CRISPR/Cas9 Allows Efficient and Complete Knock-In of a Destabilization Domain-Tagged Essential Protein in a Human Cell Line, Allowing Rapid Knockdown of Protein Function

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases

(2013) S. W. Cho et al.   GENOME RESEARCH

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

(2013) Prashant Mali et al.   NATURE BIOTECHNOLOGY

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

(2013) Vikram Pattanayak et al.   NATURE BIOTECHNOLOGY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion

(2013) Matthew A Child et al.   Nature Chemical Biology

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

(2013) Thomas J. Cradick et al.   NUCLEIC ACIDS RESEARCH

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Gross deletions in TCOF1 are a cause of Treacher–Collins–Franceschetti syndrome

(2012) Michael Bowman et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Destabilizing Domains Derived from the Human Estrogen Receptor

(2012) Yusuke Miyazaki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intracellular Context Affects Levels of a Chemically Dependent Destabilizing Domain

(2012) Mark A. Sellmyer et al.   PLoS One

Systematic Analysis of FKBP Inducible Degradation Domain Tagging Strategies for the Human Malaria Parasite Plasmodium falciparum

(2012) Mauro Ferreira de Azevedo et al.   PLoS One

Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells

(2012) Daisuke Sakai et al.   PLoS Genetics

Ligand-switchable Substrates for a Ubiquitin-Proteasome System

(2011) Emily L. Egeler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice

(2011) Jin Hee Kim et al.   PLoS One

A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

(2010) Mari Iwamoto et al.   CHEMISTRY & BIOLOGY

Treacle recruits RNA polymerase I complex to the nucleolus that is independent of UBF

(2009) Chen-I Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

Treacher Collins syndrome: etiology, pathogenesis and prevention

(2008) Paul A Trainor et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Treacher Collins syndrome: Unmasking the role of Tcof1/treacle

(2008) Daisuke Sakai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY