Article
Pharmacology & Pharmacy
Jiayu Li, Yuan Qin, Chenhao Zhao, Zhi Zhang, Zhiruo Zhou
Summary: In recent years, research on tetracycline antibiotics has shifted towards their anticancer effects. Doxycycline, minocycline, and tigecycline, approved by the FDA, have been the main focus. Evidence suggests that they can control cancer progression through various mechanisms such as anti-proliferation, anti-metastasis, and promotion of autophagy or apoptosis. These antibiotics can also be used in combination with other drugs to improve patient survival. This article introduces their mechanisms of action in different cancers, discusses combination therapies, and briefly summarizes research gaps and potential directions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Angeles Nunez-Sanchez, Maria Antonia Martinez-Sanchez, Marina Verdejo-Sanchez, Paula Garcia-Ibanez, Alba Oliva Bolarin, Bruno Ramos-Molina, Diego A. Moreno, Antonio J. Ruiz-Alcaraz
Summary: This study analyzed the anti-leukemic activity of various phytochemicals from cruciferous foods. The results showed that sulforaphane, chlorogenic acid, and cyanidin-3-glucoside exhibited potential as anti-leukemic agents, specifically targeting AML cells. Additionally, these compounds activated the NRF2/KEAP1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Masoumeh Fardi, Ali Mohammadi, Behzad Baradaran, Sahar Safaee
Summary: The study suggests that ZEB2 suppression through apoptosis induction could be an effective therapeutic method for myeloid leukemia, as it induces apoptosis, modulates gene expression, and reduces cell proliferation and viability.
CURRENT GENE THERAPY
(2021)
Review
Pharmacology & Pharmacy
Monique R. Bidell, Thomas P. Lodise
Summary: Oral tetracyclines have been used for over 60 years in the clinical practice for treating adult patients with skin and soft tissue infections, especially those with purulent infections. Despite their long-standing use, clinicians often consider other oral treatment options before tetracyclines for SSTIs.
Article
Dermatology
Kelsey R. van Straalen, Thrasyvoulos Tzellos, Phillipe Guillem, Farida Benhadou, Carlos Cuenca-Barrales, Mathilde Daxhelet, Mathieu Daoud, Ourania Efthymiou, Evangelos J. Giamarellos-Bourboulis, Gregor B. E. Jemec, Alexandros C. Katoulis, Anke Koenig, Elizabeth Lazaridou, Angelo Marzano, Lucas Matusiak, Alejandro Molina-Leyva, Chiara Moltrasio, Andreas Pinter, Concetta Potenza, Jorge Romani, Ditte M. Saunte, Nevena Skroza, Dimitra Stergianou, Jacek Szepietowski, Anastasia Trigoni, Eva Vilarrasa, Hessel H. van der Zee
Summary: The study demonstrated significant efficacy of both oral tetracycline treatment and clindamycin plus rifampicin combination therapy for patients with hidradenitis suppurativa after 12 weeks. There were no significant differences in efficacy between the two treatments, regardless of disease severity.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kamila Siedlecka-Kroplewska, Agata Wronska, Zbigniew Kmiec
Summary: Acute myeloid leukemia is characterized by uncontrolled proliferation of abnormal myeloid progenitor cells. Despite recent advances in treatment, prognosis remains poor, driving the search for new chemotherapeutics. Piceatannol shows promise as a chemotherapeutic agent for leukemia, but its use may be associated with the risk of multidrug resistance, suggesting the need for combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rania H. H. Abd El-Hameed, Mosaad S. S. Mohamed, Samir M. M. Awad, Bardes B. B. Hassan, Marwa Abd El-Fattah Khodair, Yara E. E. Mansour
Summary: A series of benzo[h]chromenes, benzo[f]chromenes, and benzo[h]chromeno[2,3-d]pyrimidines were synthesized and compounds 5a and 6a showed promising anti-cancer activity. These compounds suppressed cell growth in HL-60 by inducing cell cycle arrest and triggering cell apoptosis.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Milos Mandic, Maja Misirkic Marjanovic, Ljubica Vucicevic, Maja Jovanovic, Mihajlo Bosnjak, Vladimir Perovic, Biljana Ristic, Darko Ciric, Ljubica Harhaji-Trajkovic, Vladimir Trajkovic
Summary: In this study, we investigated the mechanisms and role of autophagy in the differentiation of HL-60 human acute myeloid leukemia cells induced by the protein kinase C (PKC) activator phorbol myristate acetate (PMA). We found that MAP kinases ERK and JNK control PMA-induced macrophage differentiation of HL-60 cells through TFEB/FOXO-mediated transcriptional activation and beclin-1-dependent post-translational activation of autophagy.
Review
Oncology
Giuseppe Visani, Martina Chiarucci, Sara Paolasini, Federica Loscocco, Alessandro Isidori
Summary: The treatment of acute myeloid leukemia (AML) has evolved with the discovery of new drugs that selectively target AML blasts. This has led to the inclusion of new targeted agents in clinical practice, either alone or in combination with standard chemotherapy, marking a new era in AML management. Evidence also suggests that high-risk AML patients may benefit from allogeneic stem cell transplant and maintenance therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kyung-Sook Chung, Chae-Bin Yoo, Jeong-Hun Lee, Hwi-Ho Lee, Sang-Eun Park, Hee-Soo Han, Su-Yeon Lee, Byoung-Mok Kwon, Jung-Hye Choi, Kyung-Tae Lee
Summary: The study shows that 2'-HCA induces apoptosis in HL-60 cells via activation of the ROS-dependent JNK pathway, suggesting its potential as a therapeutic agent for leukemia.
Article
Biochemistry & Molecular Biology
Monaj Kumar Sarkar, Amrita Kar, Adithyan Jayaraman, Karthi Shanmugam, Vellingiri Vadivel, Santanu Kar Mahapatra
Summary: Myricitrin induces apoptosis in HL-60 leukemia cells by reducing mitochondrial membrane potential, increasing DNA fragmentation, inhibiting cell survival proteins, and inducing pro-apoptotic proteins.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Environmental Sciences
Yin-Chen Hsiao, Fu-Shin Chueh, Yi-Shih Ma, Jin-Cherng Lien, Te-Chun Hsia, Wen-Wen Huang, Yu-Cheng Chou, Po-Yuan Chen, Jing-Gung Chung, Hung-Yi Chen, Kuo-Ching Liu
Summary: The combination treatment of GEN and Asp shows a greater anti-leukemia activity on human leukemia HL-60 cells compared to GEN or Asp treatment alone. Suggestions that this combination may enhance the efficacy of Asp in inducing apoptosis in HL-60 cells.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Amandda Evelin Silva-Carvalho, Nakaly Natiely de Oliveira, Julia Viana Lafeta Machado, Daniel Carneiro Moreira, Guilherme Dotto Brand, Jose Roberto S. A. Leite, Alexandra Placido, Peter Eaton, Felipe Saldanha-Araujo
Summary: The antioxidant peptide Salamandrin-I, isolated from the skin secretion of the fire salamander, has been found to exhibit anticancer activity in human leukemia cell line HL-60, resulting in reduced cell proliferation and cell cycle arrest. The cellular toxicity of Salamandrin-I may be related to pyroptosis, as indicated by loss of mitochondrial membrane potential and hyperexpression of inflammasome components. This study provides the first evidence of the anticancer potential of Salamandrin-I peptide and offers valuable insights for cancer therapy and drug design.
Article
Spectroscopy
Yingjia Zhao, Yunyun Zhang, Xinyue Liang, Shupeng Liu, Xiumei Cao, Na Chen, Zhenyi Chen, Jianshe Yan
Summary: In this study, Raman spectroscopy was used to monitor the differentiation process of HL-60 cells into granulocytes, showing a correlation between differentiation stages and Raman characteristic regions. Support vector machine was employed to distinguish between undifferentiated and differentiated cells, achieving an average classification accuracy exceeding 84%. The results suggest the potential application of Raman spectroscopy in monitoring cell differentiation.
JOURNAL OF RAMAN SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Henoc del Rosario, Ester Saavedra, Ignacio Brouard, Daniel Gonzalez-Santana, Celina Garcia, Elena Spinola-Lasso, Carlos Tabraue, Jose Quintana, Francisco Estevez
Summary: Synthetic flavonoids with new substitution patterns show potential as anticancer drugs. In this study, twelve chalcones were synthesized and their antiproliferative effects on human tumour cells were evaluated. The most cytotoxic chalcones contained a furoyl substituent linked by an ester or an amide through the 2'-hydroxy or the 2'-amino group of the chalcone skeleton. The synthetic chalcone 2'-furoyloxy-4-methoxychalcone (FMC) displayed higher potency than the antineoplastic agent etoposide and had less toxicity on normal blood cells. The mechanism of action involved cell cycle arrest, induction of apoptosis, and inhibition of tubulin polymerization, and depended on the generation of reactive oxygen species.
BIOORGANIC CHEMISTRY
(2022)