Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases

Surface-induced phase separation of a sphingomyelin/cholesterol/ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates Aβ oligomerization

(2010) Yanli Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid–Alzheimer's disease relationships?

(2010) Andrew J. Beel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Aβ polymerization through interaction with membrane gangliosides

(2010) Katsumi Matsuzaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid raft disruption protects mature neurons against amyloid oligomer toxicity

(2010) Fiorella Malchiodi-Albedi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Notch ligand activity is modulated by glycosphingolipid membrane composition inDrosophila melanogaster

(2010) Sophie Hamel et al.   JOURNAL OF CELL BIOLOGY

Altered Ion Channel Formation by the Parkinson's-Disease-Linked E46K Mutant of α-Synuclein Is Corrected by GM3 but Not by GM1 Gangliosides

(2010) Eric Di Pasquale et al.   JOURNAL OF MOLECULAR BIOLOGY

Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early-Onset Form (Type I) and Demyelination in Late-Onset Form (Type II)

(2010) Lars Svennerholm et al.   JOURNAL OF NEUROCHEMISTRY

How Cholesterol Constrains Glycolipid Conformation for Optimal Recognition of Alzheimer's β Amyloid Peptide (Aβ1-40)

(2010) Nouara Yahi et al.   PLoS One

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Differential Phospholipid Binding of α-Synuclein Variants Implicated in Parkinson’s Disease Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   BIOCHEMISTRY

Sphingolipid/cholesterol regulation of neurotransmitter receptor conformation and function

(2009) Jacques Fantini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Unfoldomics of human diseases: linking protein intrinsic disorder with diseases

(2009) Vladimir N Uversky et al.   BMC GENOMICS

The first extracellular domain of the tumour stem cell marker CD133 contains an antigenic ganglioside-binding motif

(2009) Nadira Taïeb et al.   CANCER LETTERS

Surface chemistry of Alzheimer's disease: A Langmuir monolayer approach

(2009) Garima Thakur et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Lovastatin ameliorates α-synuclein accumulation and oxidation in transgenic mouse models of α-synucleinopathies

(2009) Andrew O. Koob et al.   EXPERIMENTAL NEUROLOGY

Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction

(2009) Elena Posse de Chaves et al.   FEBS LETTERS

The Mysterious Unfoldome: Structureless, Underappreciated, Yet Vital Part of Any Given Proteome

(2009) Vladimir N. Uversky   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cholesterol Regulates Assembly of Human Islet Amyloid Polypeptide on Model Membranes

(2009) Won-Jin Cho et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloidogenic Propensities and Conformational Properties of ProIAPP and IAPP in the Presence of Lipid Bilayer Membranes

(2009) Suman Jha et al.   JOURNAL OF MOLECULAR BIOLOGY

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

(2009) Ian J. Martins et al.   JOURNAL OF NEUROCHEMISTRY

Therapeutic potential of statins in Alzheimer's disease

(2009) Nagaendran Kandiah et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cholesterol involvement in the pathogenesis of neurodegenerative diseases

(2009) Jun-Ping Liu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Small molecule blockers of the Alzheimer A  calcium channel potently protect neurons from A  cytotoxicity

(2009) J. C. Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Driving force of binding of amyloid β-protein to lipid bilayers

(2008) Keisuke Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

α-Synuclein Conformation Affects Its Tyrosine-Dependent Oxidative Aggregation†

(2008) Rebecca A. S. Ruf et al.   BIOCHEMISTRY

The extracellular glycosphingolipid-binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand

(2008) K Chakrabandhu et al.   CELL DEATH AND DIFFERENTIATION

Up-and-down topological mode of amyloid β-peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters

(2008) Maho Utsumi et al.   GLYCOCONJUGATE JOURNAL

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

A fluorescent sphingolipid binding domain peptide probe interacts with sphingolipids and cholesterol-dependent raft domains

(2008) Sarita Hebbar et al.   JOURNAL OF LIPID RESEARCH

Fluorescence-topographic NSOM directly visualizes peak-valley polarities of GM1/GM3 rafts in cell membrane fluctuations

(2008) Yong Chen et al.   JOURNAL OF LIPID RESEARCH

The role of glycosphingolipid metabolism in the developing brain

(2008) Robert K. Yu et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Sphingolipids.Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease—a review,

(2008) Toshio Ariga et al.   JOURNAL OF LIPID RESEARCH

Formation of Toxic Aβ(1–40) Fibrils on GM1 Ganglioside-Containing Membranes Mimicking Lipid Rafts: Polymorphisms in Aβ(1–40) Fibrils

(2008) Takuma Okada et al.   JOURNAL OF MOLECULAR BIOLOGY

Evidence for an association of prion protein and sphingolipid-mediated signaling

(2008) Rdiger Schmalzbauer et al.   JOURNAL OF NEUROCHEMISTRY

Statins reduce neuronal α-synuclein aggregation in in vitro models of Parkinson’s disease

(2008) Pazit Bar-On et al.   JOURNAL OF NEUROCHEMISTRY

Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles

(2008) Elka R. Georgieva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cholesterol binding to amyloid-β fibrils: A TEM study

(2008) J. Robin Harris   MICRON

Signal transduction via unstructured protein conduits

(2008) A Keith Dunker et al.   Nature Chemical Biology

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

Total cholesterol and the risk of Parkinson disease

(2008) G. Hu et al.   NEUROLOGY

Controlled aggregation of adenine by sugars: physicochemical studies, molecular modelling simulations of sugar–aromatic CH–π stacking interactions, and biological significance

(2008) Marc Maresca et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using model membranes for the study of amyloid beta:lipid interactions and neurotoxicity

(2007) Mun'delanji Vestergaard et al.   BIOTECHNOLOGY AND BIOENGINEERING

α-Synuclein Selectively Binds to Anionic Phospholipids Embedded in Liquid-Disordered Domains

(2007) Martin Stöckl et al.   JOURNAL OF MOLECULAR BIOLOGY

ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain

(2007) Veera Venkata Ratnam Bandaru et al.   NEUROBIOLOGY OF AGING