Differential Effects of CSF-1R D802V and KIT D816V Homologous Mutations on Receptor Tertiary Structure and Allosteric Communication

Allosteric pathway identification through network analysis: from molecular dynamics simulations to interactive 2D and 3D graphs

(2014) Ariane Allain et al.   FARADAY DISCUSSIONS

Systemic mastocytosis in adults: 2013 update on diagnosis, risk stratification, and management

(2013) Animesh Pardanani   AMERICAN JOURNAL OF HEMATOLOGY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Macrophage Proliferation Is Regulated through CSF-1 Receptor Tyrosines 544, 559, and 807

(2012) Wenfeng Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia

(2012) R Swords et al.   LEUKEMIA

c-Fms Signaling Mediates Neurofibromatosis Type-1 Osteoclast Gain-In-Functions

(2012) Yongzheng He et al.   PLoS One

Allosteric Communication across the Native and Mutated KIT Receptor Tyrosine Kinase

(2012) Elodie Laine et al.   PLoS Computational Biology

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

Detection of allosteric signal transmission by information-theoretic analysis of protein dynamics

(2011) Alessandro Pandini et al.   FASEB JOURNAL

Molecular dynamics simulation reveals structural and thermodynamic features of kinase activation by cancer mutations within the epidermal growth factor receptor

(2011) Shunzhou Wan et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS

Mutation D816V Alters the Internal Structure and Dynamics of c-KIT Receptor Cytoplasmic Region: Implications for Dimerization and Activation Mechanisms

(2011) Elodie Laine et al.   PLoS Computational Biology

Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode

(2010) Marvin J. Meyers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Consensus modes, a robust description of protein collective motions from multiple-minima normal mode analysis—application to the HIV-1 protease

(2010) Paulo Ricardo Batista et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Invasion of Human Breast Cancer Cells In vivo Requires Both Paracrine and Autocrine Loops Involving the Colony-Stimulating Factor-1 Receptor

(2009) A. Patsialou et al.   CANCER RESEARCH

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

(2009) K. S. Gajiwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A generic method for assignment of reliability scores applied to solvent accessibility predictions

(2009) Bent Petersen et al.   BMC STRUCTURAL BIOLOGY

Coupling between global dynamics and signal transduction pathways: a mechanism of allostery for chaperonin GroEL

(2008) Chakra Chennubhotla et al.   Molecular BioSystems

The Jpred 3 secondary structure prediction server

(2008) C. Cole et al.   NUCLEIC ACIDS RESEARCH

P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation

(2007) Berk Hess   Journal of Chemical Theory and Computation