Binding, Conformational Transition and Dimerization of Amyloid-β Peptide on GM1-Containing Ternary Membrane: Insights from Molecular Dynamics Simulation

GM1 Cluster Mediates Formation of Toxic Aβ Fibrils by Providing Hydrophobic Environments

(2012) Saori Fukunaga et al.   BIOCHEMISTRY

Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation

(2012) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane

(2012) Hyunbum Jang et al.   Journal of Chemical Theory and Computation

Molecular Interactions of Alzheimer's Aβ Protofilaments with Lipid Membranes

(2012) Florentina Tofoleanu et al.   JOURNAL OF MOLECULAR BIOLOGY

Dimerization of the Full-Length Alzheimer Amyloid β-Peptide (Aβ42) in Explicit Aqueous Solution: A Molecular Dynamics Study

(2012) Xiaoxia Zhu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Multidimensional View of Amyloid Fibril Nucleation in Atomistic Detail

(2012) Fahimeh Baftizadeh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dimer Formation Enhances Structural Differences between Amyloid β-Protein (1–40) and (1–42): An Explicit-Solvent Molecular Dynamics Study

(2012) Bogdan Barz et al.   PLoS One

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Role of Water in Protein Aggregation and Amyloid Polymorphism

(2011) D. Thirumalai et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cholesterol Promotes the Interaction of Alzheimer β-Amyloid Monomer with Lipid Bilayer

(2011) Xiang Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Dynamics Simulations Reveal the Protective Role of Cholesterol in β-Amyloid Protein-Induced Membrane Disruptions in Neuronal Membrane Mimics

(2011) Liming Qiu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Amyloid β Peptides Aggregation in a Mixed Membrane Bilayer: A Molecular Dynamics Study

(2011) Li Na Zhao et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular Dynamics Simulations of the Interactions of Kinin Peptides with an Anionic POPG Bilayer

(2011) Moutusi Manna et al.   LANGMUIR

Cholesterol driven alteration of the conformation and dynamics of phospholamban in model membranes

(2011) Moutusi Manna et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Lipid composition influences the release of Alzheimer's amyloid β-peptide from membranes

(2011) Justin A. Lemkul et al.   PROTEIN SCIENCE

Designed Fluorescent Probes Reveal Interactions between Amyloid-β(1–40) Peptides and GM1 Gangliosides in Micelles and Lipid Vesicles

(2010) I. Mikhalyov et al.   BIOPHYSICAL JOURNAL

Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases

(2010) Jacques Fantini et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

NMR characterization of the interactions between lyso-GM1 aqueous micelles and amyloid β

(2010) Maho Yagi-Utsumi et al.   FEBS LETTERS

Disordered versus Fibril-like Amyloid β (25−35) Dimers in Water: Structure and Thermodynamics

(2010) Madeleine Kittner et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Interactions of Aβ25−35 β-Barrel-like Oligomers with Anionic Lipid Bilayer and Resulting Membrane Leakage: An All-Atom Molecular Dynamics Study

(2010) Zhongwen Chang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Transmembrane Structures for Alzheimer’s Aβ1−42Oligomers

(2010) Birgit Strodel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural diversity of dimers of the Alzheimer amyloid-β(25–35) peptide and polymorphism of the resulting fibrils

(2010) Guanghong Wei et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

How Cholesterol Constrains Glycolipid Conformation for Optimal Recognition of Alzheimer's β Amyloid Peptide (Aβ1-40)

(2010) Nouara Yahi et al.   PLoS One

Molecular mechanism of β-sheet self-organization at water-hydrophobic interfaces

(2010) Ana Nikolic et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Perturbation of membranes by the amyloid β-peptide - a molecular dynamics study

(2009) Justin A. Lemkul et al.   FEBS Journal

GM1 Ganglioside Embedded in a Hydrated DOPC Membrane: A Molecular Dynamics Simulation Study

(2009) Pál Jedlovszky et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure of the Amyloid-β (1−42) Monomer Absorbed To Model Phospholipid Bilayers: A Molecular Dynamics Study

(2009) Charles H. Davis et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Perturbations of Membrane Structure by Cholesterol and Cholesterol Derivatives Are Determined by Sterol Orientation

(2009) Brett N. Olsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cause and Effect of Melittin-Induced Pore Formation: A Computational Approach

(2009) Moutusi Manna et al.   LANGMUIR

Comparative Molecular Dynamics Study of Aβ Adsorption on the Self-Assembled Monolayers

(2009) Qiuming Wang et al.   LANGMUIR

Structures and Free-Energy Landscapes of the Wild Type and Mutants of the Aβ21–30 Peptide Are Determined by an Interplay between Intrapeptide Electrostatic and Hydrophobic Interactions

(2008) Bogdan Tarus et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Level Investigation of Organization in Ternary Lipid Bilayer: A Computational Approach

(2008) Sumita Mondal et al.   LANGMUIR

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

(2008) Wei-Feng Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA