Guanabenz Interferes with ER Stress and Exerts Protective Effects in Cardiac Myocytes

Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention

(2012) Pavel Tsaytler et al.   FEBS Journal

Cardioprotective Effect of 3-Iodothyronamine in Perfused Rat Heart Subjected to Ischemia and Reperfusion

(2011) Sabina Frascarelli et al.   CARDIOVASCULAR DRUGS AND THERAPY

Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy

(2011) Nicolas Barbezier et al.   EMBO Molecular Medicine

Thapsigargin triggers cardiac contractile dysfunction via NADPH oxidase-mediated mitochondrial dysfunction: Role of Akt dephosphorylation

(2011) Yingmei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

Ablation of C/EBP Homologous Protein Attenuates Endoplasmic Reticulum–Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload

(2010) Hai Ying Fu et al.   CIRCULATION

What Is the Role of ER Stress in the Heart?

(2010) Masafumi Kitakaze et al.   CIRCULATION RESEARCH

Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease

(2010) Tetsuo Minamino et al.   CIRCULATION RESEARCH

Development of a Drug Screening Platform Based on Engineered Heart Tissue

(2010) Arne Hansen et al.   CIRCULATION RESEARCH

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

(2009) Yi-Wei Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands

(2009) Liaoyuan A. Hu et al.   BIOCHEMICAL JOURNAL

Modulation of cardiac ionic homeostasis by 3-iodothyronamine

(2009) Sandra Ghelardoni et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ER stress in cardiovascular disease

(2009) Tetsuo Minamino et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

(2009) Heather P. Harding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy

(2008) Ali El-Armouche et al.   CARDIOVASCULAR RESEARCH

How IRE1 Reacts to ER Stress

(2008) David Ron et al.   CELL

A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death

(2008) M Boyce et al.   CELL DEATH AND DIFFERENTIATION

Guanabenz, an α2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells

(2008) Caroline Norez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cardiac effects of trace amines: Pharmacological characterization of trace amine-associated receptors

(2008) Sabina Frascarelli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1

(2008) InKi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

(2008) Liping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian Prions

(2008) Déborah Tribouillard-Tanvier et al.   PLoS One

A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress

(2007) Dan Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS