Article
Biochemistry & Molecular Biology
Soon-Ae Kim, Jung-Hoon Chai, Eun-Hye Jang
Summary: The study observed gender differences and epigenetic changes in mice exposed to prenatal TMT, with male mice showing more significant behavioral changes and decreased mtDNA copies in specific brain regions. Epigenetic changes, including altered DNA methylation levels, were also identified in the male TMT-exposed hippocampus. Further analysis revealed dysregulation of signaling pathways related to metabolism and neurodevelopment, highlighting the importance of considering sex differences and epigenetics in prenatal toxicology studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Xiangsheng Hong, Rui Chen, Le Zhang, Liang Yan, Jiajing Xin, Jiasu Li, Jinmiao Zha
Summary: This study investigated the long-term neurotoxic effects of residual antidepressant citalopram on zebrafish. The results showed that continuous exposure to citalopram led to decreased motor function, learning, and memory in both larval and adult zebrafish. However, the effects were reversible in larval zebrafish after transferring to a clean medium. The study provides insights into the neurotoxic mechanisms of citalopram and its potential environmental and health risks.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Pediatrics
Elizabeth Yen, Jonathan M. M. Davis
Summary: This article provides a overview of the long-term effects of antenatal opioid exposure on neonates and children, as well as quality improvement and research efforts to address this major public health concern.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Nian Cao, Cong Lan, Caiyu Chen, Zaicheng Xu, Hao Luo, Shuo Zheng, Xue Gong, Hongmei Ren, Zhuxin Li, Shuang Qu, Cheng Yu, Jining Yang, Pedro A. Jose, Yundai Chen, Gengze Wu, Cuimei Hu, Junyi Yu, Chunyu Zeng
Summary: This study found that adverse prenatal exposure induces transgenerational hypertension through an epigenetic-regulated mechanism, and identified potentially preventive and therapeutic strategies for hypertension.
Article
Behavioral Sciences
Natacha M. De Genna, Jennifer A. Willford, Gale A. Richardson
Summary: With the increasing use of cannabis during pregnancy, it is important to understand the developmental effects of prenatal cannabis exposure (PCE). This review discusses methodological considerations and reviews findings from studies on PCE. The results suggest that PCE may have effects on birth weight but not long-term growth. It also has subtle yet enduring effects on memory and achievement, as well as consistent effects on externalizing behaviors that persist into adulthood.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Mohammed H. Sarikahya, Samantha L. Cousineau, Marta De Felice, Hanna J. Szkudlarek, Karen K. W. Wong, Marieka V. DeVuono, Kendrick Lee, Mar Rodriguez-Ruiz, Dana Gummerson, Emma Proud, Tsun Hay Jason Ng, Roger Hudson, Tony Jung, Daniel B. Hardy, Ken K. -C. Yeung, Susanne Schmid, Walter Rushlow, Steven R. Laviolette
Summary: With increasing maternal cannabis use, it is important to investigate the long-term effects of prenatal exposure to THC on cognitive/memory function. This study using a rodent model found that male and female offspring displayed long-term deficits in cognitive domains, but the underlying mechanisms differed between sexes. The ECS and specific PUFA signaling abnormalities in the PFC and hippocampus may contribute to these outcomes.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Ida Siveke, Mike H. Myoga, Benedikt Grothe, Felix Felmy
Summary: Research shows that during moderate omnidirectional noise exposure, the input resistance of neurons in the medial superior olive decreases, while the action potential current threshold increases, leading to more efficient high frequency output generation. Noise exposure also accelerates the occurrence of spontaneous postsynaptic currents.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Le Zhou, Xinghui Liu, Xiaoli Yan, Yingwei Liu, Yao Xie, Chuntang Sun
Summary: This study used structural MRI to analyze the changes in gray matter volume in preterm-born and term-born children, and showed that the intelligence scores of preterm-born children without magnesium sulfate treatment were significantly lower than those of term-born children, while the scores of preterm-born children with magnesium sulfate treatment were almost identical to those of term-born children.
FOOD SCIENCE & NUTRITION
(2023)
Article
Environmental Sciences
Ming Pan, Zi-Wei Cheng, Chen-Guang Huang, Zhu-Qing Ye, Li-Jun Sun, Hua Chen, Bei-Bei Fu, Kai Zhou, Zhi-Rui Fang, Zi-Jian Wang, Qing-Zhong Xiao, Xue-Sheng Liu, Feng-Qin Zhu, Shan Gao
Summary: This study investigated the role of excessive copper accumulation in mitochondrial damage and cell apoptosis inhibition in the heart. The results showed that copper accumulation leads to mitochondrial injury and apoptosis, resulting in heart damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Environmental Sciences
Xiao-Xia Chen, Yan-Ming Xu, Andy T. Y. Lau
Summary: This review examines the changes in metabolic profiles of humans and rodents under long-term cadmium exposure and discusses the relationship between the disturbance of metabolic pathways and the toxic mechanism of cadmium. This information is useful for the development of reliable metabolic biomarkers for early detection and diagnosis of cadmium-related diseases.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Joan Barcelo
Summary: Exposure to war has long-term effects on civic engagement, with evidence from the Vietnam War showing that residents in heavily affected areas were more engaged in social organizations 26 years later. Mechanisms of persistence include both individual-level and community-wide transmission.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Multidisciplinary
Serhat Hizlisoy, Serdar Yildirim, Zekeriya Tufekci
Summary: An approach for music emotion recognition based on CLDNN architecture is proposed, with a new Turkish emotional music database constructed for evaluation. The method shows significant improvement in accuracy using feature combination and LSTM + DNN classifier, indicating its potential in music emotion recognition.
ENGINEERING SCIENCE AND TECHNOLOGY-AN INTERNATIONAL JOURNAL-JESTECH
(2021)
Article
Neurosciences
Erin L. Grafe, Christine J. Fontaine, Jennifer D. Thomas, Brian R. Christie
Summary: Choline directly impacts synaptic communication in the brain, inducing a long-term depression of synaptic efficacy in both male and female animals. It involves M1 receptors in control animals, but uniquely involves NMDA receptors in a model of FASD.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Physiology
Pietro Maria Bertelli, Edoardo Pedrini, David Hughes, Shannon McDonnell, Varun Pathak, Elisa Peixoto, Jasenka Guduric-Fuchs, Alan W. Stitt, Reinhold J. Medina
Summary: Long-term exposure to 25 mM D-glucose accelerated the establishment of cellular senescence in human retinal microvascular endothelial cells, leading to decreased clonogenic capacity, diminished tubulogenicity, and impaired barrier function.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Neurosciences
Taylor Boggess, W. Christopher Risher
Summary: Coinciding with the opioid epidemic, there has been a significant increase in the number of neonatal abstinence syndrome (NAS) cases in the United States. Current research on NAS has mainly focused on short-term care, neglecting long-term effects of prenatal opioid exposure (POE) on brain development. This review summarizes the current state of NAS research, highlighting how POE can lead to prolonged deficits in brain structure and function. Future research needs to focus on alleviating this growing multigenerational threat posed by NAS.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Behavioral Sciences
Eino Partanen, Riia Kivimaki, Minna Huotilainen, Sari Ylinen, Mari Tervaniemi
Summary: This study suggests that musical activities can support language skills in children with developmental language difficulties and that perceptual musical skills are directly linked with reading proficiency. However, auditory processing in the brain does not seem to strongly correlate with reading proficiency in typically developing children.
Article
Behavioral Sciences
Valtteri Wikstrom, Katri Saarikivi, Mari Falcon, Tommi Makkonen, Silja Martikainen, Vesa Putkinen, Benjamin Ultan Cowley, Mari Tervaniemi
Summary: Inter-brain synchronization during social interaction is associated with positive phenomena such as closeness, cooperation, prosociality, and team performance. This study investigates the temporal dynamics of inter-brain synchronization during online collaboration and demonstrates that phase synchronization of oscillatory activity occurs without physical co-presence or audio-visual connection. The results further show that inter-brain synchrony is associated with momentary and mean performance during joint coordination.
Article
Pediatrics
Kaisamari Kostilainen, Pernilla Hugoson, Anu Haavisto, Eino Partanen, Kaija Mikkola, Minna Huotilainen, Satu Pakarinen, Catarina Furmark, Ulrika Aden, Vineta Fellman
Summary: This study aims to examine the long-term effects of neonatal music interventions on the cognition of preterm-born children. The results showed that a singing intervention by parents did not improve cognitive and language skills, and there were no associations between the amount of singing and cognitive and language scores.
Article
Neurosciences
P. Virtala, T. Kujala, E. Partanen, J. A. Hamalainen, I. Winkler
Summary: This study explores the importance of phonetic learning readiness in newborns for their emerging language skills. It suggests that problems in learning phonemes may contribute to the phonological deficits observed in dyslexia. The study also found that infants with severe dyslexia in their parents had diminished mismatch responses, indicating difficulties in grouping complex sounds into distinct auditory categories.
BRAIN AND COGNITION
(2023)
Article
Neurosciences
K. Saarikivi, T. M. Chan, M. Huotilainen, M. Tervaniemi, V Putkinen
Summary: Musically trained individuals show better performance in executive functions tasks, particularly in set shifting, but this advantage diminishes as they grow older. However, trained adolescents still exhibit more efficient brain activation and distinct scalp topography in set-shifting tasks.
Review
Neurosciences
Mari Tervaniemi
Summary: Over the past two decades, studies in the neuroscience of music have shifted from well-controlled experimental research to more naturalistic and ecologically valid paradigms. This article introduces this shift in terms of sound stimulation, empirical paradigms, study participants, and methods of data acquisition. The aim is to provide a historical overview of the field's development and stimulate innovative thinking to enhance the ecological validity of studies while maintaining experimental rigor.
TRENDS IN NEUROSCIENCES
(2023)
Review
Neurosciences
Teija Kujala, Eino Partanen, Paula Virtala, Istvan Winkler
Summary: Learning to decode and produce speech is a challenging task for infants, but they are able to utter their first words within a year and learn phrases quickly. Studies on neural activity suggest that newborns have core auditory abilities, such as statistical learning and rule extraction from speech input, which enable them to acquire language efficiently. The neonatal brain is prepared to categorize sounds, detect word boundaries, and learn and separate speech streams from everyday linguistic input.
TRENDS IN NEUROSCIENCES
(2023)
Article
Psychology, Multidisciplinary
Ita Puusepp, Tanja Linnavalli, Tuisku Tammi, Minna Huotilainen, Teija Kujala, Sonja Laine, Elina Kuusisto, Kirsi Tirri
Summary: The aim of this study was to examine the development of associations between elementary school students' mindsets and attentional neural processing of positive and negative feedback in math. Data from 100 Finnish elementary school students were analyzed and it was found that students' fixed mindsets about general intelligence and math ability were associated with greater attention allocated to positive feedback. Additionally, a marginal association was found between students' fixed general intelligence mindset and attention allocated to negative feedback, mainly in grade 4.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Developmental
Virtala Paula, Putkinen Vesa, Gallen Anastasia, Thiede Anja, J. Trainor Laurel, Kujala Teija
Summary: Family history of dyslexia can affect auditory and speech processing, language, and literacy development. This study explored the benefits of music interventions for infants at risk for language and reading disorders. The results suggest that vocal music listening in early infancy can enhance phonological development and support speech processing.
DEVELOPMENTAL SCIENCE
(2023)
Article
Education & Educational Research
Silja Martikainen, Mirjam Kalland, Tanja Linnavalli, Kaisamari Kostilainen, Metsaemarja Aittokoski, Jyrki Reunamo, Zoi Vasileiou, Mari Tervaniemi
Summary: A randomized controlled trial was conducted to investigate the effectiveness of two 10-week early childhood education and care interventions, SAGA and Pikkuli, in supporting social-emotional and verbal development. The results showed that children in both intervention groups exhibited improvements in prosocial behavior and had fewer internalizing problems after the intervention. These findings suggest that both interventions have the potential to support children's social-emotional development in the early childhood education and care environment.
SCANDINAVIAN JOURNAL OF EDUCATIONAL RESEARCH
(2023)
Article
Linguistics
Cuicui Wang, Krystal Flemming, Yanpei Wang, Vesa Putkinen, Mari Tervaniemi, Jessica Lammert, Sha Tao, Marc F. Joanisse
Summary: This study aimed to investigate the effects of second language immersion and musical experience on second language speech and general auditory processing. The results showed that immersed English learners and native English speakers exhibited larger mismatch negativity (MMN) in the speech oddball task compared to intermediate English learners and native Chinese-speaking musicians, suggesting that second language immersion experience can facilitate speech processing. However, there were no significant differences in MMN for general auditory processing among the groups. The findings suggest that the effect of second language immersion is domain-specific and can specifically enhance speech perception. This study contributes to a better understanding of the role of different learning experiences in second language acquisition.
JOURNAL OF NEUROLINGUISTICS
(2023)
