Fendiline Inhibits K-Ras Plasma Membrane Localization and Blocks K-Ras Signal Transmission

Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors.

(2017) R. Kefford et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety and efficacy results from the first-in-human study of the oral MEK 1/2 inhibitor GSK1120212.

(2017) J. R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers

(2015) Ryan B. Corcoran et al.   Oncotarget

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Raf Inhibitors Target Ras Spatiotemporal Dynamics

(2012) Kwang-jin Cho et al.   CURRENT BIOLOGY

Nonsteroidal Anti-inflammatory Drugs Alter the Spatiotemporal Organization of Ras Proteins on the Plasma Membrane

(2012) Yong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations

(2012) J. G. Greger et al.   MOLECULAR CANCER THERAPEUTICS

Mutant BRAF Melanomas—Dependence and Resistance

(2011) Poulikos I. Poulikakos et al.   CANCER CELL

A palmitoylation switch mechanism regulates Rac1 function and membrane organization

(2011) Inmaculada Navarro-Lérida et al.   EMBO JOURNAL

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

(2011) Seth A. Wander et al.   JOURNAL OF CLINICAL INVESTIGATION

Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling

(2011) Nikhil Wagle et al.   JOURNAL OF CLINICAL ONCOLOGY

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

(2011) Anchal Chandra et al.   NATURE CELL BIOLOGY

BRAF targeted therapy changes the treatment paradigm in melanoma

(2011) Antoni Ribas et al.   Nature Reviews Clinical Oncology

Resistance to MEK Inhibitors: Should We Co-Target Upstream?

(2011) P. I. Poulikakos et al.   Science Signaling

Multiple Cellular Proteins Modulate the Dynamics of K-ras Association with the Plasma Membrane

(2010) Pinkesh Bhagatji et al.   BIOPHYSICAL JOURNAL

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

The Anti-inflammatory Drug Indomethacin Alters Nanoclustering in Synthetic and Cell Plasma Membranes

(2010) Yong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

(2010) E. W. Joseph et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gatekeeper Mutations Mediate Resistance to BRAF-Targeted Therapies

(2010) S. Whittaker et al.   Science Translational Medicine

Fendiline-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in human oral cancer cells

(2009) CC Huang et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

K-Ras Nanoclustering Is Subverted by Overexpression of the Scaffold Protein Galectin-3

(2008) R. Shalom-Feuerstein et al.   CANCER RESEARCH

Therapeutic strategies for inhibiting oncogenic BRAF signaling

(2008) Ensar Halilovic et al.   CURRENT OPINION IN PHARMACOLOGY

Differential Interference of Chlorpromazine with the Membrane Interactions of Oncogenic K-Ras and Its Effects on Cell Growth

(2008) Sharon Eisenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrostatic Interactions Positively Regulate K-Ras Nanocluster Formation and Function

(2008) S. J. Plowman et al.   MOLECULAR AND CELLULAR BIOLOGY