An Anthelmintic Drug, Pyrvinium Pamoate, Thwarts Fibrosis and Ameliorates Myocardial Contractile Dysfunction in a Mouse Model of Myocardial Infarction

Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis

(2013) Li Ma et al.   CELL

Cancer metabolism in breadth and depth

(2013) Matthew G H Chun et al.   NATURE BIOTECHNOLOGY

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

(2013) Jie Hu et al.   NATURE BIOTECHNOLOGY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

An anticancer agent, pyrvinium pamoate inhibits the NADH–fumarate reductase system—a unique mitochondrial energy metabolism in tumour microenvironments

(2012) Eriko Tomitsuka et al.   JOURNAL OF BIOCHEMISTRY

Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration

(2012) Isao Ishii et al.   Frontiers in Oncology

Mitochondrial fumarate reductase as a target of chemotherapy: From parasites to cancer cells

(2011) Chika Sakai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3

(2011) Yasuo Harada et al.   CANCER LETTERS

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

(2010) Curtis A Thorne et al.   Nature Chemical Biology

Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Promotes Wound Repair and Post-MI Cardiac Remodeling

(2010) Sarika Saraswati et al.   PLoS One

Non-competitive androgen receptor inhibition in vitro and in vivo

(2009) J. O. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cellular Conformation-Based Screen for Androgen Receptor Inhibitors

(2008) Jeremy O. Jones et al.   ACS Chemical Biology

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

(2008) Koichi Kobayashi et al.   NATURE CELL BIOLOGY

Pyrvinium Targets the Unfolded Protein Response to Hypoglycemia and Its Anti-Tumor Activity Is Enhanced by Combination Therapy

(2008) De-Hua Yu et al.   PLoS One