Topoisomerase I Inhibitors, Shikonin and Topotecan, Inhibit Growth and Induce Apoptosis of Glioma Cells and Glioma Stem Cells

Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target

(2015) Fang Zhang et al.   Oncotarget

A review of the role of stem cells in the development and treatment of glioma

(2012) Richard M. Heywood et al.   ACTA NEUROCHIRURGICA

Novel Multiple Apoptotic Mechanism of Shikonin in Human Glioma Cells

(2012) Ching-Hsein Chen et al.   ANNALS OF SURGICAL ONCOLOGY

uPAR and cathepsin B inhibition enhanced radiation-induced apoptosis in gliomainitiating cells

(2012) R. R. Malla et al.   NEURO-ONCOLOGY

Quantitative analysis of topoisomerase II alpha and evaluation of its effects on cell proliferation and apoptosis in glioblastoma cancer stem cells

(2012) Yang Hong et al.   NEUROSCIENCE LETTERS

Glioblastoma stem cells

(2011) Ghazaleh Tabatabai et al.   CELL AND TISSUE RESEARCH

Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells

(2010) I-Chang Chang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells

(2010) Nie Yingkun et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Differential impact of high-dose cyclophosphamide, topotecan, and vincristine in clinical subsets of patients with chemoresistant neuroblastoma

(2010) Brian H. Kushner et al.   CANCER

Immunohistochemical Expression of Stem Cell, Endothelial Cell, and Chemosensitivity Markers in Primary Glioma Spheroids Cultured in Serum-Containing and Serum-Free Medium

(2010) Karina Christensen et al.   NEUROSURGERY

Shikonin inhibits tumor invasion via down-regulation of NF-κB-mediated MMP-9 expression in human ACC-M cells

(2010) R Min et al.   ORAL DISEASES

Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas

(2010) Ramarao Malla et al.   PLoS One

Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis

(2009) Weidong Han et al.   APOPTOSIS

Isolation and characterization of cancer stem like cells in human glioblastoma cell lines

(2009) Lei Qiang et al.   CANCER LETTERS

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

(2009) Yves Pommier   CHEMICAL REVIEWS

Topotecan Triggers Apoptosis in p53-Deficient Cells by Forcing Degradation of XIAP and Survivin Thereby Activating Caspase-3-Mediated Bid Cleavage

(2009) M. T. Tomicic et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis

(2009) F. Bruzzese et al.   MOLECULAR CANCER THERAPEUTICS

Topoisomerase I and IIα protein expression in primary colorectal cancer and recurrences following 5-fluorouracil-based adjuvant chemotherapy

(2008) Nicolas Tsavaris et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells

(2008) Xin Mao et al.   CELL RESEARCH

Shikonin exerts antitumor activityviaproteasome inhibition and cell death inductionin vitroandin vivo

(2008) Huanjie Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Side populations of gastrointestinal cancers are not enriched in stem cells

(2008) J Burkert et al.   JOURNAL OF PATHOLOGY