Rhein, a Natural Anthraquinone Derivative, Attenuates the Activation of Pancreatic Stellate Cells and Ameliorates Pancreatic Fibrosis in Mice with Experimental Chronic Pancreatitis

The Hedgehog System Machinery Controls Transforming Growth Factor-β–Dependent Myofibroblastic Differentiation in Humans

(2012) Natacha Cigna et al.   AMERICAN JOURNAL OF PATHOLOGY

Hedgehog-Gli Pathway Activation during Kidney Fibrosis

(2012) Steven L. Fabian et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis

(2012) Angelika Horn et al.   ANNALS OF THE RHEUMATIC DISEASES

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

(2012) Angelika Horn et al.   ARTHRITIS AND RHEUMATISM

The Impact of the Activated Stroma on Pancreatic Ductal Adenocarcinoma Biology and Therapy Resistance

(2012) Mert Erkan et al.   CURRENT MOLECULAR MEDICINE

Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans

(2012) James Pritchett et al.   HEPATOLOGY

Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma

(2012) Dong Tang et al.   INTERNATIONAL JOURNAL OF CANCER

Reduced system exposures of total rhein and baicalin after combinatory oral administration of rhein, baicalin and berberine to beagle dogs and rats

(2012) Zhanguo Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis

(2012) H. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice

(2011) Xiaoyan Sheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Emodin Inhibits Proinflammatory Responses and Inactivates Histone Deacetylase 1 in Hypoxic Rheumatoid Synoviocytes

(2011) Mi-Kyoung Ha et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Preventive Effects and Mechanisms of Rhein on Renal Interstitial Fibrosis in Obstructive Nephropathy

(2011) Dongyuan He et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro

(2011) Vivian E. Fernand et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Novel Rhein Analogues as Potential Anticancer Agents

(2011) Xiaochuan Yang et al.   ChemMedChem

Chronic pancreatitis

(2011) Matthew J. DiMagno et al.   CURRENT OPINION IN GASTROENTEROLOGY

StellaTUM: current consensus and discussion on pancreatic stellate cell research

(2011) Mert Erkan et al.   GUT

ER Stress, P66shc, and P-Akt/Akt Mediate Adjuvant-Induced Inflammation, Which Is Blunted by Argirein, a Supermolecule and Rhein in Rats

(2011) Xiao-Dong Cong et al.   INFLAMMATION

Rhein: A potential biological therapeutic drug for intervertebral disc degeneration

(2011) Hao Li et al.   MEDICAL HYPOTHESES

MT1-MMP Cooperates with KrasG12D to Promote Pancreatic Fibrosis through Increased TGF-  Signaling

(2011) S. B. Krantz et al.   MOLECULAR CANCER RESEARCH

Analysis of the Human Pancreatic Stellate Cell Secreted Proteome

(2011) Angela Y. Wehr et al.   PANCREAS

Oxidative damage and TGF-β differentially induce lung epithelial cell sonic hedgehog and tenascin-C expression: implications for the regulation of lung remodelling in idiopathic interstitial lung disease

(2010) Paul M. Fitch et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

GLI2-Mediated Melanoma Invasion and Metastasis

(2010) Vasileia-Ismini Alexaki et al.   JNCI-Journal of the National Cancer Institute

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

Anti-angiogenic effect and mechanism of rhein from Rhizoma Rhei

(2010) Zhi-Heng He et al.   PHYTOMEDICINE

Potent Anti-Inflammatory Effects of Denbinobin Mediated by Dual Inhibition of Expression of Inducible No Synthase and Cyclooxygenase 2

(2010) Hsiang-Erh Liu et al.   SHOCK

Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh

(2009) Akio Yamasaki et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Sonic Hedgehog Pathway Activation Is Induced by Acute Brain Injury and Regulated by Injury-Related Inflammation

(2009) N. M. Amankulor et al.   JOURNAL OF NEUROSCIENCE

In vitro anti-fibrotic activities of herbal compounds and herbs

(2009) Qin Hu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Microcalorimetric assay on the antimicrobial property of five hydroxyanthraquinone derivatives in rhubarb (Rheum palmatum L.) to Bifidobacterium adolescentis

(2009) J. Wang et al.   PHYTOMEDICINE

Liver fibrosis

(2008) Karen Wallace et al.   BIOCHEMICAL JOURNAL

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

Characterization of sonic hedgehog as a novel NF-κB target gene that promotes NF-κB-mediated apoptosis resistance and tumor growth in vivo

(2008) Hubert Kasperczyk et al.   FASEB JOURNAL