Review
Chemistry, Multidisciplinary
Seokhwan Chung, Richard A. Revia, Miqin Zhang
Summary: Graphene quantum dots (GQDs) have excellent properties for various applications in nanomedicine. Recent research focuses on their physicochemical, electronic, magnetic, and biological properties, discussing their use in bioimaging and therapy, as well as technical progress in GQDs synthesis.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Wenjie Zhou, Zhe Hu, Jinxin Wei, Hanqing Dai, Yuanyuan Chen, Siyu Liu, Zhongtao Duan, Fengxian Xie, Wanlu Zhang, Ruiqian Guo
Summary: This review summarizes the recent advances in quantum dots-hydrogel composites and their biomedical applications, as well as the challenges in design optimization and future development. The findings of this study provide critical insights and inspiration for future researchers.
CHINESE CHEMICAL LETTERS
(2022)
Article
Materials Science, Multidisciplinary
Yu Ma, Yan Liu, Yurui Wang, Yanzhu Guo, Yuanyuan Li, Ruizhi Li, Xinzi Kong, Qize Han, Rong Wei, Jing Wang
Summary: The study utilized graphene quantum dots as a vehicle to deliver evodiamine, which significantly inhibited the growth of oral squamous cell carcinoma cells in nude mice, providing a new approach for the treatment of OSCC.
MATERIALS & DESIGN
(2022)
Review
Biotechnology & Applied Microbiology
Kaustubh Naik, Shilpi Chaudhary, Lei Ye, Avanish Singh Parmar
Summary: This review introduces the synthesis and properties of carbon quantum dots derived from natural sources, focusing on their applicability as nano-theranostics for the diagnosis and treatment of cancer.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Medicinal
Fernando G. Torres, Karen N. Gonzales, Omar P. Troncoso, Victoria S. Canedo
Summary: The marine environment is a rich source of polysaccharides that can be used to synthesize carbon quantum dots (CQDs). CQDs obtained from marine polysaccharides have unique properties due to the presence of multiple heteroatoms. This review discusses the methods used to synthesize CQDs from different marine polysaccharide sources and highlights their potential applications in various fields.
Review
Chemistry, Multidisciplinary
Yang Liu, Jiaojiao Zheng, Wencai Liu, Zhiqin Yuan, Chao Lu
Summary: This review focuses on the recent advances and applications of steady-state and dynamic bioanalysis based on carbon quantum dots (CQDs) as luminescent probes. The synthesis and luminescence mechanism of CQDs are first introduced, followed by the discussion of sensing principles and tactics in CQD-based luminescent bioanalysis. Steady-state bioanalysis systems and dynamic bioanalysis platforms are discussed, and challenges and future trends are also addressed.
Review
Chemistry, Medicinal
Bhushan Phafat, Sankha Bhattacharya
Summary: The use of quantum technology for drug delivery has the potential to enhance the effectiveness of treatments for rare diseases. Semiconductor nanoparticles known as quantum dots have unique properties that make them suitable for applications as medication carriers and biosensors. Recent advancements in research and clinical domains have enabled in-depth exploration of quantum dots. Notable progress has been made in the fluorescence bioimaging research of quantum dots, where they can be applied for gene transport, drug delivery, and improving the biocompatibility of other medications.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Farzaneh Rasoulzadeh, Mohammad Amjadi
Summary: Highly luminescent water-soluble AgInS2 quantum dots were prepared through a green hydrothermal method, and their chemiluminescence induced by NaIO4 in alkaline solution was investigated. The addition of glutathione effectively enhanced the luminescence intensity, providing a sensing platform for sensitive assay of GSH with a linear range from 1.0 x 10(-9) mol L-1 to 5.0 x 10(-6) mol L-1 and a detection limit of 2.8 x 10(-10) mol L-1, which was successfully applied to the analysis of human plasma for practical use.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Applied
B. N. Kumara, R. Shambhu, Ashwini Prabhu, K. Sudhakara Prasad
Summary: This study reports the design of highly efficient and biocompatible nanocomposites for drug delivery and tracking. A proof-of-concept was demonstrated for the delivery of an anti-glaucoma drug using a novel nanocomposite, with successful drug delivery and intercellular tracking observed. The nanocomposite also showed excellent cell viability and protected cells from oxidative injury.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Youwen Zhang, Gaeun Kim, Yini Zhu, Ceming Wang, Runyao Zhu, Xin Lu, Hsueh-Chia Chang, Yichun Wang
Summary: As nanoscale extracellular vesicles secreted by cells, small extracellular vesicles (sEVs) have great potential as safe and effective drug delivery vehicles. However, there are challenges in loading drugs into sEVs, which hinders their clinical applications. This study presents an exogenous drug-agnostic chiral graphene quantum dots (GQDs) sEV-loading platform, which can efficiently load both hydrophobic and hydrophilic drugs onto GQDs through pi-pi stacking and van der Waals interactions. By optimizing the chirality of the ligands and GQDs, the drug loading efficiency for doxorubicin and siRNA is significantly higher compared to other reported sEV loading techniques.
Article
Nanoscience & Nanotechnology
Chiao-Ling Cheng, Ming-Hsien Chan, Sheng-Jan Feng, Michael Hsiao, Ru-Shi Liu
Summary: The blood-brain barrier is a crucial barrier that protects the brain from external substances. Utilizing nanotechnology and ultrasound induction, this barrier can be temporarily opened for potential brain disease treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Hemlata Kaurav, Dhriti Verma, Amit Bansal, Deepak N. Kapoor, Sandeep Sheth
Summary: Carbon dots (CDs), with particle size less than 10 nm, are carbon-based nanomaterials widely used in various applications such as novel drug delivery for cancer, ocular diseases, infectious diseases, and brain disorders. The biocompatibility, eco-friendliness, ease of synthesis, and low toxicity of CDs, along with their excellent chemical inertness, make them an effective nanocarrier system for delivering multi-functional drugs. This review summarizes the advancements in the past 5 years in utilizing CDs as nanocarriers for gene delivery, vaccine delivery, and antiviral delivery.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Rajesh Kumar, Dinesh Pratap Singh, Romina Munoz, Mongi Amami, Rajesh Kumar Singh, Shipra Singh, Vinod Kumar
Summary: This review article introduces the potential and research progress of graphene and its derivatives in biomedical applications, and summarizes their effects on human health and the environment.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Biochemical Research Methods
Yuan Zhao, Ying Zhang, Huilin Liu, Baoguo Sun
Summary: A chiroptical system based on chiral assembly graphene quantum dots was developed for visual testing of D-phenylalanine, and successfully applied to intracellular chiroptical imaging.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Lin Gong, Ji Sun, Peng Zheng, Yousong Liu, Guangcheng Yang
Summary: A new method was developed for the efficient synthesis of N and Br co-doped GQDs, exhibiting excitation-independent emission properties and high quantum yields, along with excellent cytotoxicity and biological labeling potential.
ACS APPLIED NANO MATERIALS
(2021)
