Article
Chemistry, Multidisciplinary
Minyan Li, Sha Wang, Chunmei Fu, Hongyu Chen, Yuxia Su, Peng Wu, Xinhao Yan, Juanjuan Gao
Summary: Parkinson's disease (PD) is characterized by oxidative stress and this study investigated the neuroprotective effects of salidroside (Sal) on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in PC12 cells. Sal effectively regulated oxidative stress and prevented the transmission of pathologic α-synuclein in the cells. These findings provide insights into potential protective mechanisms against neurodegenerative diseases and synucleinopathies.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Qiu-Xu Chen, Ling Zhou, Tao Long, Da-Lian Qin, Yi-Ling Wang, Yun Ye, Xiao-Gang Zhou, Jian-Ming Wu, An-Guo Wu
Summary: The study shows that galangin has the potential to treat Parkinson's disease by inhibiting neuronal degeneration through activation of the Nrf2/Keap1 signaling pathway and alleviating oxidative damage.
Article
Pharmacology & Pharmacy
Ayaka Sano, Toko Maehara, Ko Fujimori
Summary: This study demonstrates that PGF(2 alpha) can enhance the expression of antioxidant genes through the FP receptor-ERK-Nrf2 signaling pathway, thereby suppressing 6-OHDA-induced neuronal cell death. The findings suggest that the FP receptor may be a potential therapeutic target for ROS-mediated neurodegeneration.
Article
Multidisciplinary Sciences
Rugmani Meenambal, Tomasz Kruk, Jacek Gurgul, Piotr Warszynski, Danuta Jantas
Summary: In this study, PAA-CeO nanoparticles were synthesized and found to have neuroprotective effects against cell damage induced by H2O2 and 6-OHDA, reducing necrotic changes and partially attenuating caspase-3 activity. However, there was no impact on ROS formation induced by H2O2.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Xianwei Gao, Shengnan Li, Xiaofei Liu, Chao Cong, Li Zhao, Huicong Liu, Lianwei Xu
Summary: TGD may attenuate oxidative injury and apoptosis via the Nrf2 and JNK signaling pathways, making it a potential therapeutic candidate for neurodegenerative diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stephanie Cristine Hepp Rehfeldt, Joana Silva, Celso Alves, Susete Pinteus, Rui Pedrosa, Stefan Laufer, Marcia Ines Goettert
Summary: This study evaluated the neuroprotective, antioxidant, and anti-inflammatory activities of luteolin-7-O-glucoside (Lut7). The results suggest that Lut7 has neuroprotective effects and further studies should be conducted to validate its potential in the treatment of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Hao Yu, Xiaojie Liu, Bixuan Chen, Casey R. Vickstrom, Vladislav Friedman, Thomas J. Kelly, Xiaowen Bai, Li Zhao, Cecilia J. Hillard, Qing-Song Liu
Summary: The selective CB2 agonist GW842166x has protective effects against 6-OHDA-induced loss of dopamine neurons and associated motor deficits in mice, potentially through modulation of dopamine neuron firing activity. The neuroprotective effects of GW842166x were prevented by the CB2 receptor antagonist AM630, indicating a CB2-dependent mechanism. Electrophysiological recordings suggest that GW842166x may reduce dopamine neuron vulnerability to 6-OHDA by decreasing action potential firing and associated calcium load.
Article
Biochemistry & Molecular Biology
Inayat Ur Rehman, Amjad Khan, Riaz Ahmad, Kyonghwan Choe, Hyun Young Park, Hyeon Jin Lee, Abubakar Atiq, Jungsung Park, Jong Ryeal Hahm, Myeong Ok Kim
Summary: This study found that nicotinamide exhibits neuroprotective properties in a mouse model of Parkinson's disease, reducing PD-like pathological changes and regulating oxidative stress and neuroinflammation.
Article
Biochemistry & Molecular Biology
Ana Gomes, Sandra M. Monteiro, Carlos Venacio, Luis Felix
Summary: This study investigated the effects of 24-Epibrassinolide (24-EPI) on 6-hydroxydopamine (6-OHDA)-induced toxicity. The results showed that 6-OHDA caused developmental abnormalities and Parkinson's disease-like symptoms in embryos, which were reversed by 24-EPI. These findings support further investigation of the neuroprotective effects of 24-EPI.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Neurosciences
Setthawut Apiraksattayakul, Ratchanok Pingaew, Veda Prachayasittikul, Waralee Ruankham, Papitcha Jongwachirachai, Napat Songtawee, Wilasinee Suwanjang, Tanawut Tantimongcolwat, Supaluk Prachayasittikul, Virapong Prachayasittikul, Kamonrat Phopin
Summary: This study demonstrates that six selected bis-sulfonamide compounds have the potential to act as neuroprotective agents and provide new possibilities for the treatment of Parkinson's disease.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Immunology
Xiyu Gao, Dewei He, Yanting Liu, Mingchi Cui, Zhe Li, Jie Li, Yuan He, Hefei Wang, Bojian Ye, Shoupeng Fu, Dianfeng Liu
Summary: Parkinson's disease is a neurodegenerative disorder that primarily affects middle-aged and elderly individuals. Despite its complex etiology, there is currently no effective treatment. This study found that limonin (LM), a natural compound found in citrus fruits, can ameliorate PD-related damage and symptoms by inhibiting neuronal autophagy and microglial inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Zahra Tayarani-Najaran, Elham Hadipour, Seyed Mahdi Seyed Mousavi, Seyed Ahmad Emami, Leila Mohtashami, Behjat Javadi
Summary: The study demonstrated that Lavandula stoechas methanol extract showed protective effects on 6-hydroxydopamine-induced cytotoxicity and oxidative damage in PC12 cells, indicating its potential as a valuable source of active compounds with neuroprotective, anti-oxidant, and anti-apoptotic properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Changmeng Cui, Changshui Wang, Feng Jin, Mengqi Yang, Lingsheng Kong, Wenxiu Han, Pei Jiang
Summary: The study revealed that calcitriol can alleviate oxidative damage induced by TBI by promoting autophagy and activating Nrf2 signaling. Furthermore, treatment with chloroquine (CQ) and genetic knockout of Nrf2 both eliminated the protective effects of calcitriol against TBI-induced neurological deficits and neuronal apoptosis.
MOLECULAR MEDICINE
(2021)
Article
Immunology
Jing Zhang, Naiwen Zhang, Jianfeng Lei, Bin Jing, Mengyuan Li, Huiling Tian, Bing Xue, Xiaoli Li
Summary: Fluoxetine exhibits neuroprotective effects in relieving LPS-induced depression-like and motor behaviors. The underlying mechanisms may involve inhibiting microglial activation, regulating the Notch signaling pathway, and inhibiting the inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fares E. M. Ali, Emad H. M. Hassanein, Ali H. El-Bahrawy, Mohamed S. Hemeda, Ahmed M. Atwa
Summary: The present study aimed to evaluate the protective effects of lansoprazole on cisplatin-induced cortical intoxication. The results showed that lansoprazole significantly improved cisplatin-induced behavioral changes and histological changes in the cortex. It restored redox balance, enhanced Nrf2/ARE expression, inhibited cisplatin-induced neuronal apoptosis and inflammation, and modulated cortical Akt/p53 signal. This study provides crucial information for developing novel protective strategies to reduce cisplatin cortical toxicity.
JOURNAL OF CHEMICAL NEUROANATOMY
(2023)
Article
Neurosciences
Qiaowen Tong, Weiwei Xiang, Hua Ye, Hehui Zhang, Yiyi Chen, Weian Chen, Chunfeng Liu
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2019)
Article
Cell Biology
Xinyu Zhang, Xianzhi Shen, Jiali Dong, Wen-Cao Liu, Min Song, Yanyun Sun, Hui Shu, Clare-Louise Towse, Wenlan Liu, Chun-Feng Liu, Xinchun Jin
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yunli Yu, Lan Chu, Chunfeng Liu, Mingming Huang, Houfen Wang
EUROPEAN RADIOLOGY
(2019)
Article
Cell Biology
Jian-liang Zhu, Yu-ying Wu, Di Wu, Wei-Feng Luo, Zhi-qing Zhang, Chun-feng Liu
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2019)
Article
Neurosciences
Jing Yang, Dong-Jun Lv, Ling-Xi Li, Ya-Li Wang, Di Qi, Jing Chen, Cheng-Jie Mao, Fen Wang, Yi Liu, Li-Fang Hu, Chun-Feng Liu
Review
Pharmacology & Pharmacy
Chao Ren, Xinxin Gu, Huihua Li, Shihui Lei, Zhe Wang, Jiahui Wang, Peiyuan Yin, Caiyi Zhang, Fen Wang, Chunfeng Liu
PHARMACOLOGICAL RESEARCH
(2019)
Article
Clinical Neurology
Hui-Jun Zhang, Jin-Ru Zhang, Cheng-Jie Mao, Kai Li, Fen Wang, Jing Chen, Chun-Feng Liu
ACTA NEUROLOGICA SCANDINAVICA
(2019)
Article
Neurosciences
Han-Chun Long, Rui Wu, Chun-Feng Liu, Fei-Long Xiong, Zu Xu, Dian He, Yi-Fan Zhang, Bing Shao, Ping-An Zhang, Guang-Yin Xu, Lan Chu
NEUROSCIENCE BULLETIN
(2020)
Article
Chemistry, Multidisciplinary
Fang Wang, Zhe Wang, Fen Wang, Kelly Dong, Jing Zhang, Yun-Juan Sun, Chun-Feng Liu, Mei-Jie Xing, Xue Cheng, Su Wei, Jia-Wei Zheng, Xiong-Fei Zhao, Xiao-Ming Wang, Jie Fu, Hai-Feng Song
ACTA PHARMACOLOGICA SINICA
(2020)
Article
Clinical Neurology
Zhen-Hui Lu, Jia Li, Xin-Ling Li, Mei Ding, Cheng-Jie Mao, Xiang-Yang Zhu, Chun-Feng Liu
EUROPEAN NEUROLOGY
(2020)
Article
Chemistry, Organic
Shengchao Zhou, Yujie Mou, Miao Liu, Qian Du, Basharat Ali, Jurupula Ramprasad, Chunhua Qiao, Li-Fang Hu, Xingyue Ji
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Neurosciences
Hai-Yue Tu, Yong-Quan Gu, Xia Li, Shao-Fang Pei, Li -Fang Hu, Ya-Li Wang
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting dopaminergic neurons. Abnormal autophagy and circadian dysfunction are two characteristics of PD. Blood sample analysis revealed decreased levels of BECN1 and LAMP2 in PD patients, suggesting a potential manifestation of abnormal biological rhythm in PD.
NEUROSCIENCE LETTERS
(2021)
Article
Cell Biology
Hai-Yue Tu, Bao-Shi Yuan, Xiao-Ou Hou, Xiao-Jun Zhang, Chong-Shuang Pei, Ya-Ting Ma, Ya-Ping Yang, Yi Fan, Zheng-Hong Qin, Chun-Feng Liu, Li-Fang Hu
Summary: The extracellular transfer of alpha-Synuclein (alpha-Syn) contributes to Parkinson's disease pathogenesis by activating microglia and neuroinflammation. This study found that extracellular alpha-Syn inhibits microglia autophagy through Toll-like receptor 4 (Tlr4)-mediated p38 and Akt-mTOR signaling pathways, leading to neuroinflammation and PD development.
Article
Biochemistry & Molecular Biology
Xiao-Ou Hou, Hai-Yue Tu, Hai-Chun Qian, Qian Li, Ya-Ping Yang, Guo-Qiang Xu, Fen Wang, Chun-Feng Liu, Ya-Li Wang, Li-Fang Hu
Summary: This study found that exogenous H2S donors can enhance autophagic flux through the AMPK-mTOR signaling pathway, thus reducing the accumulation of alpha-synuclein in dopaminergic cells.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
An-Qi Dong, Ya-Ping Yang, Shu-Min Jiang, Xiao-Yu Yao, Di Qi, Cheng-Jie Mao, Xiao-Yu Cheng, Fen Wang, Li-Fang Hu, Chun-Feng Liu
Summary: This study demonstrates the anti-neuroinflammatory activity of PPX through enhancing autophagy activity in astrocytes, which provides a new mechanism for the beneficial effect of PPX in Parkinson's disease therapy.
ACTA PHARMACOLOGICA SINICA
(2023)