Efficacy of Selective PDE4D Negative Allosteric Modulators in the Object Retrieval Task in Female Cynomolgus Monkeys (Macaca fascicularis)

Phosphodiesterases: Regulators of cyclic nucleotide signals and novel molecular target for movement disorders

(2013) Sorabh Sharma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PDE4 as a target for cognition enhancement

(2013) Wito Richter et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The role of phosphodiesterases in hippocampal synaptic plasticity

(2013) Thomas M. Sanderson et al.   NEUROPHARMACOLOGY

Demystifying Brain Penetration in Central Nervous System Drug Discovery

(2012) Li Di et al.   JOURNAL OF MEDICINAL CHEMISTRY

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

(2011) O Bruno et al.   BRITISH JOURNAL OF PHARMACOLOGY

ASP3258, an orally active potent phosphodiesterase 4 inhibitor with low emetic activity

(2011) Miki Kobayashi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease

(2011) Ignacio Munoz-Sanjuan et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data

(2011) Sarah J Tabrizi et al.   LANCET NEUROLOGY

A tale of two factors: What determines the rate of progression in Huntington's disease? A longitudinal MRI study

(2011) H. Diana Rosas et al.   MOVEMENT DISORDERS

Chronic Suppression of Phosphodiesterase 10A Alters Striatal Expression of Genes Responsible for Neurotransmitter Synthesis, Neurotransmission, and Signaling Pathways Implicated in Huntington's Disease

(2010) R. J. Kleiman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

(2010) Dennis A. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF

(2010) Elena Puerta et al.   NEUROBIOLOGY OF DISEASE

The Role of Type 4 Phosphodiesterases in Generating Microdomains of cAMP: Large Scale Stochastic Simulations

(2010) Rodrigo F. Oliveira et al.   PLoS One

Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington’s disease

(2009) Carmela Giampà et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

(2009) Markus Fridén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease

(2009) Carmela Giampà et al.   NEUROBIOLOGY OF DISEASE

Altered white matter microstructure in the corpus callosum in Huntington's disease: Implications for cortical “disconnection”

(2009) H. Diana Rosas et al.   NEUROIMAGE

Antidepressant- and Anxiolytic-like Effects of the Phosphodiesterase-4 Inhibitor Rolipram on Behavior Depend on Cyclic AMP Response Element Binding Protein-Mediated Neurogenesis in the Hippocampus

(2009) Yun-Feng Li et al.   NEUROPSYCHOPHARMACOLOGY

Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

(2008) A. Nishi et al.   JOURNAL OF NEUROSCIENCE

In vivo effects of phosphodiesterase inhibition on basal cyclic guanosine monophosphate levels in the prefrontal cortex, hippocampus and cerebellum of freely moving rats

(2008) Antonella Marte et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation

(2008) S. Threlfell et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

(2008) Helen S Bateup et al.   NATURE NEUROSCIENCE

Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease

(2008) Zena DeMarch et al.   NEUROBIOLOGY OF DISEASE

RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

(2008) Theresa M. Ballard et al.   PSYCHOPHARMACOLOGY

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

(2008) Olga A. H. Reneerkens et al.   PSYCHOPHARMACOLOGY