Article
Oncology
Jiechao Yang, Qiang Huang, Yang Guo, Zheqiang Wei, Liang Zhou, Hui Chen
Summary: DIAPH1 is a protein closely related to cell cycle and mitosis, with its expression affecting overall survival in patients with laryngeal squamous cell carcinoma. It promotes cell proliferation and colony formation, and influences LSCC progression by regulating cell cycle signaling pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huifeng Li, Ying Zhong, Guangxu Cao, Hezhan Shi, Yiyao Liu, Lingfeng Li, Peidi Yin, Jialing Chen, Zhendong Xiao, Bin Du
Summary: This study identifies the crucial roles of METTL3 and CDC25B in cell cycle regulation, and reveals the significance of the METTL3/m(6)A/CDC25B pathway in the cell cycle.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Yingji Chen, Ying Ji, Suo Liu, Yicai Liu, Wei Feng, Longyu Jin
Summary: PTBP3 is overexpressed in LUSC tissues and its high expression is significantly correlated with poor prognosis. PTBP3 knockdown results in decreased cell proliferation rate. Bioinformatics analysis reveals that PTBP3 is involved in cell cycle regulation in LUSC.
CANCER CELL INTERNATIONAL
(2022)
Article
Clinical Neurology
Christine A. Eckhardt, Haoqi Sun, Preeti Malik, Syed Quadri, Marcos Santana Firme, Daniel K. Jones, Meike van Sleuwen, Aayushee Jain, Ziwei Fan, Jin Jing, Wendong Ge, Husain H. Danish, Caron A. Jacobson, Daniel B. Rubin, Eyal Y. Kimchi, Sydney S. Cash, Matthew J. Frigault, Jong Woo Lee, Jorg Dietrich, M. Brandon Westover
Summary: This study developed an automated, physiologic metric, known as the EEG immune effector cell-associated neurotoxicity syndrome score, to detect the presence and severity of neurotoxicity among patients undergoing chimeric antigen receptor-T cell therapy. The score showed high criterion, construct, and predictive validity, making it a reliable method for assessing neurotoxicity in these patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Oncology
Yang Yao, Chao Liu, Bojun Wang, Xin Guan, Lin Fang, Fei Zhan, Haoxiu Sun, Hengzhen Li, Changjie Lou, Feihu Yan, Xiaolin Lu, Luying Cui, Yuanyu Liao, Shuling Han, Yuanfei Yao, Yanqiao Zhang
Summary: In pancreatic cancer, the expression of HOXB9 is down-regulated, while higher expression of HOXB9 is associated with higher survival rates. Over-expression of HOXB9 inhibits pancreatic cancer cell proliferation by regulating RBL2 and cMyc to block cell cycle progression. DNMT1 in pancreatic cancer inhibits the expression of HOXB9 through methylation of its promoter.
Article
Oncology
Jiaqi Sun, Xiyang Wang, Qingsong Shen, Min Wang, Shuxian Chen, Xuechun Zhang, Yongping Huang, Zhonglin Zhang, Wenhua Li, Yufeng Yuan, Zan Huang
Summary: DNASE1L3 is a novel HCC cell cycle regulator and tumor suppressor that impairs HCC tumorigenesis by delaying cell cycle progression, possibly through disrupting the positive E2F1-CDK2 regulatory loop. DNASE1L3 may serve as a target for the development of novel therapeutic strategies against HCC.
Article
Pharmacology & Pharmacy
Tingting Zhang, Hui Liu, Min Liu, Chunhong Wang
Summary: Farrerol inhibited the viability, proliferation, cell cycle progression, migration, and invasion, but promoted apoptosis, ROS formation intensity, and disruption of MMP in LSCC cells. Additionally, Farrerol up-regulated Cyt C, Cleaved caspase-3/9, and E-cadherin levels, while down-regulating Cyclin D1, N-cadherin, and Vimentin levels in LSCC cells, suggesting that Farrerol suppressed migration and invasion and induced apoptosis in LSCC cells through the mitochondria-mediated pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Qiuming He, Zheyu Ding, Tingna Chen, Haitao Wu, Jialing Song, Zhenxian Xiang, Chaogang Yang, Shuyi Wang, Bin Xiong
Summary: Gastric cancer is a global health burden with limited understanding and poor prognosis. In this study, we identified PFDN2 as a key gene in gastric cancer and found that its upregulation is associated with cancer progression. Further investigations revealed that PFDN2 promotes cell cycle progression by facilitating the expression of MYBL2 through the nuclear translocation of hnRNPD. These findings suggest that PFDN2 may serve as a potential biomarker and therapeutic target for gastric cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Baozhi Song, Yatao Jiang, Yu Jiang, Ying Lin, Jiahua Liu
Summary: The study indicates that ML323 is an effective anti-ovarian cancer drug that inhibits the proliferation of OV cells by targeting the USP1-regulated cell cycle.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Tao Ma, Yan Chen, Zhi-Gang Yi, Jia Liu, Yan-Hong Li, Jun Bai, Wen-Ting Tie, Mei Huang, Xiao-Feng Zhu, Ji Wang, Juan Du, Xiu-Qin Zuo, Qin Li, Fan-Li Lin, Liu Tang, Jing Guo, Hong-Wen Xiao, Qian Lei, Xiao-Li Ma, Li-Juan Li, Lian-Sheng Zhang
Summary: This study reveals that NORAD acts as an oncogene in multiple myeloma and exerts its effects through the BMP6/P-ERK1/2 axis. Knockdown of NORAD promotes apoptosis and induces cell cycle arrest, while inhibiting cell proliferation in multiple myeloma.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
H. Gao, Y. Zhang, Y. Li, X. Lin
Summary: Kinesin superfamily proteins (KIFs) are microtubule motor proteins that regulate cell processes through microtubule depolymerization. Downregulation of KIF2A in brown planthopper affects ovarian development by delaying cell cycle progression, reducing nuclear numbers, and impacting cell development and eclosion. This suggests that KIF2A plays a crucial role in regulating ovarian development through cell cycle modulation and/or vitellogenin transportation.
INSECT MOLECULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Luya Pu, Qingyu Meng, Shuai Li, Bin Liu, Fan Li
Summary: Icariin can inhibit the proliferation of FLSs by interfering with the cell cycle process and inducing cell apoptosis, indicating its potential for the treatment of RA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Megan E. Brasch, Alexis N. Pena, James H. Henderson
Summary: In this study, a computational, image analysis-based approach was introduced to accurately identify and characterize distinct functional cell phenotypic subpopulations. Using a heterogeneous model system of endothelial and smooth muscle cells, it was found that cells exhibited different motility rates in co-culture compared to monoculture. This non-destructive and non-invasive imaging method can be broadly applied to heterogeneous cell culture model systems to advance understanding of how heterogeneity affects cell phenotype.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2021)
Article
Environmental Sciences
Hao Luo, Lu Zhai, Weifeng Qiu, Hairong Liang, Lei Yu, Yuan Li, Mengyun Xiong, Jiaying Guo, Huanwen Tang
Summary: The study revealed that the p16/Rb signal pathway is suppressed in hydroquinone-induced malignant transformation of TK6 cells, resulting in enhanced cell proliferation and accelerated cell cycle progression. It was further confirmed that p16 regulates cell cycle progression via Rb and p53, indicating its involvement in hydroquinone-induced malignant transformation.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nathalia Meireles Da Costa, Antonio Palumbo, Marco De Martino, Alfredo Fusco, Luis Felipe Ribeiro Pinto, Luiz Eurico Nasciutti
Summary: The HMGA proteins are aberrantly expressed in several tumors and have been shown to be causative in the carcinogenesis process. The TP53 gene is frequently altered in cancer, with loss of its activity enabling neoplastic transformation. HMGA and p53 proteins may regulate each other's expression or activity, potentially opening up the possibility of targeting them in combination with other therapeutic strategies for better management and prognosis of cancer patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)