Review
Biotechnology & Applied Microbiology
Namrata Dhaka, Rita Sharma
Summary: Research has shown that miRNAs play a key role in seed development in plants, regulating traits such as seed size, nutritional content, vigor, and shattering. Co-localization of miRNAs with seed-related QTLs offers new avenues for trait improvement, while global analysis and recent findings help optimize agronomically relevant seed traits.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ling Ji, Xinyi Li, Shushu He, Song Chen
Summary: This review introduces the pathways and related microRNAs involved in osteoclastogenesis, discusses the clinical potential of targeting microRNAs for the treatment of osteoclast-mediated bone resorption, and the challenges of avoiding potential side effects and producing efficient delivery methods.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hossein Ghanizadeh, Christopher E. Buddenhagen, Kerry C. Harrington, Andrew G. Griffiths, Zachary Ngow
Summary: Resistance to ACCase-inhibiting herbicide pinoxaden in a population of L. perenne is characterized by the concurrent action of cytochrome P-450 activity enhancement and a rare target-site mutation. The resistant population showed different levels of resistance to other herbicides but remained susceptible to clethodim.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Review
Cell Biology
Shintaro Komatsu, Hiroki Kitai, Hiroshi I. Suzuki
Summary: MicroRNAs (miRNAs) act as versatile regulators of gene expression at the post-transcriptional level. Recent studies have uncovered the mechanisms involved in miRNA biogenesis, including the processing of both canonical and non-canonical miRNAs. Additionally, the complex interactions between miRNAs and their targets have been explored, revealing target-mediated miRNA degradation and cooperative regulation by multiple miRNAs. These findings highlight the coordinated regulation of miRNA biogenesis and miRNA-target interaction in miRNA biology.
Review
Immunology
Cen Chang, Lingxia Xu, Runrun Zhang, Yehua Jin, Ping Jiang, Kai Wei, Linshuai Xu, Yiming Shi, Jianan Zhao, Momiao Xiong, Shicheng Guo, Dongyi He
Summary: MicroRNAs (miRNAs) play crucial roles in the pathogenesis, diagnosis, and therapeutic intervention of rheumatoid arthritis (RA). They regulate gene expression, immune system differentiation, and serve as potential biomarkers and therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Nicolas Homberg, Mariana Galvao Ferrarini, Christine Gaspin, Marie-France Sagot
Summary: MicroRNAs (miRNAs) regulate gene expression in animals and plants by pairing with messenger RNAs (mRNAs). Accurately identifying the interacting mRNAs and their interaction sites with a given miRNA is crucial for understanding the regulatory network of an organism. However, computational predictions of miRNA-mRNA interactions, despite being the first step used, have a high rate of false-positive predictions. This paper aims to revisit the importance of certain features, such as miRNA seed anchoring and mRNA accessibility, by using CLASH datasets.
Article
Cell Biology
Manal A. A. Moustafa, Durbba Nath, John J. Georrge, Supriyo Chakraborty
Summary: This study investigated the overexpressed genes and their associated microRNAs in oral cancer. Using in-house software, specific microRNAs targeting these genes were identified and their interactions were evaluated. The stability of target regions and the GC content of the overexpressed genes were analyzed. Gene ontology analysis was performed to understand the involvement of these genes in biological processes, molecular functions, and cellular components.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Chiara De Santi, Frances K. Nally, Remsha Afzal, Conor P. Duffy, Stephen Fitzsimons, Stephanie L. Annett, Tracy Robson, Jennifer K. Dowling, Sally-Ann Cryan, Claire E. McCoy
Summary: Macrophages are crucial in innate immunity, but can lead to inflammatory diseases if persistently in a pro-inflammatory state. Reprogramming macrophages towards an anti-inflammatory phenotype through targeting a mitochondrial enzyme like arginase 2 shows promise in modulating macrophage phenotype.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biology
Yirong Wang, Xiaolu Tang, Jian Lu
Summary: The evolution of microRNAs in bilaterian animals has been extensively studied, with a focus on both convergent and divergent evolution. Recent evidence suggests that the miRNA pathway might have already existed in the last common ancestor of eukaryotes, and differences in animal and plant lineages arise from lineage-specific innovations and losses. The miRNA repertoire has expanded through de novo creation and duplication processes, with many newly emerged miRNAs being lineage-specific. MiRNA clustering and seed mimicry contribute to the convergent molecular evolution of miRNAs, and miRNAs from different sources can converge to degrade maternal mRNAs during animal development. MiRNAs can evolve across species due to changes in sequence, seed shifting, arm switching, and spatiotemporal expression patterns, resulting in variations in target sites among orthologous miRNAs.
BIOLOGICAL REVIEWS
(2023)
Article
Engineering, Civil
Jawad Fayaz, Farzin Zareian
Summary: The algorithm efficiently simulates site-based ground motions by establishing predictive relations between model parameters and spectral acceleration spectra. It carefully selects model parameters statistically likely to generate ground motions possessing the required target spectrum. Unlike traditional scaling methods, this algorithm does not alter the characteristics of ground motions, leading to more realistic simulations. Demonstrations show that the proposed algorithm results in statistically consistent responses compared to conventional methods.
EARTHQUAKE ENGINEERING & STRUCTURAL DYNAMICS
(2021)
Review
Immunology
Sara Assadiasl, Misagh Rajabinejad, Narjes Soleimanifar, Farideh Makiyan, Esfandiar Azizi, Alireza Rezaiemanesh, Mohammad Hossein Nicknam
Summary: Rheumatoid arthritis and ankylosing spondylitis are two common rheumatic disorders characterized by persistent inflammatory joint disease. This review provides an overview of the most important signaling pathways controlled by miRNAs in these diseases.
INFLAMMOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Milad Ashrafizadeh, Ali Zarrabi, Sima Orouei, Kiavash Hushmandi, Azadeh Hakimi, Amirhossein Zabolian, Salman Daneshi, Saeed Samarghandian, Behzad Baradaran, Masoud Najafi
Summary: This article discusses the impact of chemoresistance on cancer treatment, emphasizing the importance of autophagy and miRs in cancer cells, as well as their roles in cancer chemotherapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Immunology
Miaoran Xia, Bingbing Wang, Zihan Wang, Xulong Zhang, Xi Wang
Summary: NK cells are a heterogeneous and plastic population that can directly kill target cells without prior immunization, with their activation controlled by the balance of multiple germline-encoded activating and inhibitory receptors. Epigenetic regulation plays an important role in NK cell-mediated antitumor immunity, and NK cell-based immunotherapy is considered a promising strategy for cancer treatment. By targeting intrinsic epigenetic regulators alone or in combination with other strategies, there is potential to enhance NK cell-mediated antitumor cytotoxicity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Abolfazl Akbari, Meghdad Sedaghat, Javad Heshmati, Seidamir Pasha Tabaeian, Sadegh Dehghani, Ana Beatriz Pizarro, Zahra Rostami, Shahram Agah
Summary: Curcumin, a bioactive compound found in the Rhizomes of Curcuma longa, is well-known for its chemopreventive and anti-cancer properties. It exerts its effects on gastrointestinal cancers through antioxidant and anti-inflammatory mechanisms, interacting with various transcription factors and signaling molecules. Additionally, Curcumin has been found to regulate the expression of pathogenic miRNAs in gastric, colorectal, esophageal, and liver cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Brooke King, Bradley A. Krisanits, Qi J. Guo, Bobbie Blake, Lourdes M. Nogueira, Gurbani Jolly, Arabia Satterwhite, David P. Turner, Stanley Hoffman, Ashley Evans-Knowell, Victoria J. Findlay
Summary: In the US, there is a persistent mortality disparity between black and white women with breast cancer, with black women having a 41% higher death rate. Recent studies suggest that this racial disparity may be related to biological factors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lu Liu, Wenlong Xu, Yao Ni, Zhipeng Xu, Binbin Cui, Jiaqi Liu, Huanhuan Wei, Wentao Xu
Summary: This article presents a nanowire-channel intrinsically stretchable neuromorphic transistor (NISNT) that can perceive tactile and visual information and emulate neuromorphic processing. The NISNT shows excellent stretching endurance, with stable electrical properties after 1000 stretch cycles. It is used as a multisensitive afferent nerve attached to fingers for conformal strain sensing and gesture recognition. The shape changes represented by excitatory postsynaptic current in each device are analyzed using softmax activation processing of the neural network to recognize gestures.
Article
Materials Science, Multidisciplinary
Yaodong Xue, Yongfeng Cheng, Qing Li, Kai Wang, Wenlong Xu, Weisheng Du
Summary: The mechanical failure mechanism of rock masses containing internal joints under impact loading was studied using a combination of experimental and numerical methods. A dynamic failure mechanism model was proposed based on the research results, which is of great significance for understanding the failure process of rocks containing joints and for engineering applications.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2023)
Article
Materials Science, Multidisciplinary
Kangkang Yao, Yin Zhang, Wenlong Xu, Jianing Li, Fang Wang, Minwei Xu, Fanghua Tian, Chao Zhou, Sen Yang
Summary: In this study, a core-shell nanostructure composed of CoFe2O4 as the core and Prussian blue analog as the shell (CoFe2O4@PBA) was synthesized. The introduction of a photo-sensitive shell resulted in unexpected changes in saturation magnetization and coercivity of the hybrid material under illumination at 5 K. The photo-magnetic effect was attributed to the valence state transition of Fe ions in CoFe2O4 induced by the optical-excited electrons transfer from the CoFe PBA shell to the CoFe2O4 core.
Article
Materials Science, Composites
Dong Ma, Cheng Wang, Wenlong Xu, Shiyu Jia
Summary: This study focuses on improving the shock wave mitigation performance of polymer composites by adding different nanocarbon fillers. The results show that the addition of nanocarbon fillers can enhance the shock wave mitigation ability of epoxy resin, with graphene fillers demonstrating the best effect.
POLYMER COMPOSITES
(2022)
Article
Chemistry, Multidisciplinary
Yuanyan Wei, Qihang Chen, Sijing Huang, Yingchao Liu, Yinan Li, Yang Xing, Danfang Shi, Wenlong Xu, Weitao Liu, Zhi Ji, Bingrui Wu, Xiaoning Chen, Jianhai Jiang
Summary: This study reveals that the low expression of MAN1A1 in glioma stem cells (GSCs) results in the formation of high-mannose type N-glycan on CD133. The interaction between CD133 and DNMT1 through high-mannose type N-glycan activates p21 and p27, maintaining the slow-cycling state and promoting chemotherapy resistance and tumorigenesis in GSCs.
Article
Agricultural Engineering
Jinwu Wang, Changsu Xu, Wenlong Xu, Zuodong Fu, Qi Wang, Han Tang
Summary: This study investigates the movement and conveying characteristics of rice grains under different unloading angles using a discrete element model and numerical simulation. The results show that the voids ratio between particles gradually decreases with increasing axial distance for grains with a -30 degrees inclination, while it first remains unchanged and then increases for grains with a -15 degrees or -30 degrees inclination. The maximum average velocity of grain flow occurs near the inlet and outlet of the auger. The axial flow performance decreases with increasing unloading angle and moisture content of rice.
BIOSYSTEMS ENGINEERING
(2022)
Article
Fisheries
Yang Du, Wenlong Xu, Ting Wu, Hao Li, Xiaoman Hu, Jiong Chen
Summary: This study found that Lactobacillus plantarum Ep-M17 can potentially be used as a probiotic to promote the growth and improve disease resistance in shrimp by regulating the nutritional immune response and gut flora.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Environmental Sciences
Ang Lu, Peng Tian, Xingmin Mu, Guangju Zhao, Qingyu Feng, Jianying Guo, Wenlong Xu
Summary: This study assessed land degradation changes in the Huangfuchuan watershed of the Loess Plateau by considering different types of land degradation. The results showed an increase in vegetation cover and a decrease in soil erosion rate, indicating significant success in land degradation prevention in the region.
Article
Materials Science, Ceramics
Wenzhi Sun, Liyan Fan, Xinxin Zhang, Denghu Wei, Mengmeng Jiao, Wenlong Xu, Hongwu Zhang
Summary: The properties of orange-emitting SLNMPO-0.5:Eu2+ and SLNMPO-1:Eu2+ phosphors with broad emission bands were investigated. It was found that they exhibited better photoluminescence properties and more red emissions compared to SMPO:Eu2+. These phosphors have the potential to be used in high-quality warm white light-emitting diode (WLED) devices.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Materials Science, Characterization & Testing
Yaodong Xue, Yongfeng Cheng, Qing Li, Weisheng Du, Wenlong Xu
Summary: This paper investigates the dynamic stress intensity factor (DSIF) at the crack tip of a PMMA beam with an internal offset crack under impact loading. The stress intensity factor and velocity of the mixed-mode crack tip under static and dynamic loading were derived using the transmission caustic method. Drop hammer loading tests were conducted on different specimens with biased cracks in the beam to obtain dynamic fracture mechanics parameters. The crack initiation angle and expansion path of impact-generated expansion cracks were analyzed based on theoretical analysis, and the differences between the fracture process and specimens containing internal symmetric cracks were discussed.
Article
Environmental Sciences
Hang Lv, Guifen Wang, Wenlong Xu, Yinxue Zhang, Long Jiang
Summary: Seasonal patterns of marine net primary production (NPP) in the South China Sea (SCS) were studied using monthly climatological NPP data from 2003 to 2020. The study revealed spatial differences in NPP seasonality and its departures from climatology in extreme El Nino-Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD) years. The differences in NPP seasonality were attributed to factors such as river discharge, summer upwelling, mixing, nutricline depth, and wind-driven mixing. The study also found that extreme climate events, such as ENSO and super IOD, influenced the NPP seasonal cycle in the SCS.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Fisheries
Yang Du, Xiaoman Hu, Jifeng Chen, Wenlong Xu, Hao Li, Jiong Chen
Summary: This study investigated the effects of adding different concentrations of cup plant to the shrimp's feed on their growth performance, hepatopancreas and intestinal microstructure, gene expression, enzyme activity, as well as intestinal microorganisms and resistance to Vibrio parahaemolyticus E1 and White spot syndrome virus (WSSV) infection. The results showed that adding cup plant at different concentrations significantly improved the shrimp's growth rate, survival rate, and resistance to V. parahaemolyticus E1 and WSSV, with the best effect observed at 5% addition. The addition of cup plant also improved the shrimp's hepatopancreas and intestinal tissues, increased enzyme activity and immune-related gene expression, and regulated the composition of intestinal flora. In summary, cup plant can promote shrimp growth, enhance disease resistance, and serve as a potential environmentally-friendly alternative to antibiotics.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Computer Science, Information Systems
Chenjun Guo, Wenlong Xu, Mingming Cai, Shufan Duan, Jianbiao Fu, Xinlong Zhang
Summary: With the continuous increase of voltage level in the grid, the importance of insulating materials has been growing. However, air gaps and aging in insulating materials can lead to electrical equipment failure and decreased insulation properties. Detecting and identifying structural defects and aging states in insulating materials has always been a challenge. Terahertz spectroscopy has shown potential in detecting these issues non-destructively, and this paper reviews its basic principles and applications in air gap detection, moisture detection, and aging analysis of insulating materials.
Proceedings Paper
Neuroimaging
Ting Liu, Xing An, Yanbo Liu, Yuxi Liu, Bin Lin, Runzhou Jiang, Wenlong Xu, Longfei Cong, Lei Zhu
Summary: This paper presents a deep learning system for classifying breast lesions and grading them into six categories based on BI-RADS. The proposed system improves classification performance through a multitask soft label generating architecture and consistency supervision mechanism, resulting in predictions that are closer to the true annotations.
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION, MICCAI 2022, PT III
(2022)
Article
Optics
Xiao Yizhe, Wang Guifen, Xu Wenlong, Jiang Long, Wu Xiangbai, He Jinyan, Zhang Yinxue
Summary: Based on a comprehensive marine scientific survey in the sea area adjacent to the Yangtze Estuary, the study examines the high-frequency variation of suspended particulate matter influenced by tide. Results show that SPM concentration varies in different areas.
ACTA OPTICA SINICA
(2022)
