Article
Neurosciences
Xinran Cheng, Zhenzhen Yan, Zexiong Su, Jie Liu
Summary: This study investigates the function of TIG-2 in Caenorhabditis elegans and reveals its role in modulating synaptogenesis, neurotransmission, and energy metabolism, which in turn regulate the behavioral phenotype of the worms.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yangning Lu, Tosif Ahamed, Ben Mulcahy, Jun Meng, Daniel Witvliet, Sihui Asuka Guan, Douglas Holmyard, Wesley Hung, Quan Wen, Andrew D. Chisholm, Aravinthan D. T. Samuel, Mei Zhen
Summary: In C. elegans, the motor circuit of juvenile stage generates adult-like bending waves with dorsal-ventral symmetry, despite having asymmetric wiring between motor neurons and muscles. This is achieved through the coordination between excitatory and inhibitory motor neurons for dorsal muscle contraction and ventral muscle relaxation, respectively.
Article
Plant Sciences
Mi Ri Kim, Su-Yeon Cho, Hee Ju Lee, Joo Yeon Kim, Uyen Tran Tu Nguyen, Ngoc Minh Ha, Ki Young Choi, Kwang Hyun Cha, Jeong-Ho Kim, Won Kyu Kim, Kyungsu Kang
Summary: Schisandrin C improves intestinal barrier formation and permeability dysfunction by regulating TJ protein expression and signaling pathways. This study is important for understanding the mechanisms of intestinal inflammation and permeability disorders and exploring new therapeutic approaches.
Editorial Material
Biochemistry & Molecular Biology
Patrick J. Hu
Summary: The study in C. elegans model showed that a conserved insulin-like signaling pathway plays an important role in shaping the phylogenetic composition of the gut microbiome.
Editorial Material
Biochemistry & Molecular Biology
Erin J. Cram
Summary: Cells release extracellular vesicles containing proteins, lipids, and RNAs to communicate with other cells and remove damaged components. In C. elegans, neuronal cells release large extracellular vesicles called exophers to clear damaged organelles and protein aggregates. Researchers have now shown that embryos in the uterus can stimulate body wall muscle cells to release exophers loaded with yolk, which are then absorbed by oocytes to nourish the next generation of embryos.
Article
Biochemistry & Molecular Biology
V Cilleros-Mane, L. Just-Borras, A. Polishchuk, M. Duran, M. Tomas, N. Garcia, J. M. Tomas, M. A. Lanuza
Summary: The study reveals how M-1 and M-2 mAChR regulate PKC beta I and epsilon isoforms, influencing the mechanism of neurotransmitter release. M-1 activates PDK1 to promote phosphorylation of PKC beta I and epsilon, while M-2 inhibits the synthesis of PKC epsilon through a PKA-dependent pathway.
Article
Biology
Xinwei Yu, Matthew S. Creamer, Francesco Randi, Anuj K. Sharma, Scott W. Linderman, Andrew M. Leifer
Summary: A method called fDNC, based on the transformer network architecture, is proposed for automated tracking and identifying neurons in C. elegans. This method predicts neural correspondence quickly without requiring straightening or transforming the animal into a canonical coordinate system, making it suitable for future real-time applications.
Article
Biochemistry & Molecular Biology
Maoxuan Liu, Jing-Guang Lu, Ming-Rong Yang, Zhi-Hong Jiang, Xiaochun Wan, Walter Luyten
Summary: This study aimed to identify the anthelmintic compounds in Semen pharbitidis and explore their mechanism of action. The results showed that pharbitin, a glycoside found in Semen pharbitidis, has anthelmintic activity and its target may be UNC-63 in C. elegans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Julia Zwirchmayr, Cristina D. Cruz, Ulrike Grienke, Paeivi Tammela, Judith M. Rollinger
Summary: The root extract of Peucedanum ostruthium (PO-E) was found to be a promising antibacterial source against Staphylococcus aureus. It was also shown to significantly decrease the survival of Caenorhabditis elegans. Through the biochemometric approach ELINA, the anti-infective constituent(s) targeting S. aureus and C. elegans in the multicomponent mixture PO-E were identified.
Article
Multidisciplinary Sciences
Hillary A. Miller, Shijiao Huang, Elizabeth S. Dean, Megan L. Schaller, Angela M. Tuckowski, Allyson S. Munneke, Safa Beydoun, Scott D. Pletcher, Scott F. Leiser
Summary: This study found that mimicking dietary restriction by blocking food odor signaling can extend lifespan. Serotonin and dopamine were identified as playing a role in limiting lifespan in response to food odor. The study revealed the involvement of a neural network in dietary perception.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Adel E. E. Khairullin, Sergey N. N. Grishin, Ayrat U. U. Ziganshin
Summary: The purine signaling system, represented by purine and pyrimidine nucleotides and nucleosides, plays a role through the adenosine, P2X and P2Y receptor families. While P2 receptors have a minor role in physiological conditions, they become more significant in certain pathophysiological conditions, functioning as dominant signaling molecules. The diversity and distribution of P2 receptors make them an attractive target for new mechanism drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ellya A. Bukharaeva, Andrey Skorinkin, Dmitry Samigullin, Alexey M. Petrov
Summary: Effective transmission of excitation in neuromuscular junctions requires a certain level of depolarization to trigger action potential spreading. The amplitude of end-plate potential, which depends on the synchronization and release rate of acetylcholine quanta, is influenced by presynaptic autoreceptors. The timing characteristics of neurotransmitter release play a crucial role in the plasticity and efficacy of synaptic transmission.
Article
Biochemistry & Molecular Biology
Elena Petukhova, Daria Ponomareva, Karin Rustler, Burkhard Koenig, Piotr Bregestovski
Summary: In this study, it was found that Glyght can modulate GABAergic synaptic transmission by acting on extrasynaptic glycine receptors, without affecting postsynaptic GABA receptors and neurotransmitter release mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Wenli Zhang, Wenhua Li, Jiangyan Li, Xiaoru Chang, Shuyan Niu, Tianshu Wu, Lu Kong, Ting Zhang, Meng Tang, Yuying Xue
Summary: This study found that exposure to AgNPs can impact the survival, neurobehavior, and sensory perception of Caenorhabditis elegans, particularly affecting dopaminergic, GABAergic, and cholinergic neurons. Low doses of AgNPs exposure may increase receptors of GABAergic and dopamine in C. elegans, while higher doses show opposite results.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
James J. Doyle, Claudia Maios, Celine Vrancx, Sarah Duhaime, Babykumari Chitramuthu, Hugh P. J. Bennett, Andrew Bateman, J. Alex Parker
Summary: The article discusses the link between GRN mutations and frontotemporal dementia (FTD) discovered in 2006 and highlights the need for advancing genetic and small-molecule therapeutics for GRN-related FTD. Research using the nematode model, Caenorhabditis elegans, shows that loss of nematode GRN ortholog results in behavioral and molecular defects, and implicates the sphingolipid metabolic pathway in regulating these defects. High-throughput drug screening using nematodes has identified two small molecules with potential therapeutic applications against GRN/pgrn-1 deficiency, offering avenues for mechanistic and therapeutic research into GRN-related neurodegeneration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Ruta B. Almedom, Jana F. Liewald, Guillermina Hernando, Christian Schultheis, Diego Rayes, Jie Pan, Thorsten Schedletzky, Harald Hutter, Cecilia Bouzat, Alexander Gottschalk
Article
Biochemistry & Molecular Biology
Andrew K. Jones, Diego Rayes, Adam Al-Diwani, Thomas P. R. Maynard, Rachel Jones, Guillermina Hernando, Steven D. Buckingham, Cecilia Bouzat, David B. Sattelle
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Pharmacology & Pharmacy
Ornella Turani, Guillermina Hernando, Jeremias Corradi, Cecilia Bouzat
MOLECULAR PHARMACOLOGY
(2018)
Article
Infectious Diseases
Guillermina Hernando, Ornella Turani, Cecilia Bouzat
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Biochemistry & Molecular Biology
Noelia Rodriguez Araujo, Guillermina Hernando, Jeremias Corradi, Cecilia Bouzat
Summary: This study reveals the potential compounds regulating the function of MOD-1 and demonstrates its role in worm locomotion, suggesting MOD-1 as a potential target for anthelmintic therapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Juan Facundo Chrestia, Ornella Turani, Noelia Rodriguez Araujo, Guillermina Hernando, Maria del Carmen Esandi, Cecilia Bouzat
Summary: Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the central and peripheral nervous system and play crucial roles in vital physiological processes. Post-translational modifications (PTMs) have been shown to regulate different aspects of nAChR life cycle, but our knowledge in this field is still limited and many important aspects remain unknown.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Guillermina Hernando, Ignacio Berge, Diego Rayes, Cecilia Bouzat
MOLECULAR PHARMACOLOGY
(2012)
Article
Pharmacology & Pharmacy
Diego Rayes, Marina Flamini, Guillermina Hernando, Cecilia Bouzat
MOLECULAR PHARMACOLOGY
(2007)