Of dogs and men: Comparative biology as a tool for the discovery of novel biomarkers and drug development targets in osteosarcoma

A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group study

(2011) G. Grignani et al.   ANNALS OF ONCOLOGY

Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, includingVEGFA, in human osteosarcoma

(2011) Jilong Yang et al.   CANCER

Frontline treatment of localized osteosarcoma without methotrexate

(2011) Najat C. Daw et al.   CANCER

Height at diagnosis and birth-weight as risk factors for osteosarcoma

(2011) Lisa Mirabello et al.   CANCER CAUSES & CONTROL

Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice

(2011) Grace-Ifeyinwa Onimoe et al.   INVESTIGATIONAL NEW DRUGS

The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model

(2011) Erik R Sampson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

(2011) Ian R. Hardcastle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program

(2011) E. Anders Kolb et al.   PEDIATRIC BLOOD & CANCER

A prognostic evaluation of vascular endothelial growth factor in children and young adults with osteosarcoma

(2011) Iwona Ługowska et al.   PEDIATRIC BLOOD & CANCER

Cytokine-enhanced vaccine and interferon-β plus suicide gene as combined therapy for spontaneous canine sarcomas

(2011) Liliana M.E. Finocchiaro et al.   RESEARCH IN VETERINARY SCIENCE

Effects of lycopene on proliferation and death of canine osteosarcoma cells

(2010) Joseph J. Wakshlag et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor

(2010) Helen J Knowles et al.   BMC CANCER

Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases

(2010) J. M. Atkinson et al.   CANCER RESEARCH

Zoledronic Acid Potentiates mTOR Inhibition and Abolishes the Resistance of Osteosarcoma Cells to RAD001 (Everolimus): Pivotal Role of the Prenylation Process

(2010) G. Moriceau et al.   CANCER RESEARCH

RANK-Fc inhibits malignancy via inhibiting ERK activation and evoking caspase-3-mediated anoikis in human osteosarcoma cells

(2010) Toru Akiyama et al.   CLINICAL & EXPERIMENTAL METASTASIS

A novel locus for canine osteosarcoma (OSA1) maps to CFA34, the canine orthologue of human 3q26

(2010) Jeffrey C. Phillips et al.   GENOMICS

MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src

(2010) Patricia A. Eisenach et al.   JOURNAL OF CELL SCIENCE

Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study

(2010) David Thomas et al.   LANCET ONCOLOGY

Combination of Two Insulin-Like Growth Factor-I Receptor Inhibitory Antibodies Targeting Distinct Epitopes Leads to an Enhanced Antitumor Response

(2010) J. Dong et al.   MOLECULAR CANCER THERAPEUTICS

RANKL expression is related to treatment outcome of patients with localized, high-grade osteosarcoma

(2010) Jun Ah Lee et al.   PEDIATRIC BLOOD & CANCER

Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program

(2010) E. Anders Kolb et al.   PEDIATRIC BLOOD & CANCER

Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program

(2010) Hernan Carol et al.   PEDIATRIC BLOOD & CANCER

Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs

(2010) Melissa C. Paoloni et al.   PLoS One

Characterization of STAT3 activation and expression in canine and human osteosarcoma

(2009) Stacey L Fossey et al.   BMC CANCER

Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression

(2009) Melissa Paoloni et al.   BMC GENOMICS

Inhibitory Effects of VEGF-siRNA Mediated by Adenovirus on Osteosarcoma-Bearing Nude Mice

(2009) You-Shui Gao et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

(2009) Rachael Thomas et al.   CHROMOSOME RESEARCH

Inhibition of Src Phosphorylation Alters Metastatic Potential of Osteosarcoma In vitro but not In vivo

(2009) P. Hingorani et al.   CLINICAL CANCER RESEARCH

Multi-center, Placebo-controlled, Double-blind, Randomized Study of Oral Toceranib Phosphate (SU11654), a Receptor Tyrosine Kinase Inhibitor, for the Treatment of Dogs with Recurrent (Either Local or Distant) Mast Cell Tumor Following Surgical Excision

(2009) C. A. London et al.   CLINICAL CANCER RESEARCH

A meta-analysis on the association of HER-2 overexpression with prognosis in human osteosarcoma

(2009) Y.G. LI et al.   EUROPEAN JOURNAL OF CANCER CARE

HER-2 targeted treatment of osteosarcoma: the challenges of developing targeted therapy and prognostic factors for rare malignancies

(2009) David S Geller et al.   EXPERT OPINION ON PHARMACOTHERAPY

Aerosol Gemcitabine: Preclinical Safety and In Vivo Antitumor Activity in Osteosarcoma-Bearing Dogs

(2009) Carlos O. Rodriguez et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model

(2009) Rashmi Chugh et al.   JOURNAL OF CLINICAL ONCOLOGY

Masitinib is Safe and Effective for the Treatment of Canine Mast Cell Tumors

(2009) K.A. Hahn et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Establishment of a Dog Model for the p53 Family Pathway and Identification of a Novel Isoform of p21 Cyclin-Dependent Kinase Inhibitor

(2009) Jin Zhang et al.   MOLECULAR CANCER RESEARCH

VEGF expression as a prognostic marker in osteosarcoma

(2009) Jyoti Bajpai et al.   PEDIATRIC BLOOD & CANCER

VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma

(2009) Quan Zhou et al.   SURGICAL ONCOLOGY-OXFORD

Expression of Hepatocyte Growth Factor and the Proto-oncogenic Receptor c-Met in Canine Osteosarcoma

(2009) H. Fieten et al.   VETERINARY PATHOLOGY

Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma

(2008) Tadahiko Kubo et al.   CANCER

Copy number gains inEGFRand copy number losses inPTENare common events in osteosarcoma tumors

(2008) Serena S. Freeman et al.   CANCER

Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group

(2008) Paul A. Meyers et al.   JOURNAL OF CLINICAL ONCOLOGY

Serum vascular endothelial growth factor concentrations and postsurgical outcome in dogs with osteosarcoma

(2008) D. H. Thamm et al.   Veterinary and Comparative Oncology

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

(2008) Tim F Cloughesy et al.   PLOS MEDICINE