Article
Biochemistry & Molecular Biology
Lian Liu, Quan Cao, Wenwei Gao, Bing-yu Li, Cheng Zeng, Zhongyuan Xia, Bo Zhao
Summary: Melatonin treatment can protect against CIR-induced brain damage in diabetic mice, possibly through enhancing autophagy mediated by the SIRT1-BMAL1 pathway.
Article
Plant Sciences
Nutda Sutthammikorn, Volaluck Supajatura, Hainan Yue, Miho Takahashi, Sunee Chansakaow, Nobuhiro Nakano, Pu Song, Takasuke Ogawa, Shigaku Ikeda, Ko Okumura, Hideoki Ogawa, Francois Niyonsaba
Summary: Gynura procumbens may have therapeutic effects on nonhealing diabetic wounds, promoting wound healing by accelerating the process and activating cells involved in the healing process. This suggests that G. procumbens could be an effective alternative therapeutic option for nonhealing diabetic wounds.
Article
Medicine, Research & Experimental
Ling Gao, Fan Qiu, Hao Cao, Hao Li, Gonghua Dai, Teng Ma, Yanshan Gong, Wei Luo, Dongling Zhu, Zhixuan Qiu, Ping Zhu, Shuguang Chu, Huangtian Yang, Zhongmin Liu
Summary: This study found that altering the levels of a specific miRNA (miR-125a-5p) in the heart can replicate the cardioprotective effects of mesenchymal stem cells and their secreted exosomes, increasing cardiac function and limiting adverse remodeling. In addition, miR-125a-5p treatment can promote angiogenesis, inhibit fibroblast proliferation and activation, and change the function of macrophages and endothelial cells through regulation of specific genes.
Article
Cardiac & Cardiovascular Systems
Wahiba Dhahri, Sylvie Dussault, Nozha Raguema, Michel Desjarlais, Alain Rivard
Summary: This study found that Riociguat, an sGC stimulator, promotes angiogenesis and improves neovascularization after ischemia. The mechanism involves the activation of the p44/p42 MAP kinase pathway and an increase in the number and functions of PACs. This discovery could potentially serve as a new therapeutic strategy for reducing tissue ischemia in patients with severe atherosclerotic diseases.
Article
Chemistry, Multidisciplinary
Lai-liu Luo, Jing-xuan Han, Shou-rong Wu, Vivi Kasim
Summary: This study suggests that SGLT2 inhibitor sotagliflozin may serve as a potential therapeutic angiogenesis agent for diabetic hindlimb ischemia (HLI). The results demonstrate that sotagliflozin can reverse the detrimental effects of high glucose and hypoxia on skeletal muscle cells, increase the expression and secretion of angiogenic factors, enhance the migration and proliferation capabilities of vascular endothelial and smooth muscle cells, and promote the formation of functional blood vessels. In vivo experiments show that intramuscular injection of sotagliflozin effectively restores blood perfusion in diabetic HLI mice.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Food Science & Technology
Xiaoying Chen, Zhifei Zhang, Huiming Niu, Xinmiao Tian, Huibin Tian, Weiwei Yao, Huanshan He, Huaiping Shi, Cong Li, Jun Luo
Summary: The goat milk diet improves glucose homeostasis and pancreatic conditions in type 2 diabetes mellitus mice, with positive effects on blood metabolite profiles and activation of pancreatic AKT pathway. The effects of digested goat milk on cell viability and apoptosis in Min6 cells are observed and may serve as potential biomarkers for diabetes treatment.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Cell Biology
Rosario Amato, Alberto Melecchi, Laura Pucci, Alessio Canovai, Silvia Marracci, Maurizio Cammalleri, Massimo Dal Monte, Carla Caddeo, Giovanni Casini
Summary: Encapsulating Lisosan G (LG) in liposomes can enhance its protective effects against diabetic retinopathy-induced damage to the retina.
Article
Endocrinology & Metabolism
Evelyn Lara, Nathaly Rivera, Alejandro Gonzalez-Bernal, Daniela Rojas, Daniela Lopez-Espindola, Andres Rodriguez, Carlos Escudero
Summary: This study evaluated brain microvascular perfusion and microvascular reactivity in offspring born to mice with preeclampsia-like syndrome. It found that the offspring exhibited impaired brain perfusion and microvascular reactivity, particularly in female mice, associated with differential expression of angiogenic proteins in the brain tissue.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Xiaowei Fei, Ya-nan Dou, Weihao Lv, Boyun Ding, Jialiang Wei, Xiuquan Wu, Xin He, Zhou Fei, Fei Fei
Summary: This study found that TLR4 knockout mice had improved learning and memory abilities during the aging stage, along with changes in synaptic spines, blood-brain barrier integrity, memory regulatory proteins, blood flow, and inflammatory factors. These findings suggest an important role of TLR4 in neurobehavioral function.
Article
Pharmacology & Pharmacy
Zhenlong Chen, Jacob M. Haus, Luisa A. DiPietro, Timothy J. Koh, Richard D. Minshall
Summary: The excessive level of chemokine CCL28, through its receptor CCR10, impairs wound healing in patients and mice with type 2 diabetes mellitus (T2DM). However, the mechanisms by which T2DM and inflammation negatively impact skin wound healing remains poorly understood. In this study, neutralizing anti-CCL28 antibody was shown to accelerate wound healing and restore angiogenesis, suggesting its potential as a therapeutic strategy for chronic non-healing diabetic skin wounds.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Tetsuhiro Harimoto, Jaeseung Hahn, Yu-Yu Chen, Jongwon Im, Joanna Zhang, Nicholas Hou, Fangda Li, Courtney Coker, Kelsey Gray, Nicole Harr, Sreyan Chowdhury, Kelly Pu, Clare Nimura, Nicholas Arpaia, Kam W. Leong, Tal Danino
Summary: This study developed a genetically encoded microbial encapsulation system with tunable and dynamic expression of surface capsular polysaccharides to enhance systemic delivery. The system allowed bacteria to temporarily evade immune attack and be effectively cleared in vivo. The results showed that this strategy increased the maximum tolerated dose of bacteria and improved anti-tumor efficacy.
Article
Endocrinology & Metabolism
Kfir Molakandov, Denise A. Berti, Avital Beck, Ofer Elhanani, Michael D. Walker, Yoav Soen, Karina Yavriyants, Michal Zimerman, Ella Volman, Itzik Toledo, Anna Erukhimovich, Alon M. Levy, Arik Hasson, Joseph Itskovitz-Eldor, Judith Chebath, Michel Revel
Summary: The study investigated a method to refine the composition of islet-like clusters (ILC) differentiated from human pluripotent stem cells by negative selection to remove CD26 expressing cells and positive selection for CD49A expressing cells, aiming to improve the effectiveness of cell therapy for diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Robert Arnar Karlsson, Olof Birna Olafsdottir, Vedis Helgadottir, Soumaya Belhadj, Thorunn Scheving Eliasdottir, Einar Stefansson, Sveinn Hakon Hardarson
Summary: Automated measurements of retinal oximetry values are more repeatable compared to measurements where vessels are selected manually, with higher ICC values for the automated version than the semiautomatic version.
Article
Biochemistry & Molecular Biology
Chin-Sung Kuo, Chi-Yu Chen, Hsin-Lei Huang, Hsiao-Ya Tsai, Ruey-Hsing Chou, Jih-Hua Wei, Po-Hsun Huang, Shing-Jong Lin
Summary: This study demonstrates that melatonin pretreatment can restore endothelial progenitor cell (EPC) function impairment and improve circulation recovery in a diabetic critical limb ischemia mouse model. Melatonin reverses the harmful effects of hyperglycemia on EPC through AMPK-related mechanisms and increases eNOS phosphorylation and heme oxygenase-1 expression. Melatonin treatment augments EPC function and neovascularization in response to ischemia in diabetic mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wenjing Niu, Haibo Wang, Bo Wang, Xueying Mao, Min Du
Summary: Obesity inhibits muscle regeneration, but resveratrol may enhance mitochondrial biogenesis and muscle regeneration by activating AMPK.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Martin Reindl, Sebastian Johannes Reinstadler, Hans-Josef Feistritzer, Lukas Mueller, Constantin Koch, Agnes Mayr, Markus Theurl, Rudolf Kirchmair, Gert Klug, Bernhard Metzler
Article
Biochemistry & Molecular Biology
Markus Theurl, Daniela Lener, Karin Albrecht-Schgoer, Arno Beer, Wilfried Schgoer, Yu Liu, Ursula Stanzl, Reiner Fischer-Colbrie, Rudolf Kirchmair
Article
Cardiac & Cardiovascular Systems
Martin Reindl, Sebastian Johannes Reinstadler, Christina Tiller, Markus Kofler, Markus Theurl, Nora Klier, Katherina Fleischmann, Agnes Mayr, Benjamin Henninger, Gert Klug, Bernhard Metzler
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Can Gollmann-Tepekoeylue, Daniela Lobenwein, Markus Theurl, Uwe Primessnig, Daniela Lener, Elke Kirchmair, Wolfgang Mathes, Michael Graber, Leo Poelzl, Angela An, Katarzyna Koziel, Elisabeth Pechriggl, Jakob Voelkl, Patrick Paulus, Wolfgang Schaden, Michael Grimm, Rudolf Kirchmair, Johannes Holfeld
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2018)
Article
Immunology
Sebastian Peer, Giuseppe Cappellano, Natascha Hermann-Kleiter, Karin Albrecht-Schgoer, Reinhard Hinterleitner, Gottfried Baier, Thomas Gruber
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Medicine, General & Internal
Maria Noflatscher, Michael Schreinlechner, Philip Sommer, Julia Kerschbaum, Katharina Berggren, Markus Theurl, Rudolf Kirchmair, Peter Marschang
JOURNAL OF CLINICAL MEDICINE
(2019)
Letter
Cardiac & Cardiovascular Systems
Michael Schreinlechner, Maria Noflatscher, Christian Kremser, Ruth Steiger, Julia Groemer, Markus Theurl, Rudolf Kirchmair, Agnes Mayr, Peter Marschang
JACC-CARDIOVASCULAR IMAGING
(2019)
Article
Cardiac & Cardiovascular Systems
Michael Schreinlechner, Maria Noflatscher, Sebastian Johannes Reinstadler, Philip Sommer, Daniela Lener, Elisabeth Reiser, Markus Theurl, Rudolf Kirchmair, Axel Bauer, Peter Marschang
Article
Medicine, General & Internal
Michael Schreinlechner, Maria Noflatscher, Daniela Lener, Axel Bauer, Rudolf Kirchmair, Peter Marschang, Markus Theurl
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Nutrition & Dietetics
Maria Noflatscher, Michael Schreinlechner, Philip Sommer, Philipp Deutinger, Markus Theurl, Rudolf Kirchmair, Axel Bauer, Peter Marschang
Review
Immunology
Karin Albrecht-Schgoer, Peter Lackner, Erich Schmutzhard, Gottfried Baier
Summary: This review focuses on the current clinical and immunological aspects of cerebral malaria induced by Plasmodium falciparum infection. It emphasizes the understanding of the underlying molecular mechanisms, while acknowledging unresolved issues in the inflammatory responses. The review also highlights the limitations in preventative diagnosis and treatment, and explores the recent research findings on immune mechanisms, specifically the role of CD8+ T cells in the central nervous system. Overall, it provides insights into potential immune-modulating adjunctive therapies for symptomatic cerebral participation of Plasmodium falciparum infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Noflatscher, Monika Hunjadi, Michael Schreinlechner, Philip Sommer, Daniela Lener, Markus Theurl, Rudolf Kirchmair, Axel Bauer, Andreas Ritsch, Peter Marschang
Summary: In this study, a negative correlation was found between high peripheral plaque volume and cholesterol efflux capacity (CEC). This result supports the role of CEC in the pathophysiology of atherosclerosis.
Article
Cell Biology
E. A. Wallnoefer, G. C. Thurner, C. Kremser, H. Talasz, M. M. Stollenwerk, A. Helbok, N. Klammsteiner, K. Albrecht-Schgoer, H. Dietrich, W. Jaschke, P. Debbage
Summary: This study explored the pharmacokinetics of nanoparticles based on albumin-DTPA-gadolinium chelates and found that gadolinium was stored long-term in the liver, kidneys, and spleen, posing a significant toxicity risk due to intracellular processing.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alex Pizzini, Thomas Sonnweber, Renate Frank, Markus Theurl, Guenter Weiss, Ivan Tancevski, Judith Loeffler-Ragg
PULMONARY CIRCULATION
(2020)