Article
Oncology
Alexander Piening, Anand Swaminath, John Dombrowski, Ryan M. Teague, Noor Al-Hammadi, Jeevin Shahi
Summary: The study found that advanced hepatocellular carcinoma patients who received ST+SBRT had better overall survival compared to those who received ST alone. This suggests that combination therapy plays a positive role in improving survival in patients with advanced HCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Thomas B. Brunner, Dominik Bettinger, Michael Schultheiss, Lars Maruschke, Lukas Sturm, Nico Bartl, Ivana Koundurdjieva, Simon Kirste, Hannes P. Neeff, Christian Goetz, Nils Henrik Nicolay, Gabriele Ihorst, Fabian Bamberg, Robert Thimme, Anca-Ligia Grosu, Eleni Gkika
Summary: The study findings indicate that SBRT is an effective and well-tolerated local treatment for patients with hepatocellular carcinoma, providing high rates of local control and maintaining quality of life for patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Pablo Munoz-Schuffenegger, Aisling Barry, Eshetu G. Atenafu, John Kim, James Brierley, Jolie Ringash, Anthony Brade, Robert Dinniwell, Rebecca K. S. Wong, Charles Cho, Tae Kyoung Kim, Gonzalo Sapisochin, Laura A. Dawson
Summary: This study investigated the long-term outcomes of patients with HCC and MVI treated with SBRT, showing promising results in terms of local control and overall survival. Patients who received sorafenib treatment after SBRT had longer survival, but some patients experienced adverse events like gastrointestinal bleeding.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Changchen Jiang, Shenghua Jing, Han Zhou, Aomei Li, Xiangnan Qiu, Xixu Zhu, Zetian Shen
Summary: The combination of TACE and CyberKnife SBRT demonstrated optimal efficacy and tolerable toxicity in treating BCLC stage B HCC. Results indicated high rates of local control and survival among patients in the study.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Isaure Roquette, Emilie Bogart, Thomas Lacornerie, Massih Ningarhari, Jean-Emmanuel Bibault, Marie-Cecile Le Deley, Eric F. Lartigau, David Pasquier, Xavier Mirabel
Summary: This study describes the treatment efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with hepatocellular carcinoma (HCC). The analysis of data from 318 patients showed that SBRT is efficient for the management of HCC with a favorable toxicity profile.
Article
Gastroenterology & Hepatology
Yuri Jeong, Kyung Jin Lee, So Jung Lee, Yong Moon Shin, Min-Ju Kim, Young-Suk Lim, Han Chu Lee, Jinhong Jung, Jin-hong Park, Jong Hoon Kim, So Yeon Kim, Sang Min Yoon
Summary: This study compared the clinical outcomes of radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma patients, finding comparable results in terms of local control rates, overall survival rates, and intrahepatic recurrence-free survival rates. SBRT appears to be a viable alternative method for small hepatocellular carcinomas that are not suitable for RFA due to tumor location.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Zi-liang Yang, Xu-qi Sun, Yu-hao Tang, Pei-yao Xiong, Li Xu
Summary: Liver resection (LR) remains the best choice for AJCC stage I hepatocellular carcinoma (HCC) patients, regardless of tumor size. For HCC ≤ 2 cm, stereotactic body radiation therapy (SBRT) can be an alternative treatment to radiofrequency ablation (RFA). For HCC > 2 cm, RFA provides better long-term survival than SBRT.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ting-Shi Su, Qiu-Hua Liu, Xiao-Fei Zhu, Ping Liang, Shi-Xiong Liang, Lin Lai, Ying Zhou, Yong Huang, Tao Cheng, Le-Qun Li
Summary: This study found that higher radiotherapy doses are associated with better outcomes for HCC patients, with SaRT and SbRT showing better improvement in OS, PFS, and intrahepatic control compared to ScRT.
RADIATION ONCOLOGY
(2021)
Article
Medicine, General & Internal
Bakhtawar Memon, Shazia Kadri, Nimrah Sultana, Kamran Saeed, Naveed Ahmed, Tariq Mahmood
Summary: The study aimed to assess the effectiveness of SBRT in HCC patients and found significant associations between survival rates at different time points and factors such as ECOG performance status, AFP levels, age, HBV infection, and previous treatment. No complications or radiation-induced liver toxicity were reported among the patients.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Article
Oncology
Marie Cantaloube, Florence Castan, Morgane Creoff, Jessica Prunaretty, Karl Bordeau, Morgan Michalet, Eric Assenat, Boris Guiu, Georges-Philippe Pageaux, Marc Ychou, Norbert Ailleres, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: The study demonstrates that stereotactic body radiation therapy (SBRT) using volumetric modulated arc therapy (VMAT) and real-time adaptive tumor gating for hepatocellular carcinoma (HCC) is effective with optimal local control and low toxicity, especially in patients not eligible for other local therapies. Additionally, the diameter of lesions and the volume of PTV were found to be associated with disease-free survival and overall survival in HCC patients receiving SBRT with VMAT.
Article
Medicine, General & Internal
Ye Liu, Xiaohong Liu, Yang Gu, Haofeng Lu
Summary: This study investigated RNA-binding proteins (RBPs) in HCC patients using RNA-seq and microarray datasets to construct a prognostic model that can reliably predict HCC patients' overall survival. The model accurately predicted the prognosis of liver cancer patients and helped identify high-risk patients, thus optimizing individualized treatment decision-making. The risk scores obtained by the model were highly correlated with immune cell infiltration, showing the potential for a more personalized approach to HCC treatment.
Article
Oncology
Yue Zhong, Yong Yang, Lei He, Yang Zhou, Niangmei Cheng, Geng Chen, Bixing Zhao, Yingchao Wang, Gaoxiong Wang, Xiaolong Liu
Summary: This study developed a novel prognostic evaluation model based on the expression of lncRNAs to predict the survival and early recurrence of HCC patients, successfully dividing them into low-risk and high-risk groups with significantly different outcomes. The model showed high performance in predicting OS and 2-year RFS in both training and validation cohorts, with potential implications in immune escape and treatment resistance in high-risk HCC tumor tissues.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Oncology
Lidi Ma, Kan Deng, Cheng Zhang, Haixia Li, Yingwei Luo, Yingsi Yang, Congrui Li, Xinming Li, Zhijun Geng, Chuanmiao Xie
Summary: This study aimed to develop nomograms for predicting 5-year overall survival and early recurrence after curative resection of hepatocellular carcinoma (HCC), and investigate the impact of different treatment methods on patient outcomes. The results showed that the nomograms demonstrated good accuracy in predicting survival and recurrence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Yang Zhang, Yi Zhang, Taiyu He, Guangliang Liu, Minjie Duan, Jian Huang, Christy Huang, Scott Lowe, Dazhi Ke, Xiaozhu Liu, Junyi Cao
Summary: Liver resection (LR) and local tumor destruction (LTD) improve overall survival (OS) in patients with intermediate/advanced hepatocellular carcinoma (HCC). A nomogram model was developed to predict OS and select suitable patients for LR/LTD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiao-fei Zhang, Lin Lai, Hui Zhou, Yuan-jun Mo, Xu-quan Lu, Min Liu, Yun-xin Lu, En-cun Hou
Summary: This meta-analysis suggests that SBRT plus TACE is superior to monotherapy in treating HCC with PVTT, as it improves survival rates and treatment response without significant increase in adverse events.
Article
Medicine, General & Internal
Lipika Goyal, Funda Meric-Bernstam, Antoine Hollebecque, Juan W. Valle, Chigusa Morizane, Thomas B. Karasic, Thomas A. Abrams, Junji Furuse, Robin K. Kelley, Philippe A. Cassier, Heinz-Josef Kluempen, Heung-Moon Chang, Li-Tzong Chen, Josep Tabernero, Do-Youn Oh, Amit Mahipal, Markus Moehler, Edith P. Mitchell, Yoshito Komatsu, Kunihiro Masuda, Daniel Ahn, Robert S. Epstein, Abdel-Baset Halim, Yao Fu, Tehseen Salimi, Volker Wacheck, Yaohua He, Mei Liu, Karim A. Benhadji, John A. Bridgewater
Summary: In this study, 103 patients with FGFR2-altered intrahepatic cholangiocarcinoma were treated with futibatinib for a median duration of 17.1 months. The results showed that futibatinib treatment could effectively inhibit tumor growth, improve survival, and maintain quality of life for patients.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Frederik Crop, Clemence Robert, Romain Viard, Julien Dumont, Marine Kawalko, Pauline Makala, Xavier Liem, Imen El Aoud, Aicha Ben Miled, Victor Chaton, Lucas Patin, David Pasquier, Ophelie Guillaud, Benjamin Vandendorpe, Xavier Mirabel, Luc Ceugnart, Camille Decoene, Thomas Lacornerie
Summary: The study aimed to compare different DWI techniques in terms of SNR efficiency, ADC accuracy, artifacts, and distortions. Through evaluation on a phantom and 51 patients, it was found that ZoomitPro and TSE SPLICE techniques showed a trade-off between efficiency and artifacts, and the quality control of phantom ADC largely underestimated the in vivo accuracy.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Nolwenn Delaby, Anais Barateau, Sophie Chiavassa, Marie-Claude Biston, Philippe Chartier, Eliane Graulieres, Lucie Guinement, Sandrine Huger, Thomas Lacornerie, Corinne Millardet-Martin, Alain Sottiaux, Jerome Caron, David Gensanne, Yoann Pointreau, Alexandre Coutte, Julian Biau, Anne-Agathe Serre, Joel Castelli, Milan Tomsej, Robin Garcia, Catherine Khamphan, Aurelien Badey
Summary: This paper provides an overview of the key steps and tools of a head and neck adaptive radiotherapy (ART) workflow from the perspective of French-speaking medical physicists and physicians from GORTEC. The focus is on image registration, segmentation, estimation of delivered dose of the day, workflow, and quality assurance for implementing H&N offline and online ART. Practical recommendations are given to assist physicians and medical physicists in a clinical workflow.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Frederik Crop, Julien Laffarguette, Ilias Achag, David Pasquier, Xavier Mirabel, Romain Cayez, Thomas Lacornerie
Summary: The study aims to evaluate the accuracy and agreement of a three-camera Catalyst Surface Guided radiation therapy system on a closed-gantry Halcyon for breast-only treatments under free-breathing and deep inspiration breath hold conditions. The agreement of SGRT positioning with the Halcyon couch and cone-beam computed tomography (CBCT) was evaluated and compared with the CBCT positioning. The results showed good agreement between SGRT and Halcyon couch, while some systematic differences were observed between SGRT and CBCT positioning.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2023)
Article
Oncology
Yoann Pradat, Julien Viot, Andrey A. Yurchenko, Konstantin Gunbin, Luigi Cerbone, Marc Deloger, Guillaume Grisay, Loic Verlingue, Veronique Scott, Ismael Padioleau, Leonardo Panunzi, Stefan Michiels, Antoine Hollebecque, Gerome Jules-Clement, Laura Mezquita, Antoine Laine, Yohann Loriot, Benjamin Besse, Luc Friboulet, Fabrice Andre, Paul-Henry Cournede, Daniel Gautheret, Sergey I. Nikolaev
Summary: Metastatic relapse after treatment is the main cause of cancer mortality, with unknown resistance mechanisms for most treatments. To address this issue, a pan-cancer cohort (META-PRISM) of 1,031 refractory metastatic tumors was analyzed. META-PRISM tumors, especially prostate, bladder, and pancreatic types, exhibited the most transformed genomes compared to untreated tumors. Standard-of-care resistance biomarkers were identified in only 9.6% of META-PRISM tumors, indicating a lack of clinical validation for resistance mechanisms. However, investigational and hypothetical resistance mechanisms were enriched in treated patients, supporting their potential role in treatment resistance. Furthermore, molecular markers improved 6-month survival prediction, particularly for advanced breast cancer patients. The META-PRISM cohort proves valuable for studying resistance mechanisms and conducting predictive analysis in cancer.
Article
Multidisciplinary Sciences
Karen Leroy, Clarisse Audigier Valette, Jerome Alexandre, Lise Boussemart, Jean Chiesa, Clotilde Deldycke, Carlos Gomez-Rocca, Antoine Hollebecque, Jacqueline Lehmann-Che, Antoinette Lemoine, Sandrine Mansard, Jacques Medioni, Isabelle Monnet, Samia Mourah, Thomas Pierret, Dominique Spaeth, Alexandre Civet, Sandrine Galoin, Antoine Italiano, Tomoki Yamano
Summary: This French study provides information on the real-life actionability of a CGP test based on tissue samples, and trends to confirm its utility in clinical practice across the course of the disease, particularly for patients with lung cancer and/or advanced disease.
Article
Oncology
Francesco Facchinetti, Antoine Hollebecque, Floriane Braye, Damien Vasseur, Yoann Pradat, Rastislav Bahleda, Cedric Pobel, Ludovic Bigot, Olivier Deas, Juan DavidFlorez Arango, Giorgia Guaitoli, Hayato Mizuta, David Combarel, Lambros Tselikas, Stefan Michiels, Sergey I. Nikolaev, Jean-Yves Scoazec, Santiago Ponce-Aix, Benjamin Besse, Ken A. Olaussen, Yohann Loriot, Luc Friboulet
Summary: In this study, we identified a high frequency of FGFR kinase domain mutations responsible for resistance to FGFR inhibitors in urothelial cancer patients. Off-target resistance mechanisms mainly involved the PI3K-mTOR pathway. Our findings provide preclinical evidence supporting combinatorial treatment strategies to overcome bypass resistance.
Review
Oncology
Marine Valery, Damien Vasseur, Francesco Fachinetti, Alice Boileve, Cristina Smolenschi, Anthony Tarabay, Leony Antoun, Audrey Perret, Alina Fuerea, Thomas Pudlarz, Valerie Boige, Antoine Hollebecque, Michel Ducreux
Summary: Biliary tract cancers are rare and often diagnosed at an advanced stage with poor prognosis. Only limited first- and second-line treatments are available, and there is a high rate of targetable somatic alterations. FDA has approved several drugs, but there are still other potentially targetable alterations that require further research.
Meeting Abstract
Oncology
Yoann Pradat, Julien Viot, Konstantin Gunbin, Andrey Yurchenko, Luigi Cerbone, Marc Deloger, Guillaume Grisay, Loic Verlingue, Veronique Scott, Ismael Padioleau, Leonardo Panunzi, Stefan Michiels, Antoine Hollebecque, Gerome Jules-Clement, Laura Mezquita, Antoine Laine, Yohann Loriot, Benjamin Besse, Luc Friboulet, Fabrice Andre, Paul-Henry Cournede, Daniel Gautheret, Sergey Nikolaev
Meeting Abstract
Oncology
Francesco Facchinetti, Antoine Hollebecque, Floriane Braye, Damien Vasseur, Yoann Pradat, Rastislav Bahleda, Cedric Pobel, Ludovic Bigot, Olivier Deas, Juan-David Florez-Arango, Giorgia Guaitoli, Hayato Mizuta, David Combarel, Lambros Tselikas, Stefan Michiels, Sergey Nikolaev, Jean-Yves Scoazec, Santiago Ponce-Aix, Benjamin Besse, Ken A. Olaussen, Yohann Loriot, Luc Friboulet
Meeting Abstract
Oncology
Marc Diez Garcia, Antoine Hollebecque, Rocio Garcia-Carbonero, Christiane Jungels, Elisabeth Smyth, Shumei Kato, Guillem Argiles, Carlos Gomez Martin, Marina Magin, Yu-Ming Shen, Renee de Leeuw, Mohamed Bekradda, Eduardo Pennella, Ernesto Wasserman, Viktoriya Stalbovskaya, Jeroen Lammerts van Bueren, Aline Engbers, Andrew Joe, Josep Tabernero
Meeting Abstract
Oncology
Yonina R. Murciano-Goroff, Rebecca S. Heist, Yasutoshi Kuboki, Takafumi Koyama, Natraj Reddy Ammakkanavar, Antoine Hollebecque, Amita Patnaik, Toshio Shimizu, Alexander I. Spira, Misako Nagasaka, Ji-Youn Han, Wade Thomas Iams, Dustin Deming, Justin Call, Philippe Cassier, Sae-Won Han, Quincy Siu-Chung Chu, Rasha Cosman, Gregory Durm, Timothy Burns, Melinda D. Willard, Shiyao Liu, Sophie Callies, Arjun V. Balar, Joshua K. Sabari
Meeting Abstract
Oncology
Jordi Rodon, Lipika Goyal, Teresa Macarulla Mercade, Masafumi Ikeda, Shunsuke Kondo, Do-Youn Oh, Li-Yuan Bai, Makoto Ueno, Antoine Italiano, Kyriakos Papadopoulos, David Spigel, Sani H. Kizilbash, Rasha Cosman, Joon Oh Park, Li-Tzong Chen, Tomoya Yokota, Anita A. Turk, Chih-Yi Liao, Rachna Shroff, Anthony El-Khoueiry, Taroh Satoh, Antoine Hollebecque, Mitesh J. Borad, Nilofer Azad, Kurt A. Jaeckle, Herbert H. Loong, Jorge Adeva, Wei Peng Yong, Junjie Zhao, Hui Liu, Anna M. Szpurka, Ivelina Gueorguieva, Kamnesh R. Pradhan, Xiaojian Xu, James J. Harding
Article
Urology & Nephrology
David Pasquier, Philippe Nickers, Didier Peiffert, Philippe Maingon, Pascal Pommier, Thomas Lacornerie, Emmanuelle Tresch, Mael Barthoulot, Eric Lartigau
Summary: This study assessed the late tolerance and relapse-free survival in patients with intermediate-risk prostate cancer undergoing hypofractionated stereotactic boost therapy after external beam radiotherapy. The results showed low GU and GI toxicities and good survival rates, suggesting that this treatment option is safe for use in future trials.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Article
Oncology
Tan Mai Nguyen, Chloe Bertolus, Paul Giraud, Anita Burgun, Pierre Saintigny, Jean-Emmanuel Bibault, Jean-Philippe Foy
Summary: This study aimed to distinguish hot and cold head and neck squamous cell carcinomas (HNSCCs) using imaging data from computed tomography (CT) scans. A computational model was established to determine the hot/cold status non-invasively, which could help identify patients with HNSCC who may benefit from immunotherapy.