IL-7 Receptor Recovery on CD8 T-Cells Isolated from HIV+ Patients Is Inhibited by the HIV Tat Protein

IL-7 downregulates IL-7Rα expression in human CD8 T cells by two independent mechanisms

(2012) Feras M Ghazawi et al.   IMMUNOLOGY AND CELL BIOLOGY

A combination HIV vaccine based on Tat and Env proteins was immunogenic and protected macaques from mucosal SHIV challenge in a pilot study

(2011) Flavia Ferrantelli et al.   VACCINE

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

(2010) Fabienne Rayne et al.   EMBO JOURNAL

Soluble HIV Tat Protein Removes the IL-7 Receptor  -Chain from the Surface of Resting CD8 T Cells and Targets It for Degradation

(2010) E. M. Faller et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Immunization with HIV-1 Tat Reduces Immune Activation and Loss of Regulatory T-Cells and Improves Immune Function in Subjects on HAART

(2010) Barbara Ensoli et al.   PLoS One

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

(2009) I. Sereti et al.   BLOOD

Hepatic Interleukin-7 Expression Regulates T Cell Responses

(2009) Yukihisa Sawa et al.   IMMUNITY

IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells

(2009) E. Faller et al.   INTERNATIONAL IMMUNOLOGY

Mechanism for HIV-1 Tat Insertion into the Endosome Membrane

(2009) Hocine Yezid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The preventive phase I trial with the HIV-1 Tat-based vaccine

(2009) Barbara Ensoli et al.   VACCINE

Containment of Infection in Tat Vaccinated Monkeys After Rechallenge with a Higher Dose of SHIV89.6Pcy243

(2009) Alessandra Borsetti et al.   VIRAL IMMUNOLOGY

Down‐Regulation of Interleukin‐7 Receptor (CD127) in HIV Infection Is Associated with T Cell Activation and Is a Main Factor Influencing Restoration of CD4+Cells after Antiretroviral Therapy

(2008) José M. Benito et al.   JOURNAL OF INFECTIOUS DISEASES