A Long QT Mutation Substitutes Cholesterol for Phosphatidylinositol-4,5-Bisphosphate in KCNQ1 Channel Regulation
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Title
A Long QT Mutation Substitutes Cholesterol for Phosphatidylinositol-4,5-Bisphosphate in KCNQ1 Channel Regulation
Authors
Keywords
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Journal
PLoS One
Volume 9, Issue 3, Pages e93255
Publisher
Public Library of Science (PLoS)
Online
2014-03-29
DOI
10.1371/journal.pone.0093255
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Related references
Note: Only part of the references are listed.- Cholesterol regulation of ion channels
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- Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening
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- Intracellular ATP binding is required to activate the slowly activating K+ channel IKs
- (2013) Y. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dual Effect of Phosphatidyl (4,5)-Bisphosphate PIP2on Shaker K+Channels
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- PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker
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- Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2
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- KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity
- (2011) Y. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphatidylinositol-4,5-Bisphosphate (PIP2) Stabilizes the Open Pore Conformation of the Kv11.1 (hERG) Channel
- (2010) Nicolas Rodriguez et al. BIOPHYSICAL JOURNAL
- PKA and PKC partially rescue Long QT type 1 phenotype by restoring channel-PIP2interactions
- (2010) Alessandra Matavel et al. Channels
- Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting
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- Specificity of cholesterol and analogs to modulate BK channels points to direct sterol–channel protein interactions
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- KCNE1-KCNQ1 osmoregulation by interaction of phosphatidylinositol-4,5-bisphosphate with Mg2+and polyamines
- (2010) Julien Piron et al. JOURNAL OF PHYSIOLOGY-LONDON
- Channelopathies linked to plasma membrane phosphoinositides
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- Stoichiometry of the KCNQ1 - KCNE1 ion channel complex
- (2010) K. Nakajo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct Regulation of Prokaryotic Kir Channel by Cholesterol
- (2009) Dev K. Singh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol
- (2009) Y. Epshtein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- I Ks response to protein kinase A-dependent KCNQ1 phosphorylation requires direct interaction with microtubules
- (2008) Céline S. Nicolas et al. CARDIOVASCULAR RESEARCH
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