Therapeutic Immunization with HIV-1 Tat Reduces Immune Activation and Loss of Regulatory T-Cells and Improves Immune Function in Subjects on HAART

Role of HIV-1 Tat in AIDS pathogenesis: its effects on cytokine dysregulation and contributions to the pathogenesis of opportunistic infection

(2010) James Chun-bong Li et al.   AIDS

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

(2010) Fabienne Rayne et al.   EMBO JOURNAL

Impact of Viral Dose and Major Histocompatibility Complex Class IB Haplotype on Viral Outcome in Mauritian Cynomolgus Monkeys Vaccinated with Tat upon Challenge with Simian/Human Immunodeficiency Virus SHIV89.6P

(2010) A. Cafaro et al.   JOURNAL OF VIROLOGY

Antiretroviral therapy and management of HIV infection

(2010) Paul A Volberding et al.   LANCET

Dysfunctional B-cell responses during HIV-1 infection: implication for influenza vaccination and highly active antiretroviral therapy

(2010) Alberto Cagigi et al.   LANCET INFECTIOUS DISEASES

HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs

(2010) Christoph C Carter et al.   NATURE MEDICINE

HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals

(2010) D. Trono et al.   SCIENCE

Incomplete Peripheral CD4+Cell Count Restoration in HIV‐Infected Patients Receiving Long‐Term Antiretroviral Treatment

(2009) Colleen F. Kelley et al.   CLINICAL INFECTIOUS DISEASES

Incomplete Reconstitution of T Cell Subsets on Combination Antiretroviral Therapy in the AIDS Clinical Trials Group Protocol 384

(2009) Gregory K. Robbins et al.   CLINICAL INFECTIOUS DISEASES

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

Immobilized HIV-1 Tat protein promotes gene transfer via a transactivation-independent mechanism which requires binding of Tat to viral particles

(2009) Filomena Nappi et al.   JOURNAL OF GENE MEDICINE

HIV-1 Tat Addresses Dendritic Cells to Induce a Predominant Th1-Type Adaptive Immune Response That Appears Prevalent in the Asymptomatic Stage of Infection

(2009) E. Fanales-Belasio et al.   JOURNAL OF IMMUNOLOGY

Cellular Levels of HIV Unspliced RNA from Patients on Combination Antiretroviral Therapy with Undetectable Plasma Viremia Predict the Therapy Outcome

(2009) Alexander O. Pasternak et al.   PLoS One

Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children

(2009) S. Pensieroso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy

(2009) J. B. Dinoso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?

(2009) Grant R Campbell et al.   Retrovirology

The Challenge of Finding a Cure for HIV Infection

(2009) D. D. Richman et al.   SCIENCE

Phase I therapeutic trial of the HIV-1 Tat protein and long term follow-up

(2009) Olimpia Longo et al.   VACCINE

The preventive phase I trial with the HIV-1 Tat-based vaccine

(2009) Barbara Ensoli et al.   VACCINE

Containment of Infection in Tat Vaccinated Monkeys After Rechallenge with a Higher Dose of SHIV89.6Pcy243

(2009) Alessandra Borsetti et al.   VIRAL IMMUNOLOGY

The therapeutic phase I trial of the recombinant native HIV-1 Tat protein

(2008) Barbara Ensoli et al.   AIDS

Cellular Reservoirs of HIV-1 and their Role in Viral Persistence

(2008) Aikaterini Alexaki et al.   CURRENT HIV RESEARCH

Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

(2008) Joseph D. Miller et al.   IMMUNITY

The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+T cells in HIV-1-infected typical progressors, but not in long-term non-progressors

(2008) Yanmei Jiao et al.   IMMUNOLOGY

Preservation of FoxP3+ Regulatory T Cells in the Peripheral Blood of Human Immunodeficiency Virus Type 1-Infected Elite Suppressors Correlates with Low CD4+ T-Cell Activation

(2008) A. J. Chase et al.   JOURNAL OF VIROLOGY

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

(2008) Fabio Malavasi et al.   PHYSIOLOGICAL REVIEWS

HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo

(2007) A. Biancotto et al.   BLOOD

Immune activation and inflammation in HIV-1 infection: causes and consequences

(2007) V Appay et al.   JOURNAL OF PATHOLOGY

The Tat protein broadens T cell responses directed to the HIV-1 antigens Gag and Env: Implications for the design of new vaccination strategies against AIDS

(2007) Riccardo Gavioli et al.   VACCINE

Human macrophages support persistent transcription from unintegrated HIV-1 DNA

(2007) Jeremy Kelly et al.   VIROLOGY