A Novel Pulse-Chase SILAC Strategy Measures Changes in Protein Decay and Synthesis Rates Induced by Perturbation of Proteostasis with an Hsp90 Inhibitor

Introduction to Theme “Chromatin, Epigenetics, and Transcription”

(2012) Joan W. Conaway   Annual Review of Biochemistry

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Protein Turnover Quantification in a Multilabeling Approach: From Data Calculation to Evaluation

(2012) Christian Trötschel et al.   MOLECULAR & CELLULAR PROTEOMICS

Systematic Identification of the HSP90 Regulated Proteome

(2012) Zhixiang Wu et al.   MOLECULAR & CELLULAR PROTEOMICS

Deciphering a global network of functionally associated post-translational modifications

(2012) Pablo Minguez et al.   Molecular Systems Biology

The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

(2012) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Proteome Scale Turnover Analysis in Live Animals Using Stable Isotope Metabolic Labeling

(2011) Yaoyang Zhang et al.   ANALYTICAL CHEMISTRY

Quality control and fate determination of Hsp90 client proteins

(2011) Maria A. Theodoraki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting

(2011) Aaron Ciechanover   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Data Processing Pipeline for Mammalian Proteome Dynamics Studies Using Stable Isotope Metabolic Labeling

(2011) Shenheng Guan et al.   MOLECULAR & CELLULAR PROTEOMICS

Systematic Analysis of Protein Pools, Isoforms, and Modifications Affecting Turnover and Subcellular Localization

(2011) Yasmeen Ahmad et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response

(2011) Kirti Sharma et al.   MOLECULAR & CELLULAR PROTEOMICS

A Quantitative Spatial Proteomics Analysis of Proteome Turnover in Human Cells

(2011) François-Michel Boisvert et al.   MOLECULAR & CELLULAR PROTEOMICS

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Determinants of translation efficiency and accuracy

(2011) H. Gingold et al.   Molecular Systems Biology

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells

(2011) Michal Rabani et al.   NATURE BIOTECHNOLOGY

Proteome Half-Life Dynamics in Living Human Cells

(2011) E. Eden et al.   SCIENCE

Meta-analysis of heat- and chemically upregulated chaperone genes in plant and human cells

(2010) Andrija Finka et al.   CELL STRESS & CHAPERONES

Multitagging Proteomic Strategy to Estimate Protein Turnover Rates in Dynamic Systems

(2010) Karthik P. Jayapal et al.   JOURNAL OF PROTEOME RESEARCH

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Analysis of proteome dynamics in the mouse brain

(2010) J. C. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation of mRNA and protein in complex biological samples

(2009) Tobias Maier et al.   FEBS LETTERS

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

(2009) E. Caldas-Lopes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Dynamics in Iron-StarvedMycobacterium tuberculosisRevealed by Turnover and Abundance Measurement Using Hybrid-Linear Ion Trap-Fourier Transform Mass Spectrometry

(2008) Prahlad K. Rao et al.   ANALYTICAL CHEMISTRY

SILAC Mouse for Quantitative Proteomics Uncovers Kindlin-3 as an Essential Factor for Red Blood Cell Function

(2008) Marcus Krüger et al.   CELL

Genes and genetic networks responsive to mild hyperthermia in human lymphoma U937 cells

(2008) Yoshiaki Tabuchi et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Turnover of the Human Proteome: Determination of Protein Intracellular Stability by Dynamic SILAC

(2008) Mary K. Doherty et al.   JOURNAL OF PROTEOME RESEARCH

QuantiSpec — Quantitative mass spectrometry data analysis of 15N-metabolically labeled proteins

(2008) Katrin Haegler et al.   Journal of Proteomics

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors

(2008) J R Smith et al.   ONCOGENE

Global analysis of cellular protein translation by pulsed SILAC

(2008) Björn Schwanhäusser et al.   PROTEOMICS

Global Protein Stability Profiling in Mammalian Cells

(2008) H.-C. S. Yen et al.   SCIENCE