Article
Environmental Sciences
Clement Baratange, Severine Paris-Palacios, Isabelle Bonnard, Laurence Delahaut, Dominique Grandjean, Laurence Wortham, Stephanie Sayen, Andrea Gallorini, Jean Michel, David Renault, Florian Breider, Jean-Luc Loizeau, Claudia Cosio
Summary: In this study, the effects of carbamazepine (CBZ) and mercury (Hg) on zebra mussels were evaluated. It was found that the co-exposure of these two pollutants had the most significant impact, reducing the levels of various metabolites and causing structural changes in cells and organelles. Single exposures to CBZ or Hg had smaller effects, but still resulted in changes in metabolites and cellular structures. Additionally, both single and co-exposures increased the antioxidant response in gills and digestive glands. These findings highlight the importance of considering molecular toxicity pathways in predicting the effects of pollutants on organisms in complex environmental conditions.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Dezhen Tu, Ravikanth Velagapudi, Yun Gao, Jau-Shyong Hong, Hui Zhou, Hui-Ming Gao
Summary: This study investigates the expression patterns, regulatory mechanisms, and pathological roles of neuronal NADPH oxidase in inflammation-associated neurodegeneration. The results show that NOX2 is persistently upregulated in neurons during chronic neuroinflammation and is associated with oxidative stress and neurodegeneration. Inhibition of neuronal NOX2 can block the degenerative effects of inflammatory mediators and prevent neurodegeneration.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xingzhu Liu, Chang Xu, Wanglong Xiao, Nianlong Yan
Summary: The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a highly conserved transcription factor that plays a crucial role in cellular stress adaptation by responding to oxidative stress and proteotoxic stress. Its functions include inducing antioxidative responses and regulating the ubiquitin-proteasome system and ER-associated degradation. Abnormal stress adaptations of NFE2L1 contribute to the pathophysiological complications of various diseases.
Article
Biochemistry & Molecular Biology
Sara R. Oliveira, Pedro A. Dionisio, Maria M. Gaspar, Maria B. T. Ferreira, Catarina A. B. Rodrigues, Rita G. Pereira, Monica S. Estevao, Maria J. Perry, Rui Moreira, Carlos A. M. Afonso, Joana D. Amaral, Cecilia M. P. Rodrigues
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuronal loss, with necroptosis playing a role in various neurodegenerative diseases including PD. The compound Oxa12 has been identified as a novel inhibitor of necroptosis, showing potential for mitigating PD pathogenesis in vivo through protection against dopaminergic neuronal loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Cem Emeksiz
Summary: This study highlights the importance of measuring electromagnetic radiation levels caused by radio frequencies and extremely low frequencies. The researchers conducted measurements in a shopping mall and found that the SAR values exceeded the safe limit in the playland and electronics sectors, posing potential health risks, especially for children.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Behavioral Sciences
Moein Salari, Seyed Hassan Eftekhar-Vaghefi, Majid Asadi-Shekaari, Khadijeh Esmaeilpour, Somayeh Solhjou, Maryam Amiri, Meysam Ahmadi-Zeidabadi
Summary: In this study, we examined the effects of ketamine and extremely low-frequency electromagnetic fields (ELF-EMF) on depression-like behavior, learning and memory, and the expression of GFAP, caspase-3, p53, BDNF, and NMDA receptor in animals subjected to chronic unpredictable stress (CUS). The results revealed that the combination of ketamine and ELF-EMF had adverse effects on animals under chronic unpredictable stress.
BRAIN AND BEHAVIOR
(2023)
Article
Construction & Building Technology
Jiansong Wu, Boyang Sun, Zhuqiang Hu, Letian Li, Huizhong Zhu
Summary: In recent years, extremely cold events have been frequent globally, posing a serious threat to human health and safety. A study was conducted to investigate the physiological responses and thermal sensation of humans in extreme cold environments. The results showed that the ear is the most sensitive to temperature changes and blood pressure increased significantly during cold exposure, while heart rate decreased. The establishment of a transition space can help alleviate the pressure stimulus of a large temperature difference, and there are functional correlations between local skin temperature and thermal perception.
BUILDING AND ENVIRONMENT
(2021)
Review
Oncology
Mengqian Huang, Parker Li, Feng Chen, Zehao Cai, Shoubo Yang, Xiaohong Zheng, Wenbin Li
Summary: This review summarizes the five significant underlying mechanisms and applications of ELF-PEMF in the treatment of gliomas, as well as discusses the prospects of combining ELF-PEMF with conventional therapy for treating gliomas.
Article
Biology
Jiansong Wu, Zhuqiang Hu, Zhaoxing Han, Yin Gu, Lin Yang, Boyang Sun
Summary: The study investigates human physiological responses to exposure in extremely cold environments, finding that local skin temperature and blood pressure are the most critical indicators. Finger temperature and blood pressure are the most affected indexes.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Doaa Qubty, Kati Frid, Meirav Har-Even, Vardit Rubovitch, Ruth Gabizon, Chaim G. Pick
Summary: Traumatic Brain Injury (TBI) is a common cause of neurological damage in young populations and is considered a risk factor for neurodegenerative diseases. A study has shown that Nano formulation of Pomegranate seed oil can prevent cognitive and behavioral decline caused by TBI, reduce neuronal death, gliosis, and mitochondrial damage, and increase levels of SIRT1 and SYP in the brain.
Article
Cell Biology
Caroline M. S. Marques, Rafael N. Gomes, Tatiana Pedron, Bruno L. Batista, Giselle Cerchiaro
Summary: The study investigates the involvement of cellular prion protein (PrPC) in neuroprotection under oxidative stress. The presence of PrPC showed resistance to oxidative stress in astrocytes, and PrPC plays a role in metal homeostasis and prevents protein aggregation. Additionally, PrPC can translocate SOD1 to cell nuclei under oxidative stress, potentially controlling DNA damage. Overall, the study suggests that PrPC activates cellular response and defense against oxidative stress, protecting neurons and ensuring astrocyte functionality.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
German Plascencia-Villa, George Perry
Summary: Alzheimer's disease is a progressive brain disorder characterized by memory and thinking impairment, with various pathological features such as abnormal protein aggregates, synaptic dysfunction, and oxidative stress. Oxidative stress, often overlooked or considered a consequence of dementia, plays a crucial role in AD progression and neuronal death. Recognizing oxidative stress as a key factor in AD has led to the development of alternative therapeutic interventions and preventive strategies for this devastating neurodegenerative disease.
Article
Biochemistry & Molecular Biology
Domenico Nuzzo, Pasquale Picone, Costanza Giardina, Miriana Scordino, Giuseppa Mudo, Mario Pagliaro, Antonino Scurria, Francesco Meneguzzo, Laura M. Ilharco, Alexandra Fidalgo, Rosa Alduina, Alessandro Presentato, Rosaria Ciriminna, Valentina Di Liberto
Summary: The Lemon IntegroPectin obtained through hydrodynamic cavitation of organic lemon waste has shown significant neuroprotective activity in vitro, highlighting the potential for further research on its efficacy in preventing, delaying, or even curing neurological diseases.
Article
Biochemistry & Molecular Biology
Byung Hee Han, Brooke Cofell, Emily Everhart, Courtney Humpal, Sam-Sik Kang, Sang Kook Lee, Jeong Sook Kim-Han
Summary: This study demonstrates that the natural polyphenol amentoflavone (AMF) can increase cellular uptake and clearance of amyloid beta-protein (Aβ), potentially offering a therapeutic approach for Alzheimer's disease (AD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ilenia Martinelli, Mathieu Cinato, Sokhna Keita, Dimitri Marsal, Valentin Antoszewski, Junwu Tao, Oksana Kunduzova
Summary: The study found that short-term exposure to EMF did not have a significant effect on the myocardial antioxidant defense system and apoptotic cell death in cardiac cells and tissues.
Review
Neurosciences
Faijan Akhtar, Parth K. Patel, Md Belal Bin Heyat, Saba Yousaf, Atif Amin Baig, Rashenda Aziz Mohona, Muhamad Malik Mutoffar, Tanima Bhattacharya, Bibi Nushrina Teelhawod, Jian Ping Li, Mohammad Amjad Kamal, Kaishun Wu
Summary: This study aims to determine the research volume conducted on students who are affected by smartphone addiction and design a database. It also provides a comprehensive image of smartphone-addicted students and highlights critical problems for future research.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Fariya Khan, Salman Akhtar, Mohammad Amjad Kamal
Summary: The emerging field of nanoinformatics, combining bioinformatics and nanotechnology, offers new research opportunities for the development of personalized nanomedicine in cancer therapy. This approach has the potential to revolutionize the field of precision medicine by providing non-invasive and versatile treatment options for cancer patients.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Athanasios Alexiou, Christos Tsagkaris, Stylianos Chatzichronis, Andreas Koulouris, Ioannis Haranas, Ioannis Gkigkitzis, Georgios Zouganelis, Nobendu Mukerjee, Swastika Maitra, Niraj Kumar Jha, Gaber El-Saber Batiha, Mohammad Amjad Kamal, Michail Nikolaou, Ghulam Md Ashraf
Summary: Even though cancer therapies have improved, the number of patients has increased, making cancer the fifth deadliest disease. Efficient drug delivery systems must overcome barriers and maximize drug delivery while limiting side effects. Quantum-inspired solutions, such as using quantum tunneling phenomenon in scanning tunneling microscopes, allow for accurate mapping of tumor surfaces and efficient nanodrug design.
CURRENT MEDICINAL CHEMISTRY
(2023)
Letter
Public, Environmental & Occupational Health
Faisal Ismail, Atiya Farag, Soghra Haq, Mohammad Amjad Kamal
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2023)
Review
Endocrinology & Metabolism
Nobendu Mukerjee, Swastika Maitra, Subhradeep Roy, Shaswata Modak, Mohammad Mehedi Hasan, Biswajit Chakraborty, Arabinda Ghosh, Asmita Ghosh, Mohammad Amjad Kamal, Abhijit Dey, Ghulam Md Ashraf, Sumira Malik, Md Habibur Rahman, Badrah S. Alghamdi, Adel Mohammad Abuzenadah, Athanasios Alexiou
Summary: Glioblastoma is an aggressive tumor that hinders normal brain function, and the inability of the skull to expand results in increased pressure in the brain. Recent studies have found that SNPs play a significant role in the development and spread of glioblastoma, with many GB-related SNPs being highly abundant in the promoter region, creating genetic vulnerability to glioma.
METABOLIC BRAIN DISEASE
(2023)
Editorial Material
Neurosciences
Mohammad Amjad Kamal, Athanasios Alexiou, Asma Perveen
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Syed Mohd Danish Rizvi, Talib Hussain, Farhan Alshammari, Hana Sonbol, Nabeel Ahmad, Syed Shah Mohammed Faiyaz, Mohammad Amjad Kamal, El-Sayed Khafagy, Afrasim Moin, Amr Selim Abu Lila
Summary: Infections caused by resistant bacterial pathogens have become more complicated for clinicians worldwide. Researchers have developed gold nanoparticles (AuNPs) that efficiently deliver cephalosporin antibiotics to resistant clinical pathogens. The synthesized AuNPs showed high stability and were effective against resistant strains of E. coli and K. pneumoniae. This study suggests that investing in a nano-antibiotic strategy may be a better approach to overcome resistance.
Review
Pharmacology & Pharmacy
Syed Mohd Danish Rizvi, Amr Selim Abu Lila, Afrasim Moin, Talib Hussain, Mohammad Amjad Kamal, Hana Sonbol, El-Sayed Khafagy
Summary: The advent of new antibiotics has helped control severe bacterial infections, but inappropriate use and resistance mechanisms still pose challenges. Extended-spectrum beta-lactamases (ESBLs) genes have become one of the most common approaches for bacteria to develop resistance. Nanotechnology, specifically gold nanoparticles (AuNPs), has shown potential in converting unresponsive antibiotics into potent ones against resistant strains.
Article
Pharmacology & Pharmacy
Shailja Singhal, Utsang Kumar, Taha Alqahtani, Igor Vladimirovich Rzhepakovsky, Rekha Khandia, Megha Pandey, Saud Alqahtani, Hanan Alharbi, Mohammad Amjad Kamal
Summary: Apoptosis and autophagy are two fundamental processes involved in maintaining homeostasis, and they can be initiated by a common stimulus. Autophagy has been implicated in various diseases, including viral infections. Genetic manipulations that alter gene expression could be a strategy to control viral infection.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Katherine O. Kopp, Margaret E. Greer, Elliot J. Glotfelty, Shih-Chang Hsueh, David Tweedie, Dong Seok Kim, Marcella Reale, Neil Vargesson, Nigel H. Greig
Summary: The immunomodulatory imide drug (IMiD) class, consisting of thalidomide and its derivatives lenalidomide and pomalidomide, has greatly improved the treatment of specific cancers and possesses potent anticancer and anti-inflammatory actions. These actions are mainly mediated by the binding of IMiDs to the human protein cereblon, resulting in the modification of protein degradation and the emergence of new substrate proteins. However, this binding also leads to adverse effects, including teratogenicity.
Article
Biochemistry & Molecular Biology
Divyanshi Shukla, Amer M. Alanazi, Siva Prasad Panda, Vivek Dhar Dwivedi, Mohammad Amjad Kamal
Summary: In this study, a QSAR-based chemical library screening was conducted to identify potential RdRp inhibitors from the Meliaceae family. The top two hit compounds were further analyzed using molecular docking and molecular dynamics simulations, which showed stable binding interactions with RdRp and comparable binding energies to known inhibitors. Compound IMPHY009135 exhibited the strongest binding affinity, while compound IMPHY009276 showed the most stable structure. These findings suggest that these two compounds could be potential lead compounds for developing novel antiviral agents against ZIKV.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biology
Gnana Deepthi Medarametla, Ripudaman Singh Kahlon, Lampimukhi Mahitha, Sanobar Shariff, Naga Praneeth Vakkalagadda, Hitesh Chopra, Mohammad Amjad Kamal, Neil Patel, Yashendra Sethi, Nirja Kaka
Summary: Amyloidosis is a protein deposition disorder that damages organ function by causing the accumulation of insoluble fibrils in bodily tissues. Cardiac amyloidosis, a severe and under-reported condition, involves the accumulation of amyloid in the extracellular area of the myocardium, leading to thickening and stiffening of ventricular walls. The incidence of cardiac amyloidosis has been slowly increasing, and this study aims to provide a comprehensive understanding of its pathophysiology and clinical presentation, as well as offer up-to-date approaches for diagnosis and therapy. Genetic mutations and advancements in imaging and diagnostic methods contribute to the growing incidence of cardiac amyloidosis. Early detection can help improve treatment outcomes, and various therapeutic approaches are being explored to impede disease progression and enhance clinical outcomes.
Review
Biochemistry & Molecular Biology
Ligen Yu, Mohd Khanapi Abd Ghani, Alessio Aghemo, Debmalya Barh, Matteo Bassetti, Fausto Catena, Gaetano Gallo, Ali Gholamrezanezhad, Mohammad Amjad Kamal, Amos Lal, Kamal Kant Sahu, Shailendra K. Saxena, Ugo Elmore, Farid Rahimi, Chiara Robba, Yuanlin Song, Zhengyuan Xia, Boxuan Yu
Summary: This study analyzed keywords and found that factors such as the immune system and nutrition are related to COVID-19. It proposed that the human immune system is a complex system that employs self-destruct and rebuild strategies to fight microbial infections. Microbial infections may be self-limiting and provide essential nutrition for the patient. The study also discussed possible strategies to mitigate COVID-19, including vaccination.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Computer Science, Artificial Intelligence
Pongtep Weerapong, Kotaro Hashikura, Md Abdus Samad Kamal, Iwanori Murakami, Kou Yamada
Summary: This paper discusses a method to evaluate the prediction accuracy of a wheelchair-occupant simulation model by comparing it with real-world experimental results. Different types of seat cushions are used in the model to simulate the low-frequency vibration waves caused by the interaction between wheelchair tires and the ground. The analysis shows that the occupant's torso is most affected by the vibration, resulting in the maximum displacement of organs; and the foam-based cushion performs the best in reducing the amplitude of displacement responses.
INTERNATIONAL JOURNAL OF INNOVATIVE COMPUTING INFORMATION AND CONTROL
(2023)
Article
Computer Science, Artificial Intelligence
Sorawin Phukapak, Daisuke Koyama, Kotaro Hashikura, Md Abdus Samad Kamal, Kou Yamada
Summary: In this paper, the parameterization of all disturbance observers for periodic output disturbances is examined. Disturbance observers have been used to estimate disturbances in plants. While previous papers have clarified the parameterization of all disturbance observers for plants, none have focused on periodic output disturbances. This paper proposes a parameterization method for all disturbance observers for periodic output disturbances.
INTERNATIONAL JOURNAL OF INNOVATIVE COMPUTING INFORMATION AND CONTROL
(2023)
