, Wen Yuan, Xing Wang, Changgui Shi
Summary: This study developed a composite hydrogel (PHC) by integrating short-chain chitosan and nanoparticulate hydroxyapatite into a covalent poly (ethylene glycol) network. The PHC hydrogel showed enhanced osteogenesis, high mechanical strength, excellent surface properties, and good biocompatibility. The hydrogel also had immunomodulatory effects, promoting M2 macrophage polarization and suppressing M1 macrophage polarization, while increasing osteogenic capacity and inhibiting osteoclast formation and resorption. Parathyroid hormone (PTH) could be effectively loaded and released in the PHC hydrogel (PTH@PHC), further improving osteogenic ability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Genetics & Heredity
Lucija Ana Vrscaj, Janja Marc, Barbara Ostanek
Summary: This study extracted a dataset of 62 miRNAs from different studies and constructed an interactome of PTH-regulated miRNAs and their target genes. Several miRNAs with significant interactions were identified, providing further understanding of the mechanism of action of PTH in bone metabolism and osteoporosis.
Article
Chemistry, Physical
Paula Buzo Frigerio, Pedro Henrique Silva Gomes-Ferreira, Fabio Roberto De Souza Batista Juliana Moura, Idelmo Rangel Garcia Junior, Daniele Botticelli, Paulo Noronha Lisboa-Filho, Roberta Okamoto
Summary: This study evaluated the behavior of repaired bone in rats after extraction, focusing on the use of PTH (teriparatide) and Biogran (R) (a biomaterial). The results showed that the use of Biogran (R) with PTH improved bone quality in healthy rats, but did not have significant effects in orchiectomized rats. Further research is needed to determine more effective doses for postoperative bone formation.
Article
Medicine, General & Internal
Moon-Soo Han, Gwang-Jun Lee, Seul-Kee Lee, Jung-Kil Lee, Bong Ju Moon
Summary: This study investigates the relationship between clinical and radiological features and bone turnover markers (BTMs) during teriparatide therapy for osteoporotic vertebral compression fractures. The results show that the levels of serum osteocalcin and serum C-terminal telopeptide of type I collagen increase significantly, while parathyroid hormone (PTH) levels decrease significantly during the teriparatide treatment, suggesting the progression of fracture.
Article
Medicine, General & Internal
Amarendra Nath Roy, Ipsita Mazumdar
Summary: The study retrospectively observed 378 osteoporosis patients who were treated with a subcutaneous TPTD dosage of 20μg every day for six months. The DEXA scores of hip joints before and after the treatment were measured. Results showed that the six-month treatment with TPTD significantly improved DEXA scores in osteoporosis patients. Dexa scores precision and sensitivity contribute to effective osteoporosis management.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Cansu Gul Koca, Sanaz Sadry, Hasan Asker, Muhammet Fatih cicek, Meryem Kosehasanogullari, Gurkan Kaya
Summary: The study demonstrates that intermittent administration of teriparatide (4mu g/kg once a day) enhances bone formation and mineralization, particularly effective in the midpalatal suture region.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.