The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis

Type I Collagen Receptor (α2β1) Signaling Promotes Prostate Cancer Invasion through RhoC GTPase

(2015) Christopher L. Hall et al.   NEOPLASIA

Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle

(2014) Asha Shekaran et al.   BIOMATERIALS

The effect of conditional inactivation of beta 1 integrins using twist 2 Cre, Osterix Cre and osteocalcin Cre lines on skeletal phenotype

(2014) Asha Shekaran et al.   BONE

Bone marrow Th17 TNFα cells induce osteoclast differentiation and link bone destruction to IBD

(2014) Uta Syrbe et al.   GUT

Regulation of Osteoclastogenesis by Integrated Signals From Toll-Like Receptors

(2014) Tamar Krisher et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

M-CSF Priming of Osteoclast Precursors Can Cause Osteoclastogenesis-Insensitivity, Which Can be Prevented and Overcome on Bone

(2014) Teun J. de Vries et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

(2014) M. K. Chang et al.   JOURNAL OF IMMUNOLOGY

βig-h3 Promotes Human Osteosarcoma Cells Metastasis by Interacting with Integrin α2β1 and Activating PI3K Signaling Pathway

(2014) Yun-Shan Guo et al.   PLoS One

Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin

(2014) Rossella Cianci et al.   Journal of Immunology Research

Postmenopausal Osteoporosis: The Role of Immune System Cells

(2013) Maria Felicia Faienza et al.   Clinical & Developmental Immunology

The role of IL-15 in gastrointestinal diseases: A bridge between innate and adaptive immune response

(2013) Danilo Pagliari et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Immune regulation of bone loss by Th17 cells in oestrogen-deficient osteoporosis

(2013) Renqing Zhao   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

 2 1 Integrin Regulates Th17 Cell Activity and Its Neutralization Decreases the Severity of Collagen-Induced Arthritis

(2013) M.-A. El Azreq et al.   JOURNAL OF IMMUNOLOGY

Prevention and treatment of postmenopausal osteoporosis

(2013) Sri Harsha Tella et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Targeting tumor–stromal interactions in bone metastasis

(2013) Mark Esposito et al.   PHARMACOLOGY & THERAPEUTICS

STA-21, a Promising STAT-3 Inhibitor That Reciprocally Regulates Th17 and Treg Cells, Inhibits Osteoclastogenesis in Mice and Humans and Alleviates Autoimmune Inflammation in an Experimental Model of Rheumatoid Arthritis

(2013) Jin-Sil Park et al.   Arthritis & Rheumatology

Definition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation

(2012) S. R. Barthel et al.   CANCER RESEARCH

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

Tissue-Infiltrating Lymphocytes Analysis Reveals Large Modifications of the Duodenal “Immunological Niche” in Coeliac Disease After Gluten-Free Diet

(2012) Rossella Cianci et al.   Clinical and Translational Gastroenterology

Intercellular Cross-Talk Among Bone Cells: New Factors and Pathways

(2012) Natalie A. Sims et al.   Current Osteoporosis Reports

Interleukin-33, a Target of Parathyroid Hormone and Oncostatin M, Increases Osteoblastic Matrix Mineral Deposition and Inhibits Osteoclast Formationin Vitro

(2011) Hasnawati Saleh et al.   ENDOCRINOLOGY

IL-1  and TNF -initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis

(2011) T. Mori et al.   INTERNATIONAL IMMUNOLOGY

T cell-mediated increased osteoclast formation from peripheral blood as a mechanism for crohn's disease-associated bone loss

(2011) Angela E. Oostlander et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Type 17 T-helper cells might be a promising therapeutic target for osteoporosis

(2011) Feng-Lai Yuan et al.   MOLECULAR BIOLOGY REPORTS

Regulation of bone by the adaptive immune system in arthritis

(2011) Kazuo Okamoto et al.   ARTHRITIS RESEARCH & THERAPY

Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation

(2010) Mario M. Zaiss et al.   ARTHRITIS AND RHEUMATISM

The role of interleukin-17 in mediating joint destruction in rheumatoid arthritis

(2010) Xia Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alpha2beta1 integrin is the major collagen-binding integrin expressed on human Th17 cells

(2010) Marc Boisvert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Update in New Anabolic Therapies for Osteoporosis

(2010) Ernesto Canalis   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis

(2010) M. M. Zaiss et al.   JOURNAL OF IMMUNOLOGY

Cellular Mediators of Inflammation: Tregs andTH17Cells in Gastrointestinal Diseases

(2010) Franco Pandolfi et al.   MEDIATORS OF INFLAMMATION

Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures

(2010) P. D’Amelio et al.   OSTEOPOROSIS INTERNATIONAL

A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner

(2009) Leonard Rifas et al.   ARTHRITIS AND RHEUMATISM

PEG-modified biopharmaceuticals

(2009) Pascal Bailon et al.   Expert Opinion on Drug Delivery

Professional Memory CD4+ T Lymphocytes Preferentially Reside and Rest in the Bone Marrow

(2009) Koji Tokoyoda et al.   IMMUNITY

Differentiation and function of pro-inflammatory Th17 cells

(2009) Chen Dong   MICROBES AND INFECTION

Aberrant integrin activation induces p38 MAPK phosphorylation resulting in suppressed Fas-mediated apoptosis in T cells: Implications for rheumatoid arthritis

(2009) Yu-ping Lin et al.   MOLECULAR IMMUNOLOGY

Proinflammatory cytokines and osteoporosis

(2009) Robert R. McLean   Current Osteoporosis Reports

Osteal macrophages: A new twist on coupling during bone dynamics

(2008) Allison R. Pettit et al.   BONE

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

(2008) Ann E. Kearns et al.   ENDOCRINE REVIEWS

Toll-Like Receptor Signaling in Small Intestinal Epithelium Promotes B-Cell Recruitment and IgA Production in Lamina Propria

(2008) Limin Shang et al.   GASTROENTEROLOGY

CD137L- and RANKL-mediated reverse signals inhibit osteoclastogenesis and T lymphocyte proliferation

(2008) Ramamoorthy Senthilkumar et al.   IMMUNOBIOLOGY