Cysteine Methylation Controls Radical Generation in the Cfr Radical AdoMet rRNA Methyltransferase

Transferable Plasmid-Mediated Resistance to Linezolid Due tocfrin a Human Clinical Isolate of Enterococcus faecalis

(2012) Lorena Diaz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hydrogen Transfer in SAM-Mediated Enzymatic Radical Reactions

(2012) Johnny Hioe et al.   CHEMISTRY-A EUROPEAN JOURNAL

Detection of the staphylococcal multiresistance gene cfr in Escherichia coli of domestic-animal origin

(2012) Y. Wang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme

(2012) Alhosna Benjdia et al.   NUCLEIC ACIDS RESEARCH

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS

(2011) Qi Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

First Report of the Multidrug Resistance Genecfrin Enterococcus faecalis of Animal Origin

(2011) Yang Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural Insights into Radical Generation by the Radical SAM Superfamily

(2011) Jessica L. Vey et al.   CHEMICAL REVIEWS

Characterization of NocL Involved in Thiopeptide Nocathiacin I Biosynthesis

(2011) Qi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cfr and RlmN Contain a Single [4Fe-4S] Cluster, which Directs Two Distinct Reactivities forS-Adenosylmethionine: Methyl Transfer by SN2 Displacement and Radical Generation

(2011) Tyler L. Grove et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical S-adenosylmethionine enzymes: Mechanism, control and function

(2011) Martin R. Challand et al.   NATURAL PRODUCT REPORTS

Radical-mediated enzymatic carbon chain fragmentation-recombination

(2011) Qi Zhang et al.   Nature Chemical Biology

RNA methylation by Radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

(2011) F. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Radically Different Mechanism for S-Adenosylmethionine-Dependent Methyltransferases

(2011) T. L. Grove et al.   SCIENCE

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

(2011) A. K. Boal et al.   SCIENCE

[FeFe]-Hydrogenase Cyanide Ligands Derived From S-Adenosylmethionine-Dependent Cleavage of Tyrosine

(2010) Rebecca C. Driesener et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biotin Synthase Exhibits Burst Kinetics and Multiple Turnovers in the Absence of Inhibition by Products and Product-Related Biomolecules

(2010) Christine E. Farrar et al.   BIOCHEMISTRY

Radicals from S-adenosylmethionine and their application to biosynthesis

(2010) Peter L Roach   CURRENT OPINION IN CHEMICAL BIOLOGY

S-Adenosylmethionine-dependent radical-based modification of biological macromolecules

(2010) Mohamed Atta et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Anaerobic sulfatase-maturating enzyme - A mechanistic link with glycyl radical-activating enzymes?

(2010) Alhosna Benjdia et al.   FEBS Journal

The antiviral protein viperin is a radical SAM enzyme

(2010) Kaitlin S. Duschene et al.   FEBS LETTERS

[FeFe]-Hydrogenase Maturation: HydG-Catalyzed Synthesis of Carbon Monoxide

(2010) Eric M. Shepard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RlmN and Cfr are Radical SAM Enzymes Involved in Methylation of Ribosomal RNA

(2010) Feng Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-level expression and reconstitution of active Cfr, a radical-SAM rRNA methyltransferase that confers resistance to ribosome-acting antibiotics

(2010) Michael P.S. Booth et al.   PROTEIN EXPRESSION AND PURIFICATION

Catalytic Activity of the Anaerobic Tyrosine Lyase Required for Thiamine Biosynthesis in Escherichia coli

(2009) Martin R. Challand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Iron-Sulfur Cluster Is Essential for the Binding of Broken DNA by AddAB-type Helicase-Nucleases

(2009) Joseph T. P. Yeeles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

(2009) A. M. B. Giessing et al.   RNA

X-ray Structure of the [FeFe]-Hydrogenase Maturase HydE fromThermotoga maritima

(2008) Yvain Nicolet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linezolid (ZYVOX), the First Member of a Completely New Class of Antibacterial Agents for Treatment of Serious Gram-Positive Infections

(2008) Steven J. Brickner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme

(2008) J. L. Vey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA