Article
Biochemistry & Molecular Biology
Faiz Ali Khan, Gowhar Ali, Khista Rahman, Yahya Khan, Muhammad Ayaz, Osama F. Mosa, Asif Nawaz, Syed Shams ul Hassan, Simona Bungau
Summary: The study examined the pharmacological potential of a derived flavanone, 2-hydroxyflavanone, as a remedy for pain treatment. The results showed that 2-hydroxyflavanone exhibited considerable analgesic, anti-inflammatory, and anti-neuropathic effects, possibly mediated through opioidergic and GABAergic mechanisms.
Review
Pharmacology & Pharmacy
Mandeep Kaur, Sakshi Misra, Priyanka Swarnkar, Preeti Patel, Balak Das Kurmi, Ghanshyam Das Gupta, Amrita Singh
Summary: Diabetic neuropathy is a common neuro-degenerative disorder affecting peripheral nerves in patients with diabetes, with potential consequences such as sensory loss, discomfort, foot ulceration, and even amputation. The underlying pathophysiology involves multiple signaling pathways, and early detection remains a challenge. Traditional analgesics and opioids are not the first-line treatment, with anticonvulsants and antidepressants being the common approach. Occupational therapy, along with palliative therapy, plays a crucial role in preventing and alleviating neuropathic symptoms, supporting wellness, and preventing disability.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Neurosciences
Piyush Madaan, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Shivam Yadav, Satvinder Kaur, Saurabh Bhatia, Ahmed Al-Harrasi, Ahmed A. H. Abdellatif, Ghulam Md Ashraf, Mohamed M. Abdel-Daim, Hamad Ghaleb Dailah, Md Khalid Anwer, Simona Bungau
Summary: Alcoholic neuropathy is caused by persistent alcohol consumption and leads to nerve damage. Current pharmacotherapy has limited benefits, so research is focusing on finding new targets. This review discusses multiple pathways involved in the development of alcoholic neuropathy, with a particular emphasis on purinergic and orexinergic receptors. Targeting these receptors can help stop the progression of alcoholic neuropathy.
NEUROTOXICITY RESEARCH
(2022)
Article
Cell Biology
Zizhen Wu, Gabor Toro, Guoying Xu, Danny Dang, Charmaine Prater, Qing Yang
Summary: Paclitaxel-induced peripheral neuropathy (PIPN), a common complication in cancer patients undergoing paclitaxel treatment, has no effective therapy currently available. The study found that acute hyperexcitability of primary sensory neurons in PIPN is caused by the inhibition of KCNQ2 potassium channels by paclitaxel. Further experiments demonstrated that administration of KCNQ channel blocker XE-991 induced PIPN-like alterations in rats, while genetic deletion of KCNQ2 in mice attenuated the development of PIPN. These findings provide insights into the pathogenesis of PIPN and may lead to the development of new therapeutic approaches targeting KCNQ channels.
Article
Biochemistry & Molecular Biology
Milena Sleczkowska, Rowida Almomani, Margherita Marchi, Bianca T. A. de Greef, Maurice Sopacua, Janneke G. J. Hoeijmakers, Patrick Lindsey, Erika Salvi, Gidon J. Boenhof, Dan Ziegler, Rayaz A. Malik, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. M. Smeets, Monique M. Gerrits
Summary: Neuropathic pain is common in diabetic peripheral neuropathy (DN), and it may be caused by pathogenic ion channel gene variants. Variants in ion channel genes were found in DN patients with and without pain, suggesting their role in pain generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anesthesiology
Dominic Anthony Friston, Joshua Cuddihy, Jessica Souza Luiz, An Hoai Truong, Laptin Ho, Meirvaan Basra, Peter Santha, Orsolya Oszlacs, Joao de Sousa Valente, Tim Marczylo, Sini Junttila, Helen Laycock, Declan Collins, Marcela Vizcaychipi, Attila Gyenesei, Zoltan Takats, Gabor Jancso, Elizabeth Want, Istvan Nagy
Summary: Tissue injuries, including burns, release intracellular molecules and induce inflammatory reactions, leading to persistent pain. This study reveals that 18:0 LPC, a lysophosphatidylcholine, plays a significant role in burn injury-induced pain. It activates pain-sensing neurons and causes hypersensitivities through the transient receptor potential ion channel. These findings have implications for improving patient care.
Review
Pharmacology & Pharmacy
David Cabanero, Eva Villalba-Riquelme, Gregorio Fernandez-Ballester, Asia Fernandez-Carvajal, Antonio Ferrer-Montiel
Summary: Chronic pain is a significant burden for society, with higher prevalence and severity in females. Transient receptor potential channels (TRP), particularly TRPV1, TRPA1, and TRPM8, play important roles in the perception of hot and cold stimuli and have been extensively studied for their involvement in acute and chronic pain. This review highlights the differential modulation of these channels in males and females, potentially due to sexual hormones, and explores the pharmacology of thermoTRP channels in chronic migraine and chemotherapy-induced peripheral neuropathy. The development of personalized analgesic treatments for chronic pain through targeting these channels represents an important opportunity.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Anesthesiology
Padmamalini Baskaran, Adithya Mohandass, Noah Gustafson, Jane Bennis, Somaja Louis, Brenda Alexander, Mikhail I. Nemenov, Baskaran Thyagarajan, Louis S. Premkumar
Summary: Painful diabetic peripheral neuropathy (PDPN) is a major complication of diabetes. Current treatment options have limitations, such as adverse effects and ineffectiveness. Recent research suggests that targeting the TRPV1 receptor in peripheral sensory nerve terminals may be an effective approach for treating PDPN. In this study, the researchers found that a topical formulation of an ultrapotent TRPV1 agonist called resiniferatoxin (RTX-cream) effectively relieved pain associated with diabetic peripheral neuropathy in animal models. The RTX-cream worked by blocking nerve depolarization in the short term and desensitizing/depleting nerve terminals in the long term, providing long-lasting pain relief without adverse effects.
Article
Chemistry, Medicinal
Laura Micheli, Jagan Rajamoni, Lorenzo Di Cesare Mannelli, Parthasarathi Rajagopalan, Carla Ghelardini, Raghavan Rajagopalan
Summary: Diabetic neuropathy is a common chronic disease, and current medications can only alleviate pain without repairing nerve damage. The study suggests that DDD-028 may be used as a disease modifying therapeutic for the treatment of diabetic neuropathy.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Nursing
Monica A. Wagner, Ellen M. Lavoie Smith, Naji Ayyash, Josue Toledo, Zainab Rasheed, Janean E. Holden
Summary: This study aimed to examine the preventive effects of Duloxetine on oxaliplatin-induced peripheral neuropathy. The findings showed significant preventive effects of Duloxetine on mechanical allodynia and hyperalgesia in both female and male rats.
BIOLOGICAL RESEARCH FOR NURSING
(2023)
Article
Neurosciences
Wuping Sun, Yue Hao, Rongzhen Li, Idy Hiu Ting Ho, Songbin Wu, Nan Li, Xiyuan Ba, Jie Wang, Donglin Xiong, Changyu Jiang, Lizu Xiao, Xiaodong Liu
Summary: Peripheral neuropathy is a common side effect of anticancer therapy. This study compared the transcriptomes of dorsal root ganglia to explore the similar and differential causes of oxaliplatin- and paclitaxel-induced neuropathy. The results showed that both oxaliplatin and paclitaxel treatments caused mechanical and thermal hypersensitivity, but oxaliplatin primarily affected dividing cells and neuroinflammation, while paclitaxel might directly affect somatosensory neurons.
Review
Endocrinology & Metabolism
Shivangi Patel, Arnika Pangarkar, Sakshi Mahajan, Anuradha Majumdar
Summary: Endoplasmic stress response, the unfolded protein response (UPR), is a homeostatic signaling pathway that can be activated in various disease states. Diabetic peripheral neuropathy (DPN), a complication of diabetes, is characterized by chronic pain and loss of sensation. Targeting UPR pathways through synthetic and natural inhibitors may provide effective therapeutic alternatives for DPN.
METABOLIC BRAIN DISEASE
(2023)
Article
Endocrinology & Metabolism
Erika A. Petersen, Thomas G. Stauss, James A. Scowcroft, Michael J. Jaasma, Elizabeth S. Brooks, Deborah R. Edgar, Judith L. White, Shawn M. Sills, Kasra Amirdelfan, Maged N. Guirguis, Jijun Xu, Cong Yu, Ali Nairizi, Denis G. Patterson, Kostandinos C. Tsoulfas, Michael J. Creamer, Vincent Galan, Richard H. Bundschu, Neel D. Mehta, Dawood Sayed, Shivanand P. Lad, David J. Dibenedetto, Khalid A. Sethi, Johnathan H. Goree, Matthew T. Bennett, Nathan J. Harrison, Atef F. Israelc, Paul Chang, Paul W. Wu, Charles E. Argoff, Christian E. Nasr, Rod S. Taylor, David L. Caraway, Nagy A. Mekhail
Summary: A study evaluated the long-term efficacy of high-frequency (10 kHz) spinal cord stimulation (SCS) in treating refractory painful diabetic neuropathy (PDN). The results showed that over 24 months, 10 kHz SCS provided significant pain relief, improved quality of life and sleep, and showed neurological improvement in the majority of participants.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Neurosciences
Ryosuke Shinouchi, Akiko Sasaki, Takashi Takaki, Mayumi Tsuji, Yuji Kiuchi, Koji Nobe
Summary: Hand therapy involving finger massage improves numbness in chemotherapy-induced peripheral neuropathy (CIPN) by promoting blood circulation and facilitating peripheral nerve repair.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Wuping Sun, Shaomin Yang, Songbin Wu, Xiyuan Ba, Donglin Xiong, Lizu Xiao, Yue Hao
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side-effect of anti-cancer therapy. The exact pathogenesis of CIPN is still unclear, and there are no effective analgesics for prevention and treatment. In this study, a paclitaxel-induced peripheral neuropathy (PIPN) model was used to investigate the transcriptomic level of DRG neurons in rats with PIPN. RNAseq analysis identified differentially expressed genes (DEGs) related to neuroactive ligand-receptor interaction, cytokine-cytokine receptor interaction, defense response, and inflammatory response. The study also found shared characteristics of PIPN with inflammatory pain and neuropathic pain.
Article
Anesthesiology
Dina Vasovic, Branka Divovic, Marco Treven, Daniel E. Knutson, Friederike Steudle, Petra Scholze, Aleksandar Obradovic, Jure Fabjan, Bozidar Brkovic, Werner Sieghart, Margot Ernst, James M. Cook, Miroslav M. Savic
EUROPEAN JOURNAL OF PAIN
(2019)
Article
Surgery
Youngsuk Kwon, Sung Mi Hwang, Ji Su Jang, Byoung Yoon Ryu, Byung Yong Kang, Sang Soo Kang, Jae Jun Lee
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
(2019)
Article
Medicine, General & Internal
Young Suk Kwon, Ji Su Jang, Sung Mi Hwang, Hyunjin Tark, Jong Ho Kim, Jae Jun Lee
Article
Anesthesiology
Jong Ho Kim, Young Joon Kim, Ji Su Jang, Sung Mi Hwang
REVISTA BRASILEIRA DE ANESTESIOLOGIA
(2019)
Article
Orthopedics
Jung-Taek Hwang, Ji Su Jang, Jae Jun Lee, Dong-Keun Song, Han Na Lee, Do-Young Kim, Sang-Soo Lee, Sung Mi Hwang, Yong-Been Kim, Sanghyeon Lee
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2020)
Article
Medicine, General & Internal
Ji Su Jang, Youngsuk Kwon, Sung Mi Hwang, Jae Jun Lee, Jun Suck Lee, Soo Kyoung Lee, Ho Seok Lee
Article
Orthopedics
Jae Jun Lee, Do-Young Kim, Jung-Taek Hwang, Dong-Keun Song, Han Na Lee, Ji Su Jang, Sang-Soo Lee, Sung Mi Hwang, Sung Hoon Moon, Jae-Hoon Shim
Summary: The combination of dexmedetomidine with SSNB and ANB resulted in significantly lower pain scores and higher satisfaction scores within 48 hours after arthroscopic rotator cuff repair compared to SSNB and ANB alone. Additionally, the use of dexmedetomidine tended to delay the onset of rebound pain and led to significant changes in cytokine levels postoperatively.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Anesthesiology
Youngsuk Kwon, Jong Ho Kim, Juhyun Yoon, Jaehyun Park, Sang Soo Kang, Sung Mi Hwang
Summary: The study analyzed the effectiveness of insulin treatment for hyperkalemia during anesthesia, revealing that patients with a low estimated glomerular filtration rate had a higher incidence of hyperkalemia not decreasing after insulin treatment. Therefore, periodic assessment of potassium levels may be necessary during anesthesia.
JOURNAL OF ANESTHESIA
(2021)
Article
Anesthesiology
Jong Ho Kim, Haewon Kim, Ji Su Jang, Sung Mi Hwang, So Young Lim, Jae Jun Lee, Young Suk Kwon
Summary: The study developed a model using machine learning to predict difficult laryngoscopy by incorporating factors such as neck circumference and thyromental height. Random forest algorithm demonstrated the best performance, and future improvements in predictive capability can be achieved through more data and model enhancements.
BMC ANESTHESIOLOGY
(2021)
Article
Anesthesiology
Bo-Young Hwang, Jae-Hyun Park, Ho-Tae Ji, Go-Eun Kim, Sun-Key Kim, Yoon-Kyung Lee, Sung-Mi Hwang, Sang-Soo Kang
Summary: This study retrospectively observed the anatomic relationship between DS1F and VS1F through CT analysis and prospectively determined the optimal angle for performing S1-TFESI. The success rate of S1-TFESI with an ipsilateral 25 degrees-tunnel view technique was 100%.
Article
Medicine, General & Internal
Young-Suk Kwon, Haewon Kim, Hanna Lee, Jong-Ho Kim, Ji-Su Jang, Sung-Mi Hwang, Ji-Young Hong, Go-Eun Yang, Youngmi Kim, Jae-Jun Lee
Summary: The increase in red blood cell transfusion after surgery is associated with a higher risk of postoperative pulmonary edema and pulmonary edema with hypoxemia. This increase can be considered as a risk factor for developing pulmonary edema.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Jong Ho Kim, Haewon Kim, Kookhyun Yoo, Sung Mi Hwang, So Young Lim, Jae Jun Lee, Young Suk Kwon
Summary: This study found that there were differences in intraoperative invasive monitoring and use of vasopressor or inotrope among different ASA physical status classifications. Patients with a physical status classification of 3 or higher had a lower risk of postoperative nausea and vomiting compared to those with a classification of 1-2.
PERIOPERATIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Jong-Ho Kim, Bo-Reum Cheon, Min-Guan Kim, Sung-Mi Hwang, So-Young Lim, Jae-Jun Lee, Young-Suk Kwon
Summary: This study employs machine learning to predict postoperative pulmonary complications (PPCs) and identify important features of the prediction models. The dataset collected from two hospitals includes perioperative variables. Various algorithms were used for model development and evaluation. The study enrolled 111,212 adult patients, with an overall incidence rate of 8.6% for developing PPCs. The models achieved AUROC of 0.699-0.767 and f1 score of 0.446-0.526. Ten important features were obtained in the prediction models, except for multilayer perceptron. In feature-reduced models with 10 important features, the AUROC was 0.627-0.749 and the f1 score was 0.365-0.485. The number of packed red cells, urine, and rocuronium doses were similar in the three models.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Jong-Ho Kim, Bo-Reum Cheon, Min-Guan Kim, Sung-Mi Hwang, So-Young Lim, Jae-Jun Lee, Young-Suk Kwon
Summary: This study utilized machine learning to predict PONV and provided valuable insights, finding opioids to be the most important feature associated with patient-controlled analgesia.
BIOENGINEERING-BASEL
(2023)
Article
Medicine, General & Internal
Young-Suk Kwon, Jong-Ho Kim, Sung-Mi Hwang, Jae-Wang Choi, Sang-Soo Kang
Summary: This study compared the incidence of postoperative catheter-related bladder discomfort (CRBD) between sugammadex and pyridostigmine/glycopyrrolate treatments for reversing neuromuscular blockade. The results showed that sugammadex had a similar effect on the occurrence of postoperative CRBD compared with pyridostigmine.
MEDICINA-LITHUANIA
(2022)