Article
Immunology
Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Summary: Alzheimer's disease is characterized by pathological deposition of misfolded self-protein amyloid beta, leading to neuroinflammation. Effector T cells induced by self-antigens accelerate disease progression, suggesting a potential therapeutic target in controlling AD pathology.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Pawan K. Gupta, Jennifer B. Allocco, Jane M. Fraipont, Michelle L. McKeague, Peter Wang, Michael S. Andrade, Christine McIntosh, Luqiu Chen, Ying Wang, Yan Li, Jorge Andrade, Jose R. Conejo-Garcia, Anita S. Chong, Maria-Luisa Alegre
Summary: This study investigates the susceptibility of Tconvs to Treg suppression during tolerance induction in transplantation. The findings suggest that transplantation tolerance is associated with an increased sensitivity of alloreactive Tconvs to Treg suppression, which is regulated by the expression of the transcription factor Satb1. Targeting Satb1 could potentially be a strategy to improve transplant outcomes by modulating Treg-sparing immunosuppressive therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Benedetta De Ponte Conti, Annarita Miluzio, Fabio Grassi, Sergio Abrignani, Stefano Biffo, Sara Ricciardi
Summary: The systematic analysis on translation rate of tumor-infiltrating lymphocytes (TILs) in humans and mice shows that high translation levels are associated with mTORC1 activation and low levels are correlated with hypoxia. CD8 translating cells exhibit a cytotoxic phenotype, while CD4 translating cells are mainly regulatory T cells with immunosuppressive functions.
Article
Biology
Marie Strickland, Salanne Lee, Shi Yong Neo, Akhila Balachander, Ivy Low, Seri Mustafah, Wah Ing Goh, Graham D. D. Wright, Anis Larbi, Sylvia L. F. Pender
Summary: The study focuses on investigating the impact of mitochondrial dysfunction on immune responses to infection and vaccination in the elderly population. Specifically, it examines the metabolic responses and mitochondrial dynamics of CD4+ TEMRA cells and other CD4+ memory T cell subtypes. The results show that CD4+ TEMRA cells exhibit altered mitochondrial dynamics, increased glucose uptake, and higher mitochondrial mass, which may contribute to impaired responses to infection and vaccination.
Article
Immunology
Sarah L. Bevington, Remi Fiancette, Dominika W. Gajdasik, Peter Keane, Jake K. Soley, Claire M. Willis, Daniel J. L. Coleman, David R. Withers, Peter N. Cockerill
Summary: Research reveals that T cell immunological memory is established within 7 days post-infection, with epigenetic programs playing a crucial role in Th differentiation and memory T cell formation. Memory T cell-specific regulatory elements contribute to enhanced inducible responses during secondary antigen exposures.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Laura A. Shaw, Tianda Z. Deng, Kyla D. Omilusik, Kennidy K. Takehara, Quynh P. Nguyen, Ananda W. Goldrath
Summary: CD4(+) T cells are important in vaccine development, but the existence of multiple helper subsets complicates the identification of memory precursor cells. Recent research has found that the expression of Id3 can identify a subset of CD4(+) T cells with memory potential, which exhibit significant re-expansion in response to secondary infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Fisheries
Belen Alvarez, Concepcion Revilla, Sara Moreno, Angeles Jimenez-Marin, Elena Ramos, Paloma Martinez de la Riva, Teresa Poderoso, Juan J. Garrido, Angel Ezquerra, Javier Dominguez
Summary: This report describes a new monoclonal antibody, 4H5CR4, against porcine CD9, which together with other antibodies can distinguish at least five CD4(+) T cell subsets. The analysis of CD45RA, CD27, CD29, CD95, CCR7, and SLA-DR markers on these subsets reveals a progressive model of CD4(+) T cell development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Review
Immunology
Michael L. Dixon, Jonathan D. Leavenworth, Jianmei W. Leavenworth
Summary: Regulatory T-cells, particularly effector Tregs (eTregs), play a crucial role in maintaining self-tolerance and tissue homeostasis, with potential implications in tumor development. Understanding the mechanisms that modulate the stability and suppressive function of tumoral Tregs, such as eTregs and T-FR cells, can lead to the development of more effective cancer immunotherapies that target the tumor microenvironment while minimizing systemic side effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Shi-Peng Li, Jin-Ming Zhang, Xiao-Jie Chen, Guang-Peng Zhou, Jie Sun, Bin Cui, Liu-Xin Zhou, Hai-Ming Zhang, Wei-Tao Que, Li-Ying Sun, Zhi-Jun Zhu
Summary: DPT cells are increased in liver transplant patients, especially in rejection cases. These cells show contiguity with Treg cells and their exhaustion is enhanced by increased PD-1 expression. These findings suggest that DPT cells may play a role in immune tolerance and could be targeted for preventing liver transplant rejection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Elizabeth Robins, Ming Zheng, Qingshan Ni, Siqi Liu, Chen Liang, Baojun Zhang, Jian Guo, Yuan Zhuang, You-Wen He, Ping Zhu, Ying Wan, Qi-Jing Li
Summary: Recent research has revealed that CD4(+) and CD8(+) T cells in adaptive immunity can exhibit significant lineage plasticity, even undergoing fundamental lineage reprogramming. This shift in functional potential may suggest a new direction for HIV vaccine design.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
David Y. Oh, Lawrence Fong
Summary: Cytotoxic CD4(+) T cells play important roles in both cancer and non-cancer environments, where they can directly kill cancer cells. They are also found in situations like infection and autoimmunity. The cytolytic mechanisms of cytotoxic CD4(+) T cells vary across different disease states.
Article
Multidisciplinary Sciences
Fabienne Mazerolles, Frederic Rieux-Laucat
Summary: The expression of co-signalling receptors on T cells plays a crucial role in regulating T cell responses, and an imbalance between activating and inhibitory signals may lead to autoimmunity. Research showed that activated TEFFs and TREGs express different co-signalling receptors, and the expression of PD-L1 on activated TEFFs is correlated with their proliferation.
Article
Geriatrics & Gerontology
Stephanie M. Dillon, Tezha A. Thompson, Allison J. Christians, Martin D. McCarter, Cara C. Wilson
Summary: The study found that older individuals had higher frequencies of colonic CD4 T cells, but lower expression of inhibitory markers such as CTLA-4 and PD-1. However, similar changes were not observed in CD4 T cells from peripheral blood in the same age group.
Article
Immunology
Gamze Gulden, Berranur Sert, Tarik Teymur, Yasin Ay, Nulifer Neslihan Tiryaki, Abhinava K. Mishra, Ercument Ovali, Nevzat Tarhan, Cihan Tastan
Summary: The development of genetic modification techniques has opened up a new era in cancer treatment by increasing the effectiveness and stability of CAR-T cell therapy. This study explores the use of Phytohemagglutinin (PHA) to increase the population of T cell memory phenotype in CAR-T cells, leading to long-term and efficient production of CAR-T cells.
Article
Biochemistry & Molecular Biology
Xueting Wang, Juncai Ma, Xuejiao Jin, Ning Yue, Peng Gao, Keith Ka Ki Mai, Xian-Bing Wang, Dawei Li, Byung-Ho Kang, Yongliang Zhang
Summary: This study utilized 3D visualization techniques to examine the effects of different viruses on vacuole structure, revealing ultrastructural changes during viral infection and highlighting the role of viral replication proteins in inducing vacuolar membrane remodeling. These findings provide insights into vacuole biogenesis and assembly of plant (+) RNA virus replication complexes.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zongyu Gao, Heng Pu, Jingyuan Liu, Xiaoling Wang, Chenchen Zhong, Ning Yue, Ziding Zhang, Xian-Bing Wang, Chenggui Han, Jialin Yu, Dawei Li, Yongliang Zhang
Summary: The study investigates systemic infections of Tobacco necrosis virus-A(C) in Nicotiana benthamiana and Glycine max through alanine-scanning mutagenesis of the viral coat protein. Key amino acid residues were identified as mediators of varying degrees of systemic infections in different hosts. The results expand understanding of host-dependent long-distance movement of icosahedral viruses in plants.
MOLECULAR PLANT-MICROBE INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Xueting Wang, Zhihao Jiang, Ning Yue, Xuejiao Jin, Xuan Zhang, Zhaolei Li, Yongliang Zhang, Xian-Bing Wang, Chenggui Han, Jialin Yu, Dawei Li
Summary: The study reveals that BSMV infection induces chloroplast oxidative stress, and the gamma b protein interacts with NTRC to affect viral replication in plants. Overexpression of NbNTRC inhibits BSMV replication, while disruption of NbNTRC expression leads to increased viral accumulation and severity of infection.
Correction
Biochemistry & Molecular Biology
Yexian Yuan, Pingwen Xu, Qingyan Jiang, Xingcai Cai, Tao Wang, Wentong Peng, Jiajie Sun, Canjun Zhu, Cha Zhang, Dong Yue, Zhihui He, Jinping Yang, Yuxian Zeng, Man Du, Fenglin Zhang, Lucas Ibrahimi, Sarah Schaul, Yuwei Jiang, Jiqiu Wang, Jia Sun, Qiaoping Wang, Liming Liu, Songbo Wang, Lina Wang, Xiaotong Zhu, Ping Gao, Qianyun Xi, Cong Yin, Fan Li, Guli Xu, Yongliang Zhang, Gang Shu
Correction
Biochemistry & Molecular Biology
Tao Wang, Ya-Qiong Xu, Ye-Xian Yuan, Ping-Wen Xu, Cha Zhang, Fan Li, Li-Na Wang, Cong Yin, Lin Zhang, Xing-Cai Cai, Can-Jun Zhu, Jing-Ren Xu, Bing-Qing Liang, Sarah Schaul, Pei-Pei Xie, Dong Yue, Zheng-Rui Liao, Lu-Lu Yu, Lv Luo, Gan Zhou, Jin-Ping Yang, Zhi-hui He, Man Du, Yu-Ping Zhou, Bai-Chuan Deng, Song-Bo Wang, Ping Gao, Xiao-Tong Zhu, Qian-Yun Xi, Yong-Liang Zhang, Gang Shu, Qing-Yan Jiang
Article
Biochemistry & Molecular Biology
Tingdong Li, Jiacheng Hu, Yu Sun, Boshu Li, Dingliang Zhang, Wenli Li, Jinxing Liu, Dawei Li, Caixia Gao, Yongliang Zhang, Yanpeng Wang
Summary: This study developed a Barley stripe mosaic virus-based sgRNA delivery vector for heritable genome editing in Cas9-transgenic wheat plants, achieving mutated progenies with frequencies ranging from 12.9% to 100%. The researchers also successfully performed multiplex mutagenesis in progeny using a pool of BSMV-sg vectors, as well as devised a virus-induced transgene-free editing procedure to generate Cas9-free wheat mutants.
Article
Plant Sciences
Zhaolei Li, Xinxin Yang, Wenli Li, Zhiyan Wen, Jiangning Duan, Zhihao Jiang, Dingliang Zhang, Xialin Xie, Xueting Wang, Fangfang Li, Dawei Li, Yongliang Zhang
Summary: In this study, we found that SAMDC3 is involved in defense against BSMV infection by regulating the abundance of the γb protein. This finding contributes to our understanding of how a plant host deploys the ubiquitin-proteasome system to mount defenses against viral infections.
Article
Multidisciplinary Sciences
Zongyu Gao, Dingliang Zhang, Xiaoling Wang, Xin Zhang, Zhiyan Wen, Qianshen Zhang, Dawei Li, Savithramma P. Dinesh-Kumar, Yongliang Zhang
Summary: The study reveals that beet black scorch virus activates MAPK signaling in plants and the viral coat protein counteracts MAPK-mediated defense. This finding highlights the importance of MAPK cascades in plant defense against viral infections.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ning Yue, Zhihao Jiang, Xuan Zhang, Zhenggang Li, Xueting Wang, Zhiyan Wen, Zongyu Gao, Qinglin Pi, Yongliang Zhang, Xian-Bing Wang, Chenggui Han, Jialin Yu, Dawei Li
Summary: Viral replication and movement are closely related, but the molecular mechanisms controlling the transition between replication and movement are mostly unknown. This study discovered that palmitoylation of the BSMV γb protein in tobacco regulates viral replication and movement.
Article
Plant Sciences
Qiuhong Wu, Yu Cui, Xuejiao Jin, Guoxin Wang, Lijie Yan, Chenchen Zhong, Meihua Yu, Wenli Li, Yong Wang, Ling Wang, Hao Wang, Chen Dang, Xinyu Zhang, Yongxing Chen, Panpan Zhang, Xiaofei Zhao, Jiajie Wu, Daolin Fu, Lanqin Xia, Eviatar Nevo, John Vogel, Naxin Huo, Dawei Li, Yong Q. Gu, Andrew O. Jackson, Yongliang Zhang, Zhiyong Liu
Summary: In this study, researchers isolated a resistance gene called barley stripe resistance 1 (BSR1) from the Brachypodium distachyon Bd3-1 inbred line using map-based cloning. They found that BSR1, a member of the nucleotide binding, leucine-rich repeat immune receptor (NLR) protein family, confers resistance to Barley stripe mosaic virus (BSMV) in monocots. Protein domain swaps revealed that the intact leucine-rich repeat (LRR) domain and the C-terminus of BSR1 are essential for resistance. BSR1 interacts with BSMV ND18 TGB1 protein in plant and exhibits temperature-sensitive antiviral resistance.
Article
Multidisciplinary Sciences
Dingliang Zhang, Zongyu Gao, He Zhang, Yizhou Yang, Xinxin Yang, Xiaofei Zhao, Hailong Guo, Ugrappa Nagalakshmi, Dawei Li, Savithramma P. Dinesh-Kumar, Yongliang Zhang
Summary: This article investigates a novel MAPK-AL7 module that promotes NLR-mediated immunity by inhibiting the transcription of ROS scavenging genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Qianshen Zhang, Zhiyan Wen, Xin Zhang, Jiajie She, Xiaoling Wang, Zongyu Gao, Ruiqi Wang, Xiaofei Zhao, Zhen Su, Zhen Li, Dawei Li, Xiaofeng Wang, Yongliang Zhang
Summary: The study employed TurboID-based proximity labeling to investigate the replication of a plant virus and identified RETICULON-LIKE PROTEIN B2 as a proviral factor in viral replication complex formation.
Article
Plant Sciences
Zhihao Jiang, Xuejiao Jin, Meng Yang, Qinglin Pi, Qing Cao, Zhenggang Li, Yongliang Zhang, Xian-Bing Wang, Chenggui Han, Jialin Yu, Dawei Li
Summary: Barley stripe mosaic virus gamma b protein impairs the reductase activity of thioredoxin h-type 1 and reduces the expression of downstream salicylic acid-related genes, facilitating the movement of the virus between cells. Additionally, the gamma b protein interacts with and targets thioredoxin h-type 1 to optimize viral cell-to-cell movement. The study also highlights the broad-spectrum antibiotic role of the salicylic acid signaling pathway.
Review
Biochemistry & Molecular Biology
Xinxin Yang, Zhiyan Wen, Dingliang Zhang, Zhen Li, Dawei Li, Ugrappa Nagalakshmi, Savithramma P. Dinesh-Kumar, Yongliang Zhang
Summary: This article summarizes recent advances in the use of proximity labeling (PL) in plant biology, including the development and comparison of different PL enzymes, and the application of PL in deciphering various molecular interactions in different organisms with a focus on plant systems.
PLANT COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Canjun Zhu, Zhiyue Xu, Yexian Yuan, Tao Wang, Chang Xu, Cong Yin, Peipei Xie, Pingwen Xu, Hui Ye, Nirali Patel, Sarah Schaul, Lina Wang, Xiaotong Zhu, Songbo Wang, Ping Gao, Qianyun Xi, Yongliang Zhang, Gang Shu, Qingyan Jiang
Summary: Heparin levels are positively associated with blood glucose, leading to impaired glucose homeostasis by inhibiting insulin binding and the PI3K/Akt signaling pathway activation in skeletal muscle. These effects are independent of its anticoagulant function.
ENDOCRINOLOGY DIABETES & METABOLISM
(2021)
