Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain
Authors
Keywords
-
Journal
PLoS One
Volume 8, Issue 12, Pages e84147
Publisher
Public Library of Science (PLoS)
Online
2013-12-20
DOI
10.1371/journal.pone.0084147
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height
- (2015) Katrina Tatton-Brown et al. Oncotarget
- Exome sequencing identifies putative drivers of progression of transient myeloproliferative disorder to AMKL in infants with Down syndrome
- (2013) S. I. Nikolaev et al. BLOOD
- Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells
- (2013) Eunhee Kim et al. CANCER CELL
- EZH2 Mutations Are Related to Low Blast Percentage in Bone Marrow and -7/del(7q) in De Novo Acute Myeloid Leukemia
- (2013) Xiuli Wang et al. PLoS One
- A somatic EZH2 mutation in childhood acute myeloid leukemia
- (2012) T Ernst et al. LEUKEMIA
- TET2, ASXL1 and EZH2 mutations in Chinese with myelodysplastic syndromes
- (2012) Jieyu Wang et al. LEUKEMIA RESEARCH
- EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex
- (2012) Ji Min Lee et al. MOLECULAR CELL
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
- (2012) Jinghui Zhang et al. NATURE
- Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
- (2012) M. T. McCabe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
- (2012) W. Qi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
- (2012) J. G. Lohr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
- (2012) K. Xu et al. SCIENCE
- REFMAC5 for the refinement of macromolecular crystal structures
- (2011) Garib N. Murshudov et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Overview of theCCP4 suite and current developments
- (2011) Martyn D. Winn et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Mutations in EZH2 Cause Weaver Syndrome
- (2011) William T. Gibson et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
- (2011) A. M. Jankowska et al. BLOOD
- EZH2 mutational status predicts poor survival in myelofibrosis
- (2011) P. Guglielmelli et al. BLOOD
- The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation
- (2011) Qi Qiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal Structure of the Human Histone Methyltransferase ASH1L Catalytic Domain and Its Implications for the Regulatory Mechanism
- (2011) Sojin An et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- EZH2 Y641 mutations in follicular lymphoma
- (2011) C Bödör et al. LEUKEMIA
- Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance
- (2011) V Grossmann et al. LEUKEMIA
- Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
- (2011) Ryan D. Morin et al. NATURE
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
- (2010) D. B. Yap et al. BLOOD
- EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-β1 and is a predictor of outcome in ovarian carcinoma patients
- (2010) Zhi-Yue Rao et al. CARCINOGENESIS
- SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation
- (2010) Paul A. Del Rizzo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
- (2010) H Makishima et al. LEUKEMIA
- Enhancer of Zeste Homolog 2 Promotes the Proliferation and Invasion of Epithelial Ovarian Cancer Cells
- (2010) H. Li et al. MOLECULAR CANCER RESEARCH
- Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
- (2010) Gorica Nikoloski et al. NATURE GENETICS
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
- (2010) Thomas Ernst et al. NATURE GENETICS
- Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells
- (2010) F. Orzan et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Structural Biology of Human H3K9 Methyltransferases
- (2010) Hong Wu et al. PLoS One
- EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance
- (2009) M.-L. Suva et al. CANCER RESEARCH
- High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy
- (2009) Li-Ru He et al. INTERNATIONAL JOURNAL OF CANCER
- Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers
- (2008) Yongkun Wei et al. MOLECULAR CARCINOGENESIS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started